Results 51 to 60 of about 221,649 (309)
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Complexity, 2023 In this paper, the pth moment exponential synchronization problems of drive-response stochastic memristor neural networks are studied via a state feedback controller.
Xiaobo Wang +3 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
General Stieltjes moment problems for rapidly decreasing smooth functions [PDF]
, 2017 We give ( necessary and sufficient) conditions on a sequence {f(n)}n(infinity)=0 of functions under which every generalized Stieltjes moment problem integral(infinity)(0) f(n) (x) phi (x) dx = a(n), n epsilon N, has solutions phi epsilon S(R) with ...
Vindas Diaz, Jasson +4 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Applying the Moment Generating Functions to the Study of Probability Distributions [PDF]
Informatică economică, 2007 In this paper, we describe a tool to aid in proving theorems about random variables, called the moment generating function, which converts problems about probabilities and expectations into problems from calculus about function values and derivates.
doaj
Visnik Harkivsʹkogo Nacionalʹnogo Universitetu im. V.N. Karazina. Cepiâ Matematika, Prikladna Matematika i MehanikaThe scalar moment problem was first introduced by T. J. Stieltjes in his work ``Recherches sur les fractions continues'' Annals of the Faculty of Sciences of Toulouse 8, 1--122, (1895).
Б. Е. Медіна-Ернандес
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The Approximate Solution of Some Plane Boundary Value Problems of the Moment Theory of Elasticity
Advances in Mathematical Physics, 2016 We consider a two-dimensional system of differential equations of the moment theory of elasticity. The general solution of this system is represented by two arbitrary harmonic functions and solution of the Helmholtz equation.
Roman Janjgava
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On certain non-unique solutions of the Stieltjes moment problem [PDF]
Discrete Mathematics & Theoretical Computer Science, 2010 We construct explicit solutions of a number of Stieltjes moment problems based on moments of the form ${\rho}_{1}^{(r)}(n)=(2rn)!$ and ${\rho}_{2}^{(r)}(n)=[(rn)!]^{2}$, $r=1,2,\dots$, $n=0,1,2,\dots$, \textit{i.e.} we find functions $W^{(r)}_{1,2}(x)>0$
K. A. Penson +4 more
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