Dissecting the High Esterase/Lipase Activity and Probiotic Traits in <i>Lactiplantibacillus plantarum</i> B22: A Genome-Guided Functional Characterization. [PDF]
Chai Y +9 more
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Discovery of MAGL Inhibition by Lophine Derivatives: An Unexpected Finding from Chemiluminescent Assay Development. [PDF]
Ottria R +4 more
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Identification of a Possible Endocannabinoid-Mediated Mechanism of Action of Cetylated Fatty Acids. [PDF]
Bononi G +3 more
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Integrating co-expression network analysis and machine learning to reveal the regulatory landscape of <i>GPD</i> genes in <i>Chlamydomonas reinhardtii</i> under salinity stress. [PDF]
Tzec-Interian JA +3 more
europepmc +1 more source
Novel Pyrazolopyridine Inhibitors of Monoacylglycerol Lipase for the Treatment of Neurodegenerative Diseases and Neuroinflammation. [PDF]
Rosse G.
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Monoacylglycerol lipase activity in cardiac myocytes
Biochemistry and Cell Biology, 1988Monoacylglycerol lipase activity in homogenates of isolated myocardial cells (myocytes) from rat hearts was recovered in both particulate and soluble subcellular fractions. The activity present in the microsomal (100 000 × g pellet) fraction was solubilized by treatment with Triton X-100 and combined with the 100 000 × g supernatant fraction; the ...
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The presence of monoacylglycerol lipase was established in extracts of acetone-dried powders from rat and bovine brains using thioester substrate analogs. At pH 7.4, the apparent Km and Vmax values for 1-S-decanoyl-1-mercapto-2,3-propanediol were 56 microM and 227 nmol/h/mg protein in bovine gray matter.
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Monoacylglycerol Lipase Modulators for Treating Autism Spectrum Disorders
ACS Medicinal Chemistry Letters, 2023Provided herein are monoacylglycerol lipase modulators, pharmaceutical compositions, use of such compounds in treating autism spectrum disorders and processes for preparing such compounds.
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Highly purified rat hepatic lipase (NaCl-resistant, alkaline pH optimum) was studied to evaluate whether the enzyme has triacylglycerol lipase, monoacylglycerol lipase and phospholipase activities. Enzyme exhibiting a single band by SDS-polyacrylamide gel electrophoresis and having a specific activity eight times greater than that in any previous ...
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