Results 51 to 60 of about 945 (112)

Beyond “you are what you eat”: Unlocking gut microbiota‐mediated biotransformation of dietary phytochemicals

open access: yesiMetaOmics, Volume 3, Issue 2, June 2026.
The “efficacy paradox” of phytochemicals, low bioavailability yet significant health benefits, is associated with gut microbiota, which biotransforms dietary precursors into bioactive metabolites, enabling systemic effects. Thus, health outcomes of diet depend not just on intake “the rainbow”, but on gut microbial metabolism, redefining “you are what ...
Peng Yang, Ren‐You Gan
wiley   +1 more source

Harnessing Trace Elements: Novel Radiosensitization Strategies for Enhanced Cancer Radiotherapy

open access: yesRare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Radiotherapy (RT) is one of the core methods of comprehensive cancer treatment. Globally, more than 40% of cancer patients rely on radiotherapy to achieve tumor control, cure or palliative relief. However, radiation resistance, immunosuppression and normal tissue injury limit its clinical application.
Yuhuan Zhang   +6 more
wiley   +1 more source

Effect of Metal Cations on Selenite Bioreduction by a Consortium of Halophilic/Halotolerant Bacteria and/or Yeast

open access: yesEnvironmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Evaluation the effects of potentially toxic co‐contaminating metal cations, including cadmium (Cd), lead (Pb), and Zinc (Zn), on the bioreduction of selenite by a consortium of halotolerant and halophilic bacteria and/or yeast. ABSTRACT Selenium oxyanion pollution in the environment, often originating from anthropogenic industrial activities, causes ...
Elham Lashani   +3 more
wiley   +1 more source

Structural studies of molybdopterin synthase, an essential enzyme for dithiolene formation during molybdenum cofactor biosynthesis

open access: yes, 2007
The molybdenum cofactor is found in a variety of enzymes present in bacteria, plants and animals and is composed of closely related molecules which all contain molybdopterin, a tricyclic pyranopterin containing a cis-dithiolene group.
Daniels, Juma Nkosi
core  

Genomic Survey of Carbon Monoxide Dehydrogenases Reveals Their Widespread Distribution in Marine Habitats

open access: yesEnvironmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Protein sequence surveys show that nickel‐ and molybdenum/copper‐containing carbon monoxide dehydrogenases (CODHs) are widespread in the ocean. Phylogenetic and genome context analyses reveal that marine CODHs are highly diverse in both evolutionary history and functional organisation.
Nipa Chongdar   +2 more
wiley   +1 more source

Redundant and Flexible Electron Transfer Pathways Underlie MsrPQ‐Mediated Repair of Oxidized Periplasmic Proteins

open access: yesMolecular Microbiology, Volume 125, Issue 6, Page 493-505, June 2026.
This study investigates in vivo the role of the flavin reductase Fre as an electron supplier to the periplasmic methionine sulfoxide reductase system MsrPQ. ABSTRACT The MsrPQ system is essential for the repair of oxidized methionine residues in periplasmic proteins, ensuring bacterial resistance to oxidative stress and envelope integrity.
Laurent Loiseau, Benjamin Ezraty
wiley   +1 more source

Molybdopterin biosynthesis - Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP

open access: yes, 2015
The first step in the biosynthesis of the molybdopterin cofactor involves an unprecedented insertion of the purine C8 carbon between the C2′ and C3′ carbons of the ribose moiety of GTP. Here we review mechanistic studies on this remarkable transformation.
Mehta, Angad P.   +2 more
core   +1 more source

Linking NrfD/PsrC‐like architecture to energy conservation: Functional residues in the quinone reactive QrcABCD complex of sulfate‐reducing bacteria

open access: yesProtein Science, Volume 35, Issue 5, May 2026.
Abstract The QrcABCD quinone reductase complex is an electrogenic complex present in sulfate‐reducing bacteria of the Desulfobacterota phylum. It operates as a cytochrome c3:menaquinone oxidoreductase involved in electron transfer from periplasmic hydrogen or formate oxidation to the menaquinone (MK) pool.
Gonçalo Manteigas   +4 more
wiley   +1 more source

Molybdopterin biosynthesis pathway contributes to the regulation of SaeRS two-component system by ClpP in Staphylococcus aureus

open access: yes, 2022
In Staphylococcus aureus, the SaeRS two-component system is essential for the bacterium’s hemolytic activity and virulence. The Newman strain of S. aureus contains a variant of SaeS sensor kinase, SaeS L18P.
Min Li (12799)   +9 more
core   +1 more source

A conditional-lethal molybdopterin-defective mutant of barley

open access: yesMolecular and General Genetics MGG, 1985
The molybdenum cofactor of the barley mutant R9401 is not able to reconstitute NADPH nitrate reductase activity from extracts of the N. crassa nit-1 mutant nor is it able to effect dimerisation of the nitrate reductase subunits present in the R9401 mutant.
Wray, J. L.   +3 more
openaire   +1 more source

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