Results 41 to 50 of about 67,538 (200)

Efficacy, safety, and dose of Pafuramidine, a new oral drug for treatment of first stage sleeping sickness, in a phase 2a clinical study and phase 2b randomized clinical studies [PDF]

, 2016
Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death.
Carol A. Olson (1807531), Patrick D Yeramian, Bilenge, Constantin Miaka Mia, Pascal Lutumba, Manuel, F, Sonja C Bernhard, Allen, James L., Mpanya, Alain, Alain Mpanya, Blum, Johannes, Lubaki, J P, Richard R Tidwell, Gabriele Pohlig, Constantin Miaka Mia Bilenge, Yeramian, Patrick D., Kazadi Kyanza Serge, Tidwell, R R, Thompson, Mark, Alfred Mpoo Mpoto, Bernhard, Sonja C., Tidwell, Richard R., Christian Burri (141244), Carol A Olson, Sonja C. Bernhard (1807537), Blaise Fungula Munungu, Bernhard, S C, James L Allen, Burri, Christian, Munungu, Blaise Fungula, Olson, Carol A., Francisco Manuel (1807528), Victor Kande Betu Ku Mesu, Constantin Miaka Mia Bilenge (1807513), Lutumba, P, Pohlig, G, Mark Thompson, Francisco Manuel, Blaise Fungula Munungu (1807519), Merolle, Ada, Lutumba, Pascal, Ada Merolle, Mpoto, Alfred Mpoo, Mesu, V K, Christian Burri, Jean-Pierre Fina Lubaki (1807546), Allen, J L, Josenando, Théophilo, Ada Merolle (1807540), Johannes Blum, Josenando, T, Lubaki, Jean-Pierre Fina, Gabriele Pohlig (267149), Pohlig, Gabriele, Bilenge, C M, Blum, J, Manuel, Francisco, Merolle, A, Mesu, Victor Kande Betu Ku, Yeramian, P D, Alfred Mpoo Mpoto (1807534), Serge, K K, Munungu, B F, Alain Mpanya (267142), Mark Thompson (533940), James L. Allen (1807522), Olson, C A, Johannes Blum (141240), Mpoto, A M, Victor Kande Betu Ku Mesu (1807510), Théophilo Josenando (1807516), Mpanya, A, Thompson, M, Patrick D. Yeramian (1807543), Richard R. Tidwell (148409), Théophilo Josenando, Burri, C, Jean-Pierre Fina Lubaki, Serge, Kazadi Kyanza, Kazadi Kyanza Serge (1807525), Pascal Lutumba (116142)   +79 more
core   +1 more source

Experimental Yellow Fever in the Squirrel Monkey (Saimiri spp.): Hematological, Biochemical, and Immunological Findings

, 2023
Between 2016 and 2018, Brazil experienced the largest sylvatic epidemic of yellow fever virus (YFV). Despite to the magnitude and rapid spread of the epidemic, little is known about YFV dispersion.
Maria Nazaré O. Freitas, Karla F. L. de Melo, Milene S. Ferreira, Wellington B. da Silva, Aline A. Imbeloni, Luiz A. D. de Queiroz, Robert B. Tesh, Lívia C. Martins, Éder B. dos Santos, Liliane L. Chagas, Camille F. de Oliveira, Pedro F. C. Vasconcelos, Márcia B. M. Luz, José Augusto P. C. Muniz   +13 more
core   +1 more source

A single-cell transcriptomic landscape of primate arterial aging

Nature Communications, 2020
Our understanding of how aging affects the cellular and molecular components of the vasculature and contributes to cardiovascular diseases is still limited.
Weiqi Zhang, Shu Zhang, Pengze Yan, Jie Ren, Moshi Song, Jingyi Li, Jinghui Lei, Huize Pan, Si Wang, Xibo Ma, Shuai Ma, Hongyu Li, Fei Sun, Haifeng Wan, Wei Li, Piu Chan, Qi Zhou, Guang-Hui Liu, Fuchou Tang, Jing Qu   +19 more
doaj   +1 more source

