Results 211 to 220 of about 649,858 (244)

Pediatric Human Olfactory Epithelium Mirrors Adult Structure and Function in a Human Olfactory Organoid Model

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Objective This study investigated the developmental differences in structure, gene expression, and function of human olfactory epithelium (OE) using pediatric and adult specimens and human olfactory organoids. Background Olfactory dysfunction (OD) is characterized by loss or alterations in the sense of smell and has an age‐related increase in ...
Randy Bach, Ankit Chauhan, Michael Xiang, Kang‐Hoon Kim, James N. Palmer, Nithin D. Adappa, Michael A. Kohanski, Noam A. Cohen, Hong Wang, Jennifer E. Douglas   +9 more
wiley   +1 more source

Gain‐of‐Function Engineering of the NifEN Scaffold Into a Self‐Assembling Nitrogenase

Angewandte Chemie, EarlyView.
From scaffold to enzyme: Systematic engineering of the cofactor maturation scaffold NifEN reconstructs the P→M electron relay along with cofactor coordination and proton gating at the S2B site, converting NifEN into a functional nitrogenase capable of ATP‐dependent N2 reduction both in vitro and in vivo.
Yimo Yang, Chi Chung Lee, Steve Ortiz, Markus W. Ribbe, Yilin Hu   +4 more
wiley   +2 more sources

Emerging roles of pterins as signaling molecules in bacteria. [PDF]

Biochem Soc Trans
Rucker P, Augusta L, Fuqua C, Allen KD.
europepmc   +1 more source

A mouse model of mechanical stress injury to the basal ganglia using thermosensitive PNIPAM hydrogel for intracerebral hemorrhage research

Animal Models and Experimental Medicine, EarlyView.
In this study, we established a novel mouse model of intracerebral hemorrhage (ICH) by stereotactically injecting thermosensitive PNIPAM hydrogel into the internal capsule to impose localized mechanical stress on the corticospinal tract, which provides a straightforward and reproducible tool for preclinical studies on focal mechanical stress–induced ...
Mingxi Li, Yujie Chen, Rongsu Huang, Min Xia, Chao Mi, Yuan Tian, Peiwen Guo, Taotao Jin, Shilei Hao, Hua Feng, Yujie Chen, Zhi Chen   +11 more
wiley   +1 more source

Application of a Lead Film-Modified CNT/SGC Electrode in the Voltammetric Analysis of Trace Concentrations of Mo(VI). [PDF]

Sensors (Basel)
Grabarczyk M, Cwikla-Bundyra W, Siewierska O.   +2 more
europepmc   +1 more source

Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment

Annals of Neurology, EarlyView.
Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring, Enya Abler, Jakub Vavra, Kristina Mayer, Johannes Dorst, Zeynep Elmas, Maximilian Wiesenfarth, Lars Richter, Susanne Petri, Martin Regensburger, Peter Reilich, Bogdan Bjelica, Rea Lumi, Patrick Süß, Hayrettin Tumani, Markus Otto, Jochen H. Weishaupt, Albert C. Ludolph, Patrick Oeckl   +18 more
wiley   +1 more source

The Dual Nature of Metals: Essential Nutrients and Environmental Contaminants. [PDF]

Int J Mol Sci
Rojas-Lemus M, López-Valdez N, González-Villalva A, Bizarro-Nevares P, Casarrubias-Tabarez B, Cervantes-Valencia ME, Ustarroz-Cano M, Rivera-Fernández N, Anacleto-Santos J, Chávez-Maya F, Milán-Chávez R, Morales-López S, Fortoul TI.   +12 more
europepmc   +1 more source

URMylation Signaling Pathway in Cancer: Molecular Mechanisms and Therapeutic Opportunities. [PDF]

Curr Issues Mol Biol
Wang J, Yan P, Jiang W, Chen L, Huang D, Hou T, Inuzuka H, Wei W.   +7 more
europepmc   +1 more source

The Manifestation of the Electrochemical Potential Gradient in the Kinetic Landscapes of Interfacial Electrochemistry

Angewandte Chemie International Edition, EarlyView.
The overpotential constitutes an electrochemical potential difference at the solid–liquid interface, which can manifest itself in different ways. In general, it can not only drive the reaction along the reaction coordinate, but also modulate chemical potentials in the extended environment that shape activation barriers, without necessarily being a ...
Sebastian Z. Oener, Caroline J. Aschendorf, Jody Druce, Francisco Sarabia, Carlos Gomez Rodellar, Mathieu Lizée, Alex Ricardo Silva Olaya, Soumyadip Mondal, Raquel Anastacio Amaral, Hađer Sinanović, Beatriz Roldan Cuenya   +10 more
wiley   +1 more source