Results 41 to 50 of about 5,507 (297)

A new family of periplasmic-binding proteins that sense arsenic oxyanions [PDF]

, 2018
Arsenic contamination of drinking water affects more than 140 million people worldwide. While toxic to humans, inorganic forms of arsenic (arsenite and arsenate), can be used as energy sources for microbial respiration. AioX and its orthologues (ArxX and
AJ McCoy, C Baraquet, C Jourlin, CN Pace, D Malasarn, D Slyemi, DL Correll, DR Kashyap, E Afkar, E Lebrun, G Liu, GD Duyne Van, GH Scheepers, GL Anderson, GN Murshudov, H Edelhoch, I Alicea, J Andres, JM Santini, JM Santini, JM Santini, K Fukami-Kobayashi, K Kurashima-Ito, K Tamura, K Zargar, KH Johannesson, KU Kjeldsen, L Ferrières, LS Jenkins, M Meyer, MB Neiditch, MD Winn, P Emsley, RC Edgar, RS Oremland, S Duval, S Koechler, S Sardiwal, SF Altschul, T Krafft, TH Osborne, TP Warelow, WL DeLano, X Chen   +43 more
core   +5 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The Effects of Surface Disturbances on the Leaching of Heavy Metals [PDF]

, 1987
The harmful effects of heavy metal contamination of surface waters impacted by gold mining activity are well documented. An examination was conducted on the effects of surface disturbances in Wade Creek on the concentrations of heavy metals in ...
Brown, Edward J., Dixson, David P.
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Alaska mining and water quality [PDF]

, 1976
The Institute of Water Resources has sought financial assistance for some time in an attempt to initiate research relative to the impact of mining on water quality. Attempts were made as early as 1971 by Dr. Timothy Tilsworth and later by Dr.
Cook, Donald J., Tilsworth, Timothy, Zemansky, Gil M.   +2 more
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Experimental Study on Axial Compression Behavior of Molybdenum Tailings Concrete Column Confined by GFRP

Buildings
To promote the application of molybdenum tailings as the fine aggregate in concrete in construction engineering and verify the feasibility of fiber-reinforced polymer (FRP) material for strengthening molybdenum tailings concrete columns, this study takes
Jian Yuan, Xin Zhao, Lianmin Tian, Zhaolong Hou, Yunfeng Pan, Jun He   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Molybdenum supplementation of fat-tailed ewes diets in an arid region

Online Journal of Animal and Feed Research, 2022
The study aimed to establish the normal molybdenum requirements for open ewes of meat-and-fat breeds in arid climatic conditions. The study was carried out in the production conditions of the Buddha farm of the Republic of Kalmykia (Russia). The norm has been established based on a detailed study of the molybdenum content in organs and tissues and the ...
Djunaydi Sharamazanovich GAYIRBEGOV, Dmitry Borisovich MANDZHIEV, Tseden Badmaevich TYURBEEV   +2 more
openaire   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source