Results 91 to 100 of about 837,539 (338)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar +9 morewiley +1 more sourcePrecision measurements on δ CP in MOMENT
Journal of High Energy Physics, 2019 As it is very promising to expect a discovery of CP violation in the leptonic sector, the precision measurement of the Dirac CP phase δ CP is going to be one of the key interests in the future neutrino oscillation experiments.Jian Tang, Sampsa Vihonen, Tse-Chun Wangdoaj +1 more sourceStrength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra +3 morewiley +1 more sourcePotential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk +4 morewiley +1 more sourceDeveloping evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking +43 morewiley +1 more sourceThe Quantum Wavefunction [PDF]
, 2014 When most people think of physics, they think of what they learned in high
school physics: that the world is fundamentally predictable. Given the position
and velocity of a particle in space, it should be possible to predict its
position at any moment in Jaladanki, Nagaganeshcore Probing exotic phenomena at the interface of nuclear and particle
physics with the electric dipole moments of diamagnetic atoms: A unique
window to hadronic and semi-leptonic CP violation
, 2017 The current status of electric dipole moments of diamagnetic atoms which
involves the synergy between atomic experiments and three different theoretical
areas -- particle, nuclear and atomic is reviewed. Various models of particle
physics that predict CP @@endQCD Collaboration, A. Abdel-Rehim, A. Abdel-Rehim, A. Abdel-Rehim, A. Bacchetta, A. Bartl, A. Courtoy, A. Czarnecki, A. Djouadi, A. Faessler, A. Faessler, A. Maiezza, A. Maiezza, A. Pich, A. Pilaftsis, A. Pilaftsis, A. Pilaftsis, A. Romanino, A. Shindler, A. Yoshimi, A. Yoshimi, A.D. Sakharov, A.J. Buras, A.J. Buras, A.M. Martensson-Pendrill, A.R. Zhitnitsky, A.W. Thomas, ACME Collaboration, ATLAS Collaboration, ATLAS Collaboration, ATLAS Collaboration, ATLAS Collaboration, B. Aubert, B. Borasoy, B. Graner, B. K. Sahoo, B. Li, B. McKellar, B. P. Das, B.C. Regan, B.K. Sahoo, B.K. Sahoo, Belle Collaboration, C. Adolph, C. Alexandrou, C. Alexandrou, C. Dib, C. Hamzaoui, C. Hamzaoui, C. Jarlskog, C. Kao, C.-C. Chiou, C.-P. Liu, C.-Y. Chen, C.-Y. Seng, C.-Y. Seng, C.A. Baker, C.Q. Geng, C.S. Lim, CMS Collaboration, CMS Collaboration, CMS Collaboration, CMS Collaboration, CMS Collaboration, CMS Collaboration, CMS Collaboration, CMS Collaboration, D. Bowser-Chao, D. Chang, D. Chang, D. Chang, D. Chang, D. Chang, D. Chang, D. Chang, D. Cho, D. Cho, D. Demir, D. Demir, D.-L. Yao, D.A. Dicus, D.B. Kaplan, D.K. Hong, D.V. Chubukov, D.V. Nanopoulos, D.V. Nanopoulos, E. Accomando, E. Braaten, E. Braaten, E. Christova, E. Mereghetti, E. Mereghetti, E. Shintani, E. Shintani, E. Shintani, E. Witten, E. Áavarez, E.M. Purcell, E.O. Iltan, E.P. Shabalin, E.P. Shabalin, E.T. Rand, ETM Collaboration, F. Berruto, F. del Aguila, F. del Aguila, F. del Aguila, F. Gabbiani, F. Kuchler, F. Xu, F.-K. Guo, F.-K. Guo, G. Barenboim, G. Barton, G. Beall, G. Boyd, G. Buchalla, G. Degrassi, G. Lüders, G. Senjanovic, G.-C. Cho, G.C. Branco, G.C. Branco, G.F. Giudice, G.R. Farrar, G.S. Bali, H. An, H. Ohki, H.-W. Lin, H.-Y. Cheng, H.-Y. Cheng, H.E. Haber, I. Bigi, I. Bigi, I. Stetcu, I.B. Khriplovich, I.B. Khriplovich, I.B. Khriplovich, I.S. Towner, J. Brod, J. Bsaisou, J. Bsaisou, J. Bsaisou, J. Dai, J. de Vries, J. de Vries, J. de Vries, J. de Vries, J. de Vries, J. de Vries, J. Dobaczewski, J. Donoghue, J. Ellis, J. Ellis, J. Ellis, J. Engel, J. Engel, J. Fan, J. Gasser, J. Gasser, J. Gasser, J. Gasser, J. Hisano, J. Hisano, J. Hisano, J. Hisano, J. Hisano, J. Hisano, J. Hisano, J. Kuckei, J. Ng, J. Polchinski, J.