Results 261 to 270 of about 112,050 (329)

Type B Monoamine Oxidase and Neurotoxins

European Neurology, 1993
The biochemical process underlying Parkinson's disease is dopamine cell death of the nigrostriatal system. The age-dependent cell death is now proposed to be elicited by the formation of free hydroxy radicals which are formed from hydrogen peroxide, a product of oxidation of dopamine by monoamine oxidase, especially type B.
Makoto Naoi, Makoto Naoi, Wakako Maruyama, Wakako Maruyama   +3 more
openaire   +2 more sources

Monoamine oxidase‐B inhibitors as potential neurotherapeutic agents: An overview and update

Medicinal research reviews (Print), 2019
Monoamine oxidase (MAO) inhibitors have made significant contributions and remain an indispensable approach of molecular and mechanistic diversity for the discovery of antineurodegenerative drugs.
R. Tripathi, S. R. Ayyannan
semanticscholar   +1 more source

Reactive gliosis and monoamine oxidase B

1994
A double-staining method was applied to cryosections of human spinal cord from patients who died with amyotrophic lateral sclerosis (ALS) and corresponding controls in order to investigate cellular content of monoamine oxidase B (MAO-B). 3H-L-Deprenyl emulsion autoradiography was used in combination with histochemical methods for the detection of ...
J, Ekblom, S S, Jossan, L, Oreland, E, Walum, S M, Aquilonius   +4 more
openaire   +2 more sources

Monoamine Oxidase-B Inhibition in Alzheimer's Disease

NeuroToxicology, 2004
Alzheimer's disease (AD) is the most common cause of dementia in late life. There is still no clear-cut consensus whether this disease involves genetic or environmental factors or both. There is a great need to find a way to delay the disease, as delaying the onset of the disease will bring a great relieve on social and medical resources. The monoamine
Peter, Riederer, Walter, Danielczyk, Edna, Grünblatt   +2 more
openaire   +2 more sources

Monoamine oxidase B, smoking, and Parkinson's disease

Journal of the Neurological Sciences, 1986
Idiopathic Parkinson's disease (PD) has been reported to occur more commonly among non-smokers than among cigarette smokers, for reasons that are unknown. PD may possibly be caused by one or more unidentified neurotoxins which chemically resemble N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a substance which after conversion to an active ...
V W, Yong, T L, Perry
openaire   +2 more sources

Monoamine oxidase A and monoamine oxidase B activities are catalyzed by different proteins

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1985
Monoamine oxidases A and B (amino: oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3.4) have been identified in the outer membranes of rat liver mitochondria by their covalent reaction with the inhibitor, [3H]pargyline. On analysis by polyacrylamide gel electrophoresis under denaturing conditions.
D, Smith, C, Filipowicz, R, McCauley
openaire   +2 more sources

Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement?

Expert Opinion on Drug Discovery, 2019
Introduction: Selective monoamine oxidase-B (MAO-B) inhibitors are currently used as coadjuvants for the treatment of early motor symptoms in Parkinson’s disease.
Paolo Guglielmi, S. Carradori, Alessandra Ammazzalorso, D. Secci   +3 more
semanticscholar   +1 more source

Styrene inhibits monoamine oxidase A, but not monoamine oxidase B in monkey brain mitochondria

Toxicology Letters, 2000
The effects of styrene on mitochondrial monoamine oxidase (MAO) activity in rat and monkey brains were compared in vitro. After preincubation at 25 degrees C for 20 min with 1 mM styrene monomer MAO-A activity in monkey brain was inhibited potently using 5-HT (for MAO-A substrate), but MAO-B activity in monkey brain and platelets were slightly ...
T, Egashira, F, Takayama, K, Sakai, Y, Yamanaka   +3 more
openaire   +2 more sources

Ligand fishing of anti-neurodegenerative components from Lonicera japonica using magnetic nanoparticles immobilised with monoamine oxidase B.

Journal of Separation Science, 2019
In this work, monoamine oxidase B was immobilised onto magnetic nanoparticles to prepare a new type of affinity solid-phase extraction adsorbent, which was used to extract the possible anti-neurodegenerative components from the Lonicera japonica flower ...
Gui-Fang Wu, Xiao-lan Jiang, Y. Gong, Yadan Hu, Xiao-Lin Bai, X. Liao   +5 more
semanticscholar   +1 more source

Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats

European Journal of Neuroscience, 2006
AbstractAlthough nicotine is considered to be responsible for the addictive properties of tobacco, growing evidence underlines the importance of non‐nicotine components in smoking reinforcement. It has been shown that tobacco smoke contains monoamine oxidase (MAO) A and B inhibitors and decreases MAO‐A and MAO‐B activity in smokers.
Karine, Guillem, Caroline, Vouillac, Marc R, Azar, Loren H, Parsons, George F, Koob, Martine, Cador, Luis, Stinus   +6 more
openaire   +2 more sources