Results 81 to 90 of about 2,600,115 (310)
Physiologic indexes of patients before,during and after visit in coronary care unit at Emam khomaini hospital in Ardebil [PDF]
Background and Aim Visit is an essential issue in hospitals and of patient´s basic needs in coronary care units(CCUs).Howevere there is no evidence regarding its physiologic effects on them.
عزتی, ژاله +5 more
core
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Journal of Preventive, Diagnostic and Treatment Strategies in MedicineDigital health technologies and artificial intelligence (AI) have expanded the capacity for continuous physiologic monitoring during pregnancy. While wearable-derived digital biomarkers are increasingly studied, evidence specific to the early detection ...
Wiku Andonotopo +10 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Participatory Monitoring and Management Partnership
, 2015 The Participatory Monitoring and Management Partnership (PMMP) is an international collaborative network for local leaders and communities working with participatory monitoring and management of natural resources. The Partnership seeks to transform
Participatory Monitoring and Management Partnership
core
, 1998 Objective: To assess whether the provision of computerized physiologic trend data could improve outcome in newborn infants requiring intensive care. Design: Randomized, controlled trial, with subsidiary questionnaire studies.
Cunningham, Steven +4 more
core +1 more source
MC-MED, multimodal clinical monitoring in the emergency department
Scientific DataEmergency Department (ED) patients often present with undiagnosed complaints, and can exhibit rapidly evolving physiology. Therefore, data from continuous physiologic monitoring, in addition to the electronic health record, is essential to understand the
Aman Kansal +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source