Results 71 to 80 of about 5,331,665 (291)

In Situ Physiologic and Behavioral Monitoring With Digital Sensors for Cerebrovascular Disease: A Scoping Review

Mayo Clinic Proceedings: Digital Health, 2023
Cerebrovascular disease (CeVD) is a leading cause of death and disability worldwide. Early detection of behavioral and physiologic changes associated with CeVD may be critical to improving patient outcomes.
Stephanie J. Zawada, MS, Naser Haj Aissa, MBBS, Gian Marco Conte, MD, PhD, Benjamin D. Pollock, MS, PhD, Arjun P. Athreya, MS, PhD, Bradley J. Erickson, MD, PhD, Bart M. Demaerschalk, MSc, MD   +6 more
doaj  

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Deep Learning-Based Electrocardiogram Signal Noise Detection and Screening Model [PDF]

Healthcare Informatics Research, 2019
ObjectivesBiosignal data captured by patient monitoring systems could provide key evidence for detecting or predicting critical clinical events; however, noise in these data hinders their use. Because deep learning algorithms can extract features without
Dukyong Yoon, Hong Seok Lim, Kyoungwon Jung, Tae Young Kim, Sukhoon Lee   +4 more
doaj   +1 more source

Measuring breath acetone for monitoring fat loss: Review

Obesity, 2015
Endogenous acetone production is a by‐product of the fat metabolism process. Because of its small size, acetone appears in exhaled breath. Historically, endogenous acetone has been measured in exhaled breath to monitor ketosis in healthy and diabetic ...
Joseph C Anderson
semanticscholar   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Inverse Relation between Condition of Heart Failure and Intrathoracic Impedance Measured by Implantable Cardioverter Defibrillator—A case report—

Journal of Arrhythmia, 2005
The patient was a 78-year-old man with dilated cardiomyopathy. His cardio-thoracic ratio was 60.4% and left ventricular ejection fraction (LVEF) was 33%. He had been repeatedly admitted for congestive heart failure.
Kohei Matsushita, MD, Toshiyuki Ishikawa, MD, Shinichi Sumita, MD, Tsukasa Kobayashi, MD, Hideyuki Ogawa, MD, Noriko Inoue, MD, Katsumi Matsumoto, MD, Minoru Taima, MD, Ichirou Nakazawa, MD, Teruyasu Sugano, MD, Tomoaki Ishigami, MD, Kazuaki Uchino, MD, Kazuo Kimura, MD, Satoshi Umemura, MD   +13 more
doaj   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Remote Mobile Health Monitoring System Based on Smart Phone and Browser/Server Structure.

Journal of Healthcare Engineering, 2015
A remote mobile health monitoring system with mobile phone and web service capabilities is proposed in this paper. It provides an end-to-end solution; specifically, (1) physiologic parameters, including respiration rate and heart rate, are measured by ...
Yunzhou Zhang, Huiyu Liu, Xiaolin Su, Pei Jiang, Dongfei Wei   +4 more
semanticscholar   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source