Results 71 to 80 of about 67,538 (200)

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

, 2014
SummaryMonkeys serve as important model species for studying human diseases and developing therapeutic strategies, yet the application of monkeys in biomedical researches has been significantly hindered by the difficulties in producing animals ...
Zhou, Qi, Li, Wei, Cui, Yiqiang, Ji, Shaohui, Ji, Weizhi, Sha, Jiahao, Si, Wei, Xiang, Andy Peng, Huang, Xingxu, Shen, Bin, Zhou, Jiankui, Zhou, Zuomin, Wang, Fang, Chen, Yongchang, Hu, Bian, Wang, Jianying, Si, Chenyang, Li, Tianqing, Niu, Yuyu, Kang, Yu, Dong, Guoying, Wang, Hong, Guo, Xuejiang, Pu, Xiuqiong, Wang, Lei, Zhao, Xiaoyang, Bi, Ye, Tan, Tao   +27 more
core   +1 more source

An Evaluation of the Safety and Immunogenicity of a Recombinant Protein-Based Pneumococcal Vaccine in ICR Mice and Cynomolgus Macaque Models

Vaccines
Background: Pneumococcal diseases remain a global threat due to the serotype-specific limitations of polysaccharide vaccines. This study evaluated a recombinant protein-based pneumococcal vaccine (PBPV) combining three PspA variants (PRX1/Family1Clade2 ...
Xiuwen Sui, Ying Yang, Qingfu Xu, Xiao Xu, Dongxia Zhang, Kang Li, Jiangjiao Li, Qingshan Mo, Junqiang Li, Bo Hao, Weixue Si, Jianming Shi, Zhongqi Shao, Xuefeng Yu, Tao Zhu   +14 more
doaj   +1 more source

Toll-like Interleukin -1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs

Journal of Inflammation Research, 2022
Mohammad Abul Kashem,1– 3 Lin Li,2 Xin-Yong Yuan,2 Francis A Plummer1 ,† Ma Luo1,2 1Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada; 2JC Wilt Infectious Diseases Research Center, National ...
Kashem MA, Li L, Yuan XY, Plummer FA, Luo M   +4 more
doaj  

Hemotropic mycoplasma in a free-ranging black howler monkey (Alouatta caraya) in Brazil

, 2013
Hemotropic mycoplasmas are bacteria that infect erythrocytes and cause subclinical infections to life-threatening disease. We describe hemotropic mycoplasma infection in a free-ranging black howler monkey (Alouatta caraya).
Marcondes, Mary [UNESP], Santos, Leonilda C., Oliveira, Marcos J., Estrada, Marko, Leutenegger, Christian M., Sykes, Jane E., Biondo, Alexander W., Cubilla, Michelle P., de Moraes, Wanderlei, Marcondes, Mary, Cubas, Zalmir S., Lindsay, LeAnn L., Filho, Ivan R. Barros   +12 more
core   +1 more source

Epidemiological Survey and Risk Factor Analysis of 14 Potential Pathogens in Golden Snub-Nosed Monkeys at Shennongjia National Nature Reserve, China

, 2023
Golden snub-nosed monkeys (Rhinopithecus roxellanae) belong to Class A, the highest level of endangered primate species. Exploring the infection status of potential pathogens in golden snub-nosed monkeys is important for controlling associated diseases ...
Ian Duncan Robertson, Aizhen Guo, Changmin Hu, Wanji Yang, Feng Wu, Xiang Li, Qiankun Wang, Huanchun Chen, Muhammad Zubair, Yingyu Chen, Tianpeng Huang, Ali Sobhy Dawood, Jianguo Chen, Yu Wang, Mingpu Qi   +14 more
core   +1 more source

Derivation and characterization of monkey embryonic stem cells

, 2004
Embryonic stem (ES) cell based therapy carries great potential in the treatment of neurodegenerative diseases. However, before clinical application is realized, the safety, efficacy and feasibility of this therapeutic approach must be established in ...
K-Y Francis Pau, Don P Wolf, Wolf Don P, Pau K-Y Francis   +3 more
core   +1 more source

Efficient AAV8 delivery to the liver via isolated hepatic perfusion and analysis of hepatic lobule transduction patterns

Liver Research
Background and aims: Adeno-associated virus (AAV) is becoming an attractive vector due to its low toxicity and minimal immunogenicity. However, liver-targeted AAV gene therapy still faces challenges, such as low delivery efficiency and safety risks ...
Chao Wang, Mingming Fan, Jianrong Liu, Xiaolu Guo, Zhipeng Tan, Xueying Huang, Zhuoran Li, Xiaomei Liu, Ye Zhang, Jianqi Feng, Rui Fang, Li Wang, Qiong Ke   +12 more
doaj   +1 more source

Effect of Instructional Guidelines on pregnant women's knowledge and Self-Care Practice regarding MonkeyPox Virus Infection [PDF]

Egyptian Journal of Health Care
Background: Monkey-pox is a rare disease caused by infection with the monkeypox virus. Although monkeypox existed and declined in the past, its re-emergence is simultaneous with the rise in cases recently.Aim: To evaluate the effect of instructional ...
Faten Said Abdelhady Garf, Amal Sarhan Genedy, Samar ElrefaeyElrefaeyAbaza, Sahar SayedAbd El-Ghafar Mohamed, Rasha El -Sayed Ibrahim   +4 more
doaj   +1 more source

Metagenomic Study of Enteric Viruses in Proboscis Monkey (Nasalis larvatus) [PDF]

, 2019
Proboscis monkey (Nasalis larvatus), endemic to Borneo, is listed as “Endangered” species by the International Union for Conservation of Nature (IUCN). Non-human primates are known to be the natural hosts for a variety of virus and bacteria, which some ...
Ng, Kar Hon
core  

Pharmacological properties of the rhesus macaque monkey P2X7 receptor

, 2011
BACKGROUND AND PURPOSE The human P2X7 (hP2X7) receptor exhibits striking pharmacological differences from its rodent counterparts, particularly in terms of its antagonist profile.
Jiang, Lin Hua, Liam E Browne, Browne, Liam E., Helen J Bradley, Wei Yang, Lin‐Hua Jiang, Bradley, Helen J., Yang, Wei   +7 more
core   +1 more source