An experimental study on (131)I-CHIBA-1001: a radioligand for α7 nicotinic acetylcholine receptors. [PDF]

PLoS ONE, 2013
OBJECTIVE: The α7 nicotinic acetylcholine receptors (nAChRs) play a vital role in the pathophysiology of neuropsychiatric diseases such as Alzheimer's disease and depression.
Lei Yin, Qian Zhao, Ling Li, Su Lei Zhang, Xue Qi Chen, Chao Ma, Lei Kang, Meng Liu, Chun Li Zhang, Ping Yan, Rong Fu Wang   +10 more
doaj   +1 more source

Assessing the microbial diversity and proximate composition of smoked-fermented bushmeat from four different bushmeat samples

BioTechnologia
The ever-increasing demand for wildlife-derived raw or processed meat commonly known as bushmeat, has been identified as one of the critical factors driving the emergence of infectious diseases.
Afia Sakyiwaa Amponsah, Gloria Mathanda Ankar-Brewoo, Herman Erick Lutterodt, Isaac Williams Ofosu   +3 more
doaj   +1 more source

Brainstem : neglected locus in neurodegenerative diseases

, 2011
The most frequent neurodegenerative diseases (NDs) are Alzheimer’s disease (AD), Parkinson’s disease (PD), and frontotemporal lobar degeneration associated with protein TDP-43 (FTLD–TDP).
Lea Tenenholz Grinberg, Lea T Grinberg, Helmut Heinsen, Udo eRueb, Udo Rueb, Tenenholz Grinberg, Lea, Heinsen, Helmut, Rüb, Udo, Helmut eHeinsen   +8 more
core   +1 more source

Survival of Human Induced Pluripotent Stem Cell–Derived Midbrain Dopaminergic Neurons in the Brain of a Primate Model of Parkinson's Disease

Journal of Parkinson’s Disease, 2011
Before induced pluripotent stem cells (iPSCs) can be used to treat neurologic diseases, human iPSC-derived neural cells must be analyzed in the primate brain.
Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hirotaka Onoe, Takuya Hayashi, Toshiyuki Kawasaki, Hidemoto Saiki, Susumu Miyamoto, Jun Takahashi   +8 more
doaj   +1 more source

Live Viral Vaccine Neurovirulence Screening: Current and Future Models

Vaccines, 2021
Live viral vaccines are one of the most successful methods for controlling viral infections but require strong evidence to indicate that they are properly attenuated.
Corey May Fulton, Wendy J. Bailey
doaj   +1 more source

Establishment of an induced pluripotent stem cell line (cmESF-iPSC-C3) from cynomolgus monkey ear fibroblasts

Stem Cell Research
Induced pluripotent stem cells (iPSCs) derived from cynomolgus monkey (crab-eating macaque) ear fibroblasts offer a minimally invasive and ethically acceptable source of cells for autologous therapies and preclinical research.
Seo-Hyun An, Ji-Yeon Kim, Xing Zhen, Gyu-Seo Bae, Young-Hyun Kim, Sang-Je Park, Jong-Hee Lee   +6 more
doaj   +1 more source

A Robust Single Primate Neuroepithelial Cell Clonal Expansion System for Neural Tube Development and Disease Studies

Stem Cell Reports, 2016
Developing a model of primate neural tube (NT) development is important to promote many NT disorder studies in model organisms. Here, we report a robust and stable system to allow for clonal expansion of single monkey neuroepithelial stem cells (NESCs ...
Xiaoqing Zhu, Bo Li, Zongyong Ai, Zheng Xiang, Kunshang Zhang, Xiaoyan Qiu, Yongchang Chen, Yuemin Li, Joshua D. Rizak, Yuyu Niu, Xintian Hu, Yi Eve Sun, Weizhi Ji, Tianqing Li   +13 more
doaj   +1 more source