Results 101 to 110 of about 150,516 (303)

Machine Learning‐Augmented Loop‐Mediated Isothermal Amplification‐Enabled Point‐of‐Care for Mpox‐Specific Detection

open access: yesAdvanced Intelligent Systems, EarlyView.
A low‐cost, portable point‐of‐care platform for rapid Mpox detection using loop‐mediated isothermal amplification is reported. The device integrates fluorescence readout and mobile monitoring. A machine‐learning model analyzes temperature data and correlates thermal changes with DNA concentration, enabling sensitive and reliable molecular diagnosis in ...
Nazente Atceken   +4 more
wiley   +1 more source

Motor recovery following capsular stroke [PDF]

open access: yes, 1993
The functional anatomy of motor recovery was studied by assessing motor function quantitatively in 23 patients following capsular or striatocapsular stroke.
Danek, Adrian   +3 more
core   +1 more source

Shapley Additive Explanation for Local Class Differentiation: Local Explainability for Class Differentiation in Classification Models

open access: yesAdvanced Intelligent Systems, EarlyView.
An instance‐level, model‐agnostic explanation of class differentiation is introduced through SHAP‐LCD, linking probability shifts to feature‐wise Shapley contributions. The method operates on tabular and image data and is released in a fully reproducible implementation, offering a transparent way to examine, at each instance, why predictive models ...
Roxana M. Romero Luna   +2 more
wiley   +1 more source

Monkeys excluding apes as a model for studies on metabolic syndrome

open access: yesБюллетень сибирской медицины
Aim. To summarize the results of research on metabolic syndrome in monkeys excluding apes and to conduct a comparison with humans.A search for full-text publications in PubMed and Scopus databases was carried out using the following keywords: nonhuman ...
S. V. Orlov   +4 more
doaj   +1 more source

Homologous recombination-mediated targeted integration in monkey embryos using TALE nucleases

open access: yesBMC Biotechnology, 2019
Background Non-human primate (NHP) models can closely mimic human physiological functions and are therefore highly valuable in biomedical research. Genome editing is now developing rapidly due to the precision and efficiency offered by engineered site ...
Chu Chu   +9 more
doaj   +1 more source

AI‐Assisted IoT‐Enabled ECG Monitoring: Integrating Foundational and Generative AI Tools for Sustainable Smart Healthcare—Recent Trends

open access: yesAI &Innovation, EarlyView.
ABSTRACT The rapid evolution of the Internet of Things (IoT) has significantly advanced the field of electrocardiogram (ECG) monitoring, enabling real‐time, remote, and patient‐centric cardiac care. This paper presents a comprehensive survey of AI assisted IoT‐based ECG monitoring systems, focusing on the integration of emerging technologies such as ...
Amrita Choudhury   +2 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

open access: yesAngewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Diagnostic Odyssey of Atypical Long‐Chain 3‐Hydroxyacyl‐CoA Dehydrogenase Deficiency (LCHADD) Explained by Three Allelic Products From Two Pathogenic Variants

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency (LCHADD) is an autosomal recessive mitochondrial defect of long‐chain fatty acid β‐oxidation, caused by biallelic pathogenic variants in HADHA or HADHB. We report a 22‐year‐old male with an atypically mild presentation of LCHADD who was referred to the Undiagnosed Diseases Network (UDN ...
Yutaka Furuta   +9 more
wiley   +1 more source

An Evaluation of the Safety and Immunogenicity of a Recombinant Protein-Based Pneumococcal Vaccine in ICR Mice and Cynomolgus Macaque Models

open access: yesVaccines
Background: Pneumococcal diseases remain a global threat due to the serotype-specific limitations of polysaccharide vaccines. This study evaluated a recombinant protein-based pneumococcal vaccine (PBPV) combining three PspA variants (PRX1/Family1Clade2 ...
Xiuwen Sui   +14 more
doaj   +1 more source

Racism and Aids: African Origin Theories of HIV-1 [PDF]

open access: yes, 1994
The AIDS epidemic, first discovered in the United States in 1981, has caused a great deal of speculation with regard to the origins of both the HIV-1 retrovirus and the early pathways for the epidemic itself. The African origins theory is the most widely
Hunt, Charles W.
core   +1 more source

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