Results 221 to 230 of about 6,030,936 (310)

Optimizing sampling across transect-based methods improves the power of agroecological monitoring data. [PDF]

J Environ Qual
McCord SE, Webb NP, Van Zee JW, Courtright EM, Billings B, Duniway MC, Edwards BL, Kachergis E, Moriasi D, Morra B, Nafus A, Newingham BA, Scott DA, Toledo D.   +13 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Exploring Relationships Between Maternal Characteristics, Continuous Glucose Monitoring Data, and Neonatal Hypoglycemia in Gestational Diabetes Pregnancies Using Probabilistic Modeling. [PDF]

J Diabetes Sci Technol
Cappon G, Catanuso M, Tavazzi E, Elkind-Hirsch K, Facchinetti A.   +4 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Stress Concentration-Based Material Leakage Fault Online Diagnosis of Vacuum Pressure Vessels Based on Multiple FBG Monitoring Data. [PDF]

Materials (Basel)
Gong Z, Shen FK, Liu YH, Yan CL, Rui J, Cao PF, Wang HP, Xiang P.   +7 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Occupational Laboratory Exposures to <i>Burkholderia pseudomallei</i> in the United States: A Review of Exposures and Serological Monitoring Data, 2008-2024. [PDF]

Pathogens
Richardson BT, Elrod MG, DeBord KM, Schrodt CA, Thompson JM, Benoit TJ, Liu L, Petras JK, Blaney D, Gee JE, Kraushaar V, Stanek D, Kurkjian KM, Griffin-Thomas L, Pang WG, Garafalo K, Brown CM, Bye M, Egan C, Negron ME, Bower WA, Hoffmaster AR, Weiner ZP, Cossaboom CM.   +23 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Efficiency loss with binary pre-processing of continuous monitoring data. [PDF]

Stat Biosci
Langner PR, Juarez-Colunga E, Marzec LN, Grunwald GK, Rice JD.   +4 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source