Results 21 to 30 of about 112,050 (329)

Monoamine oxidase B rs1799836 G allele polymorphism is a risk factor for early development of levodopa-induced dyskinesia in Parkinson's disease

eNeurologicalSci, 2020
Background: Dopamine replacement therapy is an established treatment for motor symptoms of Parkinson's disease, but its long-term use is often limited by the eventual development of motor complications, including levodopa-induced dyskinesia.
Shoko Kakinuma, Minako Beppu, Setsu Sawai, Akitoshi Nakayama, Shigeki Hirano, Yoshitaka Yamanaka, Tatsuya Yamamoto, Chigusa Masafumi, Xiamuxiya Aisihaer, Alimasi Aersilan, Yue Gao, Kenichi Sato, Itoga Sakae, Takayuki Ishige, Motoi Nishimura, Kazuyuki Matsushita, Mamoru Satoh, Fumio Nomura, Satoshi Kuwabara, Tomoaki Tanaka   +19 more
doaj   +1 more source

8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects

Brazilian Journal of Pharmaceutical Sciences, 2020
Parkinson’s disease is a common neurodegenerative disorder. In this study, the monoamine oxidase inhibitory activity and potential anti-parkinsonian effects of 8-propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one (FCS303), a new synthetic coumarin, were ...
María del Pilar Olaya, Nadezdha Esperanza Vergel, Jose Luis López, Dolores Viña, Mario Francisco Guerrero   +4 more
doaj   +1 more source

Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity [PDF]

Journal of Neural Transmission, 2013
ISSN:1435 ...
Bartl, Jasmin, Müller, Thomas, Grünblatt, Edna, Gerlach, Manfred, Riederer, Peter   +4 more
openaire   +5 more sources

Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models

Nature Communications, 2023
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis.
Luis Filipe Costa-Machado, Esther Garcia-Dominguez, Rebecca L. McIntyre, Jose Luis Lopez-Aceituno, Álvaro Ballesteros-Gonzalez, Andrea Tapia-Gonzalez, David Fabregat-Safont, Tobias Eisenberg, Jesús Gomez, Adrian Plaza, Aranzazu Sierra-Ramirez, Manuel Perez, David Villanueva-Bermejo, Tiziana Fornari, María Isabel Loza, Gonzalo Herradon, Sebastian J. Hofer, Christoph Magnes, Frank Madeo, Janet S. Duerr, Oscar J. Pozo, Maximo-Ibo Galindo, Isabel del Pino, Riekelt H. Houtkooper, Diego Megias, Jose Viña, Mari Carmen Gomez-Cabrera, Pablo J. Fernandez-Marcos   +27 more
doaj   +1 more source

4-Phenethyl-1-Propargylpiperidine-Derived Dual Inhibitors of Butyrylcholinesterase and Monoamine Oxidase B

Molecules, 2021
The multi-target-directed ligands (MTDLs) strategy is encouraged for the development of novel modulators targeting multiple pathways in the neurodegenerative cascade typical for Alzheimer’s disease (AD). Based on the structure of an in-house irreversible
Tjaša Mazej, Damijan Knez, Anže Meden, Stanislav Gobec, Matej Sova   +4 more
doaj   +1 more source

18F-SMBT-1: A Selective and Reversible PET Tracer for Monoamine Oxidase-B Imaging

Journal of Nuclear Medicine, 2020
Reactive astrocytes play a key role in the pathogenesis of various neurodegenerative diseases. Monoamine oxidase-B (MAO-B) is one of the promising targets for the imaging of astrogliosis in the human brain. A novel selective and reversible MAO-B tracer, (
R. Harada, Y. Hayakawa, M. Ezura, P. Lerdsirisuk, Yiqing Du, Y. Ishikawa, R. Iwata, M. Shidahara, Aiko Ishiki, A. Kikuchi, H. Arai, Y. Kudo, K. Yanai, S. Furumoto, N. Okamura   +14 more
semanticscholar   +1 more source

Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin versus trans-6-Styrylcoumarin

Molecules, 2022
Monoamine oxidases (MAOs) are attractive targets in drug design. The inhibition of one of the isoforms (A or B) is responsible for modulating the levels of different neurotransmitters in the central nervous system, as well as the production of reactive ...
Marco Mellado, César González, Jaime Mella, Luis F. Aguilar, Ismail Celik, Fernanda Borges, Eugenio Uriarte, Giovanna Delogu, Dolores Viña, Maria J. Matos   +9 more
doaj   +1 more source

Monoamine Oxidase B in Renal Cell Carcinoma [PDF]

Medical Science Monitor, 2018
BACKGROUND Studies on monoamine oxidase B (MAO-B) expression in renal cell carcinoma (RCC) are lacking. This study focused on the immunohistochemical evaluation of MAO-B in RCC. MATERIAL AND METHODS Sixty-three RCC samples were compared on basic clinical and histopathological parameters, including histopathological type and tumor grade.
Hodorová, Ingrid, Rybárová, Silvia, Solár, Peter, Benický, Marián, Rybár, Dušan, Kováčová, Zuzana, Mihalik, Jozef   +6 more
openaire   +2 more sources

Platelet monoamine oxidase activity in alcoholics with and without a family history of alcoholism [PDF]

, 2000
A number of studies point at platelet monoamine oxidase (MAO) activity being reduced in alcoholics with a family history of drinking, this being a possible vulnerability marker for alcoholism.
Benda, Ellen, Bondy, Brigitta, Hegerl, Ulrich, Möller, Hans-Jürgen, Preuss, Ulrich W., Soyka, Michael   +5 more
core   +1 more source

Site-specific expression of amine oxidases in breast cancer metastases

Tumor Biology, 2018
We aimed to evaluate the expression of amine oxidase-related proteins in metastatic breast cancer tissue and determine its clinical implication. A tissue microarray was constructed from a total of 126 metastatic breast tumors (31 bone metastases (24.6%),
Yoon Jin Cha, Woo Hee Jung, Ja Seung Koo
doaj   +1 more source