Results 41 to 50 of about 5,659 (287)

The Effects of Surface Disturbances on the Leaching of Heavy Metals [PDF]

, 1987
The harmful effects of heavy metal contamination of surface waters impacted by gold mining activity are well documented. An examination was conducted on the effects of surface disturbances in Wade Creek on the concentrations of heavy metals in ...
Brown, Edward J., Dixson, David P.
core  

A new family of periplasmic-binding proteins that sense arsenic oxyanions [PDF]

, 2018
Arsenic contamination of drinking water affects more than 140 million people worldwide. While toxic to humans, inorganic forms of arsenic (arsenite and arsenate), can be used as energy sources for microbial respiration. AioX and its orthologues (ArxX and
AJ McCoy, C Baraquet, C Jourlin, CN Pace, D Malasarn, D Slyemi, DL Correll, DR Kashyap, E Afkar, E Lebrun, G Liu, GD Duyne Van, GH Scheepers, GL Anderson, GN Murshudov, H Edelhoch, I Alicea, J Andres, JM Santini, JM Santini, JM Santini, K Fukami-Kobayashi, K Kurashima-Ito, K Tamura, K Zargar, KH Johannesson, KU Kjeldsen, L Ferrières, LS Jenkins, M Meyer, MB Neiditch, MD Winn, P Emsley, RC Edgar, RS Oremland, S Duval, S Koechler, S Sardiwal, SF Altschul, T Krafft, TH Osborne, TP Warelow, WL DeLano, X Chen   +43 more
core   +5 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Experimental Study on Axial Compression Behavior of Molybdenum Tailings Concrete Column Confined by GFRP

Buildings
To promote the application of molybdenum tailings as the fine aggregate in concrete in construction engineering and verify the feasibility of fiber-reinforced polymer (FRP) material for strengthening molybdenum tailings concrete columns, this study takes
Jian Yuan, Xin Zhao, Lianmin Tian, Zhaolong Hou, Yunfeng Pan, Jun He   +5 more
doaj   +1 more source

Alaska mining and water quality [PDF]

, 1976
The Institute of Water Resources has sought financial assistance for some time in an attempt to initiate research relative to the impact of mining on water quality. Attempts were made as early as 1971 by Dr. Timothy Tilsworth and later by Dr.
Cook, Donald J., Tilsworth, Timothy, Zemansky, Gil M.   +2 more
core  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Differences between total amount of heavy metals and their occurrence form contents in the wastelands of a molybdenum mine area

International Journal of Coal Science & Technology, 2023
In a single sample plot, the total amount of heavy metals in the soil could not necessarily reflect the contents of their effective states. This must be considered when attempting to determine the degree of soil heavy-metal pollution in an area.
Ping Shi, Jing Huang, Zecan Wu, Aoshuang Chen, Guangxin Zhang   +4 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source