Results 161 to 170 of about 3,551 (187)
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Properties of monoacylglycerol lipase in rabbit aorta
Lipids, 1987AbstractMonoacylglycerol lipase activity was characterized in a soluble preparation from rabbit aorta (intima‐media) obtained by combining a 100,000×g supernatant fraction with activity solubilized from the 100,000×g precipitate fraction by treatment with Triton X‐100.
M, Hee-Cheong, D L, Severson
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Neurochemical Pathology, 1984
The presence of monoacylglycerol lipase was established in extracts of acetone-dried powders from rat and bovine brains using thioester substrate analogs. At pH 7.4, the apparent Km and Vmax values for 1-S-decanoyl-1-mercapto-2,3-propanediol were 56 microM and 227 nmol/h/mg protein in bovine gray matter.
J, Strosznajder, H, Singh, L A, Horrocks
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The presence of monoacylglycerol lipase was established in extracts of acetone-dried powders from rat and bovine brains using thioester substrate analogs. At pH 7.4, the apparent Km and Vmax values for 1-S-decanoyl-1-mercapto-2,3-propanediol were 56 microM and 227 nmol/h/mg protein in bovine gray matter.
J, Strosznajder, H, Singh, L A, Horrocks
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A Review on the Monoacylglycerol Lipase: At the Interface Between Fat and Endocannabinoid Signalling
Current Medicinal Chemistry, 2010Together with anandamide, 2-arachidonoylglycerol (2-AG) constitutes one of the main representatives of a family of endogenous lipids known as endocannabinoids. These act by binding to CB(1) and CB(2) cannabinoid receptors, the molecular target of the psychoactive compound Delta(9)-THC, both in the periphery and in the central nervous system, where they
Labar, G., Wouters, J., Lambert, D. M.
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The Role of Monoacylglycerol Lipase (MAGL) in the Cancer Progress
Cell Biochemistry and Biophysics, 2014In recent years, metabolism is talked highly important in cancer research, especially the lipid metabolism. Researchers believe that the de novo fatty acid synthesis plays an important role in tumor development, while many studies illustrated that Endocannabinoids have anti-tumorigenic actions, including anti-proliferation, apoptosis induction, and ...
Hong, Qin, Zhi-hua, Ruan
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The Medicinal Chemistry of Agents Targeting Monoacylglycerol Lipase
Current Topics in Medicinal Chemistry, 2008Monoacylglycerol lipase (MAGL) has been recently proposed as the main enzymatic activity responsible for the in vivo hydrolysis of the most abundant endocannabinoid in the brain, the 2-arachidonoylglycerol (2-AG). The endocannabinoids, mainly anandamide (AEA) and 2-AG, are a class of lipid messengers that modulate a broad number of physiological ...
Alma, Viso +2 more
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Monoacylglycerol lipase (MAGL) as a promising therapeutic target
Biochemical Pharmacology, 2018Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2-AG). Besides this role, MAGL has progressively acquired a growing importance as an integrative metabolic hub that controls not only the in vivo levels of 2-AG but also of other ...
Ana, Gil-Ordóñez +3 more
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Monoacylglycerol Lipase Modulators for Treating Autism Spectrum Disorders
ACS Medicinal Chemistry Letters, 2023Provided herein are monoacylglycerol lipase modulators, pharmaceutical compositions, use of such compounds in treating autism spectrum disorders and processes for preparing such compounds.
Ram W. Sabnis, Anika R. Sabnis
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Lipase-catalyzed synthesis of monoacylglycerol in a homogeneous system
Biotechnology Letters, 2003The 1,3-regiospecifique lipase, Lipozyme IM, catalyzed the esterification of lauric acid and glycerol in a homogeneous system. To overcome the drawback of the insolubility of glycerol in hexane, which is extensively used in enzymatic synthesis, a mixture of n-hexane/tert-butanol (1:1, v/v) was used leading to a monophasic system.
Julieta B, Monteiro +2 more
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Lipase-catalyzed syntheses of monoacylglycerols
Enzyme and Microbial Technology, 1995The application of lipases for the production of monoacylglycerols is reviewed. Glycerolysis or selective hydrolysis of fats and oils, esterification of fatty acids or esters with glycerol, and reactions employing protected glycerols are presented. From the most recent literature, reaction systems ranging from organic solvents to reverse micelles and ...
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