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Strengths and challenges of longitudinal non-human primate neuroimaging [PDF]

NeuroImage, 2021
Longitudinal non-human primate neuroimaging has the potential to greatly enhance our understanding of primate brain structure and function. Here we describe its specific strengths, compared to both cross-sectional non-human primate neuroimaging and ...
Xiaowei Song, Pamela García-Saldivar, Nathan Kindred, Yujiang Wang, Hugo Merchant, Adrien Meguerditchian, Yihong Yang, Elliot A. Stein, Charles W. Bradberry, Suliann Ben Hamed, Hank P. Jedema, Colline Poirier   +11 more
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A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model [PDF]

Advanced Science
There is a pressing demand for neuroregenerative treatment for Alzheimer's disease (AD). Recently, a NeuroD1‐mediated neuroregeneration strategy has been proposed, yet its efficacy remains untested in non‐human primate (NHP) AD models closely reflecting ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
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Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs

Neurobiology of Disease, 2023
Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disease caused by a CAG repeat expansion in exon1 of the huntingtin gene (HTT).
Huichun Tong, Tianqi Yang, Li Liu, Caijuan Li, Yize Sun, Qingqing Jia, Yiyang Qin, Laiqiang Chen, Xianxian Zhao, Gongke Zhou, Sen Yan, Xiao-Jiang Li, Shihua Li   +12 more
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Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig

Frontiers in Cell and Developmental Biology, 2023
Animal models are important for understanding the pathogenesis of human diseases and for developing and testing new drugs. Pigs have been widely used in the research on the cardiovascular, skin barrier, gastrointestinal, and central nervous systems as ...
Yingqi Lin, Caijuan Li, Wei Wang, Jiawei Li, Chunhui Huang, Xiao Zheng, Zhaoming Liu, Xichen Song, Yizhi Chen, Jiale Gao, Jianhao Wu, Jiaxi Wu, Zhuchi Tu, Liangxue Lai, Xiao-Jiang Li, Shihua Li, Sen Yan   +16 more
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Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing

Signal Transduction and Targeted Therapy, 2023
Severe combined immunodeficiency (SCID) encompasses a range of inherited disorders that lead to a profound deterioration of the immune system. Among the pivotal genes associated with SCID, RAG1 and IL2RG play crucial roles.
Xiao Zheng, Chunhui Huang, Yingqi Lin, Bofeng Han, Yizhi Chen, Caijuan Li, Jiawei Li, Yongyan Ding, Xichen Song, Wei Wang, Weien Liang, Jianhao Wu, Jiaxi Wu, Jiale Gao, Chengxi Wei, Xudong Zhang, Zhuchi Tu, Sen Yan   +17 more
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Dynamic Regulation of DNA Methylation and Brain Functions

Biology, 2023
DNA cytosine methylation is a principal epigenetic mechanism underlying transcription during development and aging. Growing evidence suggests that DNA methylation plays a critical role in brain function, including neurogenesis, neuronal differentiation ...
Jiaxiang Xie, Leijie Xie, Huixian Wei, Xiao-Jiang Li, Li Lin   +4 more
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Insights into White Matter Defect in Huntington’s Disease

Cells, 2022
Huntington’s disease (HD) is an autosomal-dominant inherited progressive neurodegenerative disorder. It is caused by a CAG repeat expansion in the Huntingtin gene that is translated to an expanded polyglutamine (PolyQ) repeat in huntingtin protein. HD is
Yize Sun, Huichun Tong, Tianqi Yang, Li Liu, Xiao-Jiang Li, Shihua Li   +5 more
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Genetically modified large animal models for investigating neurodegenerative diseases

Cell & Bioscience, 2021
Neurodegenerative diseases represent a large group of neurological disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, and Huntington’s disease.
Weili Yang, Xiusheng Chen, Shihua Li, Xiao-Jiang Li   +3 more
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A new non-human primate model of desiccating stress-induced dry eye disease

Scientific Reports, 2022
Dry eye disease (DED), a multifactorial ocular surface disease, is estimated to affect up to 34% of individuals over 50 years old. Although numerous animal models, including rodents and rabbits, have been developed to mimic the pathophysiologic ...
Li Gong, Yilin Guan, WonKyung Cho, Baowen Li, Lingzhen Pan, Zhenyan Yang, Mingling Wu, Zunyuan Yang, Sunil K. Chauhan, Wen Zeng   +9 more
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High-titer AAV disrupts cerebrovascular integrity and induces lymphocyte infiltration in adult mouse brain

Molecular Therapy: Methods & Clinical Development, 2023
The brain is often described as an “immune-privileged” organ due to the presence of the blood-brain-barrier (BBB), which limits the entry of immune cells.
Yaowei Guo, Junliang Chen, Wenyu Ji, Liang Xu, Yu Xie, Shu He, Chuying Lai, Kaiyu Hou, Zeru Li, Gong Chen, Zheng Wu   +10 more
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