Monoacylglycerol lipases - Open Access .click

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A Review on the Monoacylglycerol Lipase: At the Interface Between Fat and Endocannabinoid Signalling

Current Medicinal Chemistry, 2010
Together with anandamide, 2-arachidonoylglycerol (2-AG) constitutes one of the main representatives of a family of endogenous lipids known as endocannabinoids. These act by binding to CB(1) and CB(2) cannabinoid receptors, the molecular target of the psychoactive compound Delta(9)-THC, both in the periphery and in the central nervous system, where they
Labar, G., Wouters, J., Lambert, D. M.
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The Medicinal Chemistry of Agents Targeting Monoacylglycerol Lipase

Current Topics in Medicinal Chemistry, 2008
Monoacylglycerol lipase (MAGL) has been recently proposed as the main enzymatic activity responsible for the in vivo hydrolysis of the most abundant endocannabinoid in the brain, the 2-arachidonoylglycerol (2-AG). The endocannabinoids, mainly anandamide (AEA) and 2-AG, are a class of lipid messengers that modulate a broad number of physiological ...
Alma, Viso +2 more
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Lipase-catalyzed syntheses of monoacylglycerols

Enzyme and Microbial Technology, 1995
The application of lipases for the production of monoacylglycerols is reviewed. Glycerolysis or selective hydrolysis of fats and oils, esterification of fatty acids or esters with glycerol, and reactions employing protected glycerols are presented. From the most recent literature, reaction systems ranging from organic solvents to reverse micelles and ...
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MONOACYLGLYCEROL LIPASE MODULATORS