Results 11 to 20 of about 17,406,766 (301)
Beyond MRI: on the scientific value of combining non-human primate neuroimaging with metadata [PDF]
NeuroImage, 2021 Sharing and pooling large amounts of non-human primate neuroimaging data offer new exciting opportunities to understand the primate brain. The potential of big data in non-human primate neuroimaging could however be tremendously enhanced by combining ...
Colline Poirier +8 more
doaj +5 more sources
Microbiome Studies in Non-human Primates [PDF]
Current HIV/AIDS Reports, 2021 Observations of differing bacterial, intestinal microbiomes in people living with HIV have propelled interest in contributions of the microbiome to HIV disease. Non-human primate (NHP) models of HIV infection provide a controlled setting for assessing contributions of the microbiome by standardizing environmental confounders.
Brenchley, Jason M., Ortiz, Alexandra M.
openaire +2 more sources
The non‐human primate model of tuberculosis [PDF]
Journal of Medical Primatology, 2012 AbstractNon‐human primates (NHPs) are used to model human disease owing to their remarkably similar genomes, physiology, and immune systems. Recently, there has been an increased interest in modeling tuberculosis (TB) in NHPs. Macaques are susceptible to infection with different strains of Mycobacterium tuberculosis (Mtb), producing the full spectrum ...
D, Kaushal +3 more
openaire +2 more sources
A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin
Advanced Science, 2023 Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT) that can be ...
Caijuan Li +16 more
doaj +1 more source
Translational Neurodegeneration, 2023 In order to dissect amyotrophic lateral sclerosis (ALS), a multigenic, multifactorial, and progressive neurodegenerative disease with heterogeneous clinical presentations, researchers have generated numerous animal models to mimic the genetic defects ...
Longhong Zhu +3 more
doaj +1 more source
Animals, 2022 The Chinese tree shrew (Tupaia belangeri chinensis) has the potential to replace the use of non-human primates in biomedical research. To increase the availability of this species, we have undertaken the ambitious task of establishing inbred lines of the
Jia-Qi Chen +7 more
doaj +1 more source
The Ontogeny of Vocal Rhythms in a Non-Human Primate. [PDF]
Dev SciABSTRACT Rhythm is a fundamental aspect of human behaviour, and musical rhythm provides one of its most elaborate instances. Unlike speech, this rhythmic behaviour is characterized by the production of temporal patterns structured around small‐integer ratios, which emerge early in life and change systematically ...
Laffi L +11 more
europepmc +6 more sources
Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys
Signal Transduction and Targeted Therapy, 2023 Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer’s disease.
Zhuchi Tu +13 more
doaj +1 more source
Comparing HD knockin pigs and mice reveals the pathological role of IL-17
Cell Reports, 2023 Summary: Our previous work has established a knockin (KI) pig model of Huntington’s disease (HD) that can replicate the typical pathological features of HD, including selective striatal neuronal loss, reactive gliosis, and axonal degeneration.
Qingqing Jia +13 more
doaj +1 more source
Experimental field studies with non-human primates [PDF]
, 2014 This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 283871.One way to study language evolution is to compare human communication with ...
Zuberbuehler, Klaus +2 more
core +1 more source