-M. Frère, J.A. Aguilar-Saavedra, J.F. Gunion, J.H. Christenson, J.H. de Jesus, J.J. Hudson, J.L. Hewett, J.M. Alarcon, J.M. Alarcon, J.M. Alarcon, J.M. Arnold, J.M. Pendlebury, J.O. Eeg, J.P. Archambault, J.R. Ellis, J.R. Ellis, J.R. Ellis, J.R. Green, J.S.M. Ginges, JLQCD Collaboration, JLQCD Collaboration, K. Abe, K. Agashe, K. Asahi, K. Cheung, K. Choi, K. Choi, K. Choi, K. Fuyuto, K. Harada, K. Higashiyama, K. Higashiyama, K. Ishiwata, K. Ottnad, K. Takeda, K.A. Olive, K.A. Peterson, K.R. Dienes, K.V.P. Latha, K.V.P. Latha, L. Radziute, L. Tiator, L.I. Schiff, M. Anselmino, M. Bishof, M. Brhlik, M. Brhlik, M. Carena, M. Chemtob, M. Dhuria, M. Dine, M. Dine, M. Drees, M. Dugan, M. Endo, M. Engelhardt, M. Franz, M. González-Alonso, M. Hoferichter, M. Jung, M. Kobayashi, M. König, M. Maniatis, M. Pitschmann, M. Pospelov, M. Pospelov, M. Pospelov, M. Pospelov, M. Pospelov, M. Pospelov, M. Radici, M.A. Rosenberry, M.A. Shifman, M.A. Shifman, M.B. Gavela, M.E. Pospelov, M.E. Pospelov, M.J. Ramsey-Musolf, M.W. Kalinowski, MILC Collaboration, MILC Collaboration, N. Arkani-Hamed, N. Arkani-Hamed, N. Auerbach, N. Auerbach, N. Brambilla, N. Fortson, N. Yamanaka, N. Yamanaka, N. Yamanaka, N. Yamanaka, N. Yamanaka, N. Yamanaka, N. Yamanaka, N. Yamanaka, N. Yamanaka, N. Yamanaka, N. Yamanaka, N. Yamanaka, N. Yoshinaga, N. Yoshinaga, N. Yoshinaga, N. Yoshinaga, N. Yoshinaga, N.F. Ramsey, N.G. Deshpande, O. Lebedev, O.P. Sushkov, P. Gubler, P. Gubler, P. Gubler, P. Herczeg, P. Herczeg, P. Huet, P. Nath, P.F. Perez, P.G.H. Sandars, P.G.H. Sandars, P.J. Mohr, P.M. Junnarkar, Particle Data Group, PNDME Collaboration, QCDSF Collaboration, QCDSF Collaboration, QCDSF Collaboration, QCDSF-UKQCD Collaboration, R. Aaij, R. Arnowitt, R. Arnowitt, R. Barbier, R. Barbieri, R. Contino, R. Dashen, R. Gariato, R.A. Senkov, R.D. Peccei, R.D. Young, R.G. Leigh, R.H. Parker, R.J. Crewther, R.M. Godbole, R.N. Mohapatra, R.N. Mohapatra, RQCD Collaboration, S. Abel, S. Adler, S. Aoki, S. Aoki, S. Ban, S. Davidson, S. Dimopoulos, S. Durr, S. Dürr, S. Inoue, S. Narison, S. Pal, S. Pokorski, S. Weinberg, S. Weinberg, S.-M. Zhao, S.A. Abel, S.A. Abel, S.A.R. Ellis, S.F. King, S.K. Lamoreaux, S.L. Glashow, S.L. Glashow, S.M. Barr, S.M. Barr, S.M. Barr, S.M. Barr, S.Y. Ayazi, S.Y. Ayazi, T. Abe, T. Appelquist, T. Appelquist, T. Appelquist, T. Bhattacharya, T. Bhattacharya, T. Bhattacharya, T. Bhattacharya, T. Bhattacharya, T. Falk, T. Fujita, T. Fukuyama, T. Fukuyama, T. Furukawa, T. Hatsuda, T. Hatsuda, T. Hatsuda, T. Ibrahim, T. Ibrahim, T. Ibrahim, T. Inoue, T. Inui, T. Kadoyoshi, T. Mannel, T. Sato, T.-F. Feng, T.-F. Feng, T.H. West, T.P. Cheng, T.P. Cheng, U. Mahanta, UCNA Collaboration, V. Barger, V. Barone, V. Cirigliano, V. Cirigliano, V. Cirigliano, V. Spevak, V.A. Dzuba, V.A. Dzuba, V.A. Dzuba, V.F. Dmitriev, V.F. Dmitriev, V.M. Belayev, V.M. Belayev, V.M. Khatsimovsky, V.M. Khatsymovsky, V.P. Gudkov, V.V. Flambaum, V.V. Flambaum, V.V. Flambaum, V.V. Flambaum, V.V. Flambaum, W. Altmannshofer, W. Altmannshofer, W. Bernreuther, W. Buchmüller, W. Dekens, W. Dekens, W. Fischler, W. Heil, W.-F. Chang, W.C. Griffith, W.C. Haxton, X. Artru, X.-G. He, X.-G. He, X.-G. He, X.-G. He, X.-G. He, X.-G. He, X.-G. He, X.-L. Ren, Y. Adachi, Y. Aoki, Y. Grossman, Y. Kizukuri, Y. Kizukuri, Y. Li, Y. Li, Y. Liao, Y. Nir, Y. Singh, Y. Singh, Y. Singh, Y. Singh, Y. Singh, Y. Zhang, Y. Zhang, Y.-B. Yang, Y.-B. Yang, Y.-H. Song, Y.Y. Keum, Y.Y. Keum, Z. Ye, Z.-B. Kang +440 morecore +1 more sourceMicrofluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken +7 morewiley +1 more source