Results 41 to 50 of about 247,963 (294)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Evaluation of gusset plate moment connection at elevated temperatures using gene expression programming and finite element model

Results in Engineering
In this study, the performance of the gusset plate moment connection under fire conditions is examined using finite element modeling and genetic algorithm. Following validation, the finite element modeling is conducted in three stages.
Hesam Ketabdari, Amir Saedi Daryan
doaj   +1 more source

DC-conductivity of a suspension of insulating particles with internal rotation

, 2009
We analyse the consequences of Quincke rotation on the conductivity of a suspension. Quincke rotation refers to the spontaneous rotation of insulating particles dispersed in a slightly conducting liquid and subject to a high DC electric field: above a ...
E. Lemaire, E. Lemaire, G. Quincke, J.R. Melcher, J.T.K. Wan, K.W. Yu, L. Lobry, N. Pannacci, N. Pannacci, P.E. Secker, R. Tao, Z. Randriamalala   +11 more
core   +3 more sources

H-alpha kinematics of S4G spiral galaxies-II. Data description and non-circular motions [PDF]

, 2015
We present a kinematical study of 29 spiral galaxies included in the Spitzer Survey of Stellar Structure in Galaxies, using Halpha Fabry-Perot data obtained with the Galaxy Halpha Fabry-Perot System instrument at the William Herschel Telescope in La ...
Athanassoula, E., Beckman, John E., Bosma, Albert, Cisternas, Mauricio, Díaz-García, Simón, Elmegreen, Bruce G., Erroz-Ferrer, Santiago, Font, Joan, Ho, Luis C., Kim, Taehyun, Knapen, Johan H., Laurikainen, Eija, Leaman, Ryan, Martinez-Valpuesta, Inma, Meidt, Sharon E., Muñoz-Mateos, Juan Carlos, Salo, Heikki, Sheth, Kartik   +17 more
core   +5 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Nonlinear seismic analysis of steel frame with semi-rigid joints

Građevinar, 2015
The nonlinear seismic analysis of steel frame without diagonals is presented in the paper. The real behaviour of semi-rigid joints is taken into account through prior numerical simulation of the selected type of joint.
Paulina Krolo, Mehmed Čaušević, Mladen Bulić   +2 more
doaj   +1 more source

Field observation and numerical analysis of a rotating pipe in flight

Journal of Fluid Science and Technology, 2018
The present purpose is to reveal the mechanism of a flying pipe from an aerodynamic point of view. At first, we conduct field observations of a flying pipe using a pair of high-speed video cameras, together with three-dimensional motion analyses.
Katsuya HIRATA, Yosuke KIDA, Toshihiro NAKAI, Kouhei MIYAHARA, Yusuke NAITO, Hirochika TANIGAWA, Masami NAKANO   +6 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Calculation Method of Rotational Constraint Stiffness for a New Tower-Pier Connected System

Applied Sciences, 2022
The universal hinge support (UHS) is a new connection system for the tower and pier of a single-tower cable-stayed bridge (STCSB), which could conform the multi-direction rotation of the tower and release the bending moment at the bottom of the tower in ...
Yajun Zhang, Yu Zhao, Yongjun Zhou, Xia Yang   +3 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source