Results 11 to 20 of about 112,050 (329)

Molecular aspects of monoamine oxidase B [PDF]

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2016
Monoamine oxidases (MAO) influence the monoamine levels in brain by virtue of their role in neurotransmitter breakdown. MAO B is the predominant form in glial cells and in platelets.
Ramsay, Rona Ruth
core   +5 more sources

Monoamine Oxidase B in Cancers: Implications for Therapeutics and Prognosis [PDF]

Journal of Inflammation Research
Yu Liu,1,* Daosheng Li,2,* Changpeng Xie,3,* Yuanming Pan,4 Qing Shi1 1Department of Hepatology, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang No.1 People’s Hospital, Jiujiang, Jiangxi, 332001, People’s Republic of China;
Liu Y, Li D, Xie C, Pan Y, Shi Q
doaj   +2 more sources

Structure-Activity Relationship Analysis of 3-Phenylcoumarin-Based Monoamine Oxidase B Inhibitors

Frontiers in Chemistry, 2018
Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine. Accordingly, small-molecule MAO-B inhibitors potentially alleviate the symptoms of dopamine-linked neuropathologies such as depression ...
Sanna Rauhamäki, Pekka A. Postila, Sanna Niinivehmas, Sami Kortet, Sami Kortet, Emmi Schildt, Emmi Schildt, Mira Pasanen, Elangovan Manivannan, Elangovan Manivannan, Mira Ahinko, Pasi Koskimies, Niina Nyberg, Pasi Huuskonen, Elina Multamäki, Markku Pasanen, Risto O. Juvonen, Hannu Raunio, Juhani Huuskonen, Olli T. Pentikäinen, Olli T. Pentikäinen   +20 more
doaj   +2 more sources

Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

Alzheimer’s Research & Therapy, 2017
Background 18F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of 18F-THK5351 retention in brain regions thought to contain negligible concentrations of PHF raise questions about
Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Joseph Therriault, Min Su Kang, Monica Shin, Marie-Christine Guiot, Qi Guo, Ryuichi Harada, Robert A. Comley, Gassan Massarweh, Jean-Paul Soucy, Nobuyuki Okamura, Serge Gauthier, Pedro Rosa-Neto   +14 more
doaj   +2 more sources

Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice. [PDF]

Clin Sci (Lond), 2023
Wang SH, Tsai FC, Lin HH, Yu TY, Kuo CH, Li HY, Lin MS.   +6 more
europepmc   +3 more sources

Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors. [PDF]

Sci Rep, 2022
Sudevan ST, Oh JM, Abdelgawad MA, Abourehab MAS, Rangarajan TM, Kumar S, Ahmad I, Patel H, Kim H, Mathew B.   +9 more
europepmc   +3 more sources

PET Evaluation of the Novel F-18 Labeled Reversible Radioligand [¹⁸F]GEH200449 for Detection of Monoamine Oxidase-B in the Non-Human Primate Brain. [PDF]

ACS Chem Neurosci, 2023
Varnäs K, Nag S, Halldin C, Farde L.
europepmc   +2 more sources

Role of Monoamine Oxidase Activity in Alzheimer’s Disease: An Insight into the Therapeutic Potential of Inhibitors

Molecules, 2021
Despite not being utilized as considerably as other antidepressants in the therapy of depression, the monoamine oxidase inhibitors (MAOIs) proceed to hold a place in neurodegeneration and to have a somewhat broad spectrum in respect of the treatment of ...
Tapan Behl, Dapinder Kaur, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Gokhan Zengin, Felicia Liana Andronie-Cioara, Mirela Marioara Toma, Simona Bungau, Adrian Gheorghe Bumbu   +9 more
doaj   +1 more source

Molecular docking approach of monoamine oxidase B inhibitors for identifying new potential drugs: Insights into drug-protein interaction discovery [PDF]

Journal of Cell and Molecular Research, 2013
Monoamine oxidase (EC, 1.4.3.4) or amine oxidoreductase catalyzes the oxidative deamination of biogenic amines. Abnormal action of the monoamine oxidase B has been associated with neurological dysfunctions including parkinson´s disorder.
Salimeh Raeisi
doaj   +1 more source

Flavinylation of Monoamine Oxidase B [PDF]

Journal of Biological Chemistry, 1995
Monoamine oxidase B (MAO B) catalyzes the oxidative deamination of biogenic and xenobiotic amines. The oxidative step is coupled to the reduction of an obligatory cofactor, FAD, which is covalently linked to the enzyme at Cys397. In this study, we developed a novel riboflavin-depleted (Rib-) COS-7 cell line to study the flavinylation of MAO B. ApoMAO B
B P, Zhou, D A, Lewis, S W, Kwan, C W, Abell   +3 more
openaire   +2 more sources