Results 71 to 80 of about 945 (112)

The history of the discovery of the molybdenum cofactor and novel aspects of its biosynthesis in bacteria

, 2011
The biosynthesis of the molybdenum cofactor in bacteria is described with a detailed analysis of each individual reaction leading to the formation of stable intermediates during the synthesis of molybdopterin from GTP.
Leimkühler, Silke (Prof. Dr.), Wuebbens, Margot M., Rajagopalan, K. V., Silke Leimkühler, Margot M. Wuebbens, K.V. Rajagopalan   +5 more
core   +1 more source

Nickel Complexes Based on Molybdopterin-like Dithiolenes: Catalysts for CO₂ Electroreduction

, 2018
Molecular metal (M)–dithiolene complexes are mimics of the active sites of metalloenzymes such as formate dehydrogenases and CO-dehydrogenases. Recently, the first M–dithiolene (M = Ni) complex behaving as a catalyst for carbon dioxide electroduction ...
Maria Gomez-Mingot (1498210), Marc Fontecave (847760), Thibault Fogeron (1498201), Pascal Retailleau (1445848), Yun Li (692280)   +4 more
core   +1 more source

Ten novel mutations in the molybdenum cofactor genes MOCS1 and MOCS2 and in vitro characterization of a MOCS2 mutation that abolishes the binding ability of molybdopterin synthase

, 2005
Molybdenum cofactor deficiency (MIM#252150) is a severe autosomal- recessive disorder with a devastating outcome. The cofactor is the product of a complex biosynthetic pathway involving four different genes (MOCS1, MOCS2, MOCS3 and GEPH).
Dorche, C., Charcosset, M., Latour, P., Kleppe, S., Scaglia, F., Leimkuhler, S., Schupp, P., Hahnewald, Rita, Reiss, Jochen, Szymczak, I.   +9 more
core   +2 more sources

Nickel Complexes Based on Molybdopterin-like Dithiolenes: Catalysts for CO 2 Electroreduction

, 2019
International audienceMolecular metal(M)-dithiolene complexes are mimics of the active sites of metalloenzymes such as formate dehydrogenases and CO-dehydrogenases.
Fogeron, Thibault, Li, Yun, Gomez-Mingot, Maria, Retailleau, Pascal, Fontecave, Marc   +4 more
core   +1 more source

A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase

, 2006
The small and large subunits of molybdopterin (MPT) synthase (MOCS2A and MOCS2B), are both encoded by the MOCS2 gene in overlapping and shifted open reading frames (ORFs), which is a highly unusual structure for eukaryotes.
Acquaviva-Bourdain, Cecile, Lenz, Ulrike, Leimkühler, Silke (Prof. Dr.), Leimkuehler, Silke, Hahnewald, Rita, Vilaseca, Antonia, Reiss, Jochen   +6 more
core   +1 more source

Promotion of oxygen atom transfer in Mo and W enzymes by bicyclic forms of the pterin cofactor

, 2005
Density functional theory calculations suggest that bicyclic structures of the "molybdopterin" in DMSO reductases may have an important catalytic role in oxygen atom transfer ...
Hillier, Ian H., Joule, John A., Garner, C. David, McNamara, Jonathan P.   +3 more
core   +1 more source

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic study of molybdopterin synthase from Thermus thermophilus HB8

, 2007
Thermus thermophilus is a Gram-negative aerobic thermophilic eubacterium which can grow at temperatures ranging from 323 to 355 K. In addition to their importance in thermostability or adaptation strategies for survival at high temperatures, the ...
Sekar, Kanagaraj, Jeyakanthan, Jeyaraman, Shiro, Yoshitsugu, Ebihara, Akio, Ranjani, Chellamuthu Vasuki, Agari, Kazuko, Ohmori, Miwa, Shinkai, Akeo, Yokoyama, Shigeyuki, Kanaujia, Shankar Prasad, Kuramitsu, Seiki, Kitamura, Yoshiaki, Baba, Seiki   +12 more
core  

A periplasmic aldehyde oxidoreductase represents the first molybdopterin cytosine dinucleotide cofactor containing molybdo-flavoenzyme from Escherichia coli

, 2009
Three DNA regions carrying genes encoding putative homologs of xanthine dehydrogenases were identified in Escherichia coli, named xdhABC, xdhD, and yagTSRQ. Here, we describe the purification and characterization of gene products of the yagTSRQ operon, a
Mittelstaedt, Gerd, Peter Hildebrandt, Meina Neumann, Lendzian, Friedhelm, Hildebrandt, Peter, Gerd Mittelstädt, Silke Leimkühler, Chantal Iobbi‐Nivol, Leimkühler, Silke (Prof. Dr.), Saggu, Miguel, Miguel Saggu, Iobbi-Nivol, Chantal, Friedhelm Lendzian, Neumann-Schaal, Meina   +13 more
core   +1 more source

The structure of a Molybdopterin Precursor

Journal of Biological Chemistry, 1989
J L Johnson, M M Wuebbens, K V Rajagopalan   +2 more
openaire   +1 more source

Molybdopterin biosynthesis: Trapping of intermediates for the MoaA-catalyzed reaction using 2′-deoxyGTP and 2′-chloroGTP as substrate analogues.

, 2014
MoaA is a radical S-adenosylmethionine (AdoMet) enzyme that catalyzes a complex rearrangement of guanosine-5\u27-triphosphate (GTP) in the first step of molybdopterin biosynthesis.
Mehta, Angad P., Xu, Hui, Abdelwahed, Sameh H., Begley, Tadhg P.   +3 more
core   +1 more source