Results 161 to 170 of about 5,459 (175)
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Monoacylglycerol Lipase Modulators for Treating Autism Spectrum Disorders
ACS Medicinal Chemistry Letters, 2023Provided herein are monoacylglycerol lipase modulators, pharmaceutical compositions, use of such compounds in treating autism spectrum disorders and processes for preparing such compounds.
Ram W. Sabnis, Anika R. Sabnis
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982
Highly purified rat hepatic lipase (NaCl-resistant, alkaline pH optimum) was studied to evaluate whether the enzyme has triacylglycerol lipase, monoacylglycerol lipase and phospholipase activities. Enzyme exhibiting a single band by SDS-polyacrylamide gel electrophoresis and having a specific activity eight times greater than that in any previous ...
G L, Jensen, B, Daggy, A, Bensadoun
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Highly purified rat hepatic lipase (NaCl-resistant, alkaline pH optimum) was studied to evaluate whether the enzyme has triacylglycerol lipase, monoacylglycerol lipase and phospholipase activities. Enzyme exhibiting a single band by SDS-polyacrylamide gel electrophoresis and having a specific activity eight times greater than that in any previous ...
G L, Jensen, B, Daggy, A, Bensadoun
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Monoacylglycerol lipase (MAGL) as a promising therapeutic target
Biochemical Pharmacology, 2018Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2-AG). Besides this role, MAGL has progressively acquired a growing importance as an integrative metabolic hub that controls not only the in vivo levels of 2-AG but also of other ...
Ana, Gil-Ordóñez +3 more
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Lipoprotein lipase and monoacylglycerol lipase activities during maturation of ob17 preadipocytes
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1981Lipoprotein lipase and monoacylglycerol lipase activities of developing ob17 preadipocytes were assayed through the selective inhibition of the former activity by 0.4% Triton X-100. After confluence both enzymes rose tao a peak activity around 13--15 days which was enhanced in insulin-treated cells.
M G, Murphy, R, Négrel, G, Ailhaud
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The Medicinal Chemistry of Agents Targeting Monoacylglycerol Lipase
Current Topics in Medicinal Chemistry, 2008Monoacylglycerol lipase (MAGL) has been recently proposed as the main enzymatic activity responsible for the in vivo hydrolysis of the most abundant endocannabinoid in the brain, the 2-arachidonoylglycerol (2-AG). The endocannabinoids, mainly anandamide (AEA) and 2-AG, are a class of lipid messengers that modulate a broad number of physiological ...
Alma, Viso +2 more
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Lipase-catalyzed syntheses of monoacylglycerols
Enzyme and Microbial Technology, 1995The application of lipases for the production of monoacylglycerols is reviewed. Glycerolysis or selective hydrolysis of fats and oils, esterification of fatty acids or esters with glycerol, and reactions employing protected glycerols are presented. From the most recent literature, reaction systems ranging from organic solvents to reverse micelles and ...
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Lipase-catalyzed synthesis of monoacylglycerol in a homogeneous system
Biotechnology Letters, 2003The 1,3-regiospecifique lipase, Lipozyme IM, catalyzed the esterification of lauric acid and glycerol in a homogeneous system. To overcome the drawback of the insolubility of glycerol in hexane, which is extensively used in enzymatic synthesis, a mixture of n-hexane/tert-butanol (1:1, v/v) was used leading to a monophasic system.
Julieta B, Monteiro +2 more
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Monoacylglycerol lipase inhibition as potential treatment for interstitial cystitis
Medical Hypotheses, 2019Interstitial cystitis is a chronic inflammatory condition of the urinary bladder with an unclear etiology. Currently, there are no widely accepted long-term treatment options available for patients with IC, with the European Association of Urology (EAU, 2017 guidelines), American Urology Association (AUA, 2014 guidelines), and the Royal College of ...
Anu, Chinnadurai +6 more
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Characterization of monoacylglycerol lipase (MGL) inhibitor URB602
2007Society for Neuroscience's 37th Annual Meeting 244.4 (Poster 24) San Diego - CA - USA 12-16 Nov ...
KING AR +8 more
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