Results 31 to 40 of about 112,050 (329)

G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. [PDF]

, 2017
G protein-coupled receptors (GPCRs) regulate many animal behaviors. GPCR signaling is mediated by agonist-promoted interactions of GPCRs with heterotrimeric G proteins, GPCR kinases (GRKs), and arrestins.
Aryal, Dipendra K., Benovic, Jeffrey L., Luo, Jiansong, Nass, Richard, Wang, Jianjun, Wetsel, William C.   +5 more
core   +2 more sources

Coumarin analogue 3-methyl-7H-furo[3,2-g] chromen-7-one as a possible antiparkinsonian agent

Biomédica: revista del Instituto Nacional de Salud, 2019
Introduction: Parkinson’s disease is the second most common neurodegenerative disease. Monoamine oxidase B inhibitors are used in the treatment of this disease concomitantly with levodopa or as monotherapy.
María del Pilar Olaya, Nadezdha Esperanza Vergel, José Luis López, María Dolores Viña, Mario Francisco Guerrero   +4 more
doaj   +1 more source

Functional and Biogenetical Heterogeneity of the Inner Membrane of Rat-Liver Mitochondria [PDF]

, 1971
Rat liver mitochondria were fragmented by a combined technique of swelling, shrinking, and sonication. Fragments of inner membrane were separated by density gradient centrifugation.
Allmann D. W., Ashwell M., Beattie D. S., Beattie D. S., Brunner G., Burstone M. S., Davis K. A., Delbruck A., Fiske C. H., Folch J., Gear A. R. L., Gear A. R. L., Gear A. R. L., Gelder B. F., Gotterer G. S., Hasegawa E., Hawley E. S., Johnson A. B., Klingenberg M., Kuntzel H., Labbe R. F., Lentz P. E., Neupert W., Neupert W., Novikoff A. B., Ohnishi K., Omura T., Parsons D. F., Parsons D. F., Pette D., Pollak J. K., Pullmann M. E., Raw J., Raw J., Reith A., Schneider W. C., Schuel H., Schumacher H.-H., Sebald W., Sebald W., Seligman A. M., Sies H., Sottocasa G. L., Stoffel W., Strecker H. J., Swick R. W., Szarkowska L., Tabor C. W., Tol A., Vazquez J. J., Yonetani T.   +50 more
core   +1 more source

Pathological changes in platelet histamine oxidases in atopic eczema

Mediators of Inflammation, 1993
Increased plasma histamine levels were associated with significantly lowered diamine and type B monoamine oxidase activities in platelet-rich plasma of atopic eczema (AE) patients.
Reinhold Kiehl, Gruia Ionescu
doaj   +1 more source

Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity [PDF]

, 2019
A series of benzo[b]thiophen-3-ols were synthesised and investigated as potential human monoamine oxidase (hMAO) inhibitors in vitro as well as ex vivo in rat cortex synaptosomes by means of evaluation of 3,4-dihydroxyphenylacetic acid/dopamine (DOPAC/DA)
Alcaro, Stefano, Bagetta, Donatella, Carradori, Simone, Chimenti, Paola, Ferrante, Claudio, Guglielmi, Paolo, Leone, Sheila, Ortuso, Francesco, Petzer, Anél, Petzer, Jacobus P, Recinella, Lucia, Rotondi, Giulia, Secci, Daniela, Zengin, Gokhan   +13 more
core   +1 more source

Computer-aided approach for the identification of lead molecules as the inhibitors of cholinesterase’s and monoamine oxidases: Novel target for the treatment of Alzheimer disease [PDF]

Journal of the Serbian Chemical Society
Molecular docking is a promising and reliable technology for the purpose of discovering lead compounds via virtual screening. In addition to allowing for the testing of a large number of compounds, it also allows for the determination of how the selected
Ejaz Syeda Abida, Aziz Mubashir, Fayyaz Ammara, Wani Tanveer A., Zargar Seema   +4 more
doaj   +1 more source

Development and butyrylcholinesterase/monoamine oxidase inhibition potential of PVA-Berberis lycium nanofibers

Green Processing and Synthesis, 2022
The aim of this study was to evaluate the potential inhibitory effect of montmorillonite (MMT)-reinforced, glutaraldehyde-crosslinked PVA (polyvinyl alcohol) nanofibers loaded with root extract of Berberis lycium on monoamine oxidase A and B (MAO A and B)
Ibrahim Nihal Abdalla, Kaleem Saba, Khan Abida Kalsoom, Murtaza Ghulam   +3 more
doaj   +1 more source

Monoamine Oxidase B Total Distribution Volume in the Prefrontal Cortex of Major Depressive Disorder: An [11C]SL25.1188 Positron Emission Tomography Study.

JAMA psychiatry, 2019
Importance Monoamine oxidase B (MAO-B) is an important, high-density enzyme in the brain that generates oxidative stress by hydrogen peroxide production, alters mitochondrial function, and metabolizes nonserotonergic monoamines.
S. Moriguchi, Alan A. Wilson, L. Miler, P. Rusjan, N. Vasdev, S. Kish, G. Rajkowska, Junming Wang, M. Bagby, R. Mizrahi, Ben Varughese, S. Houle, J. Meyer   +12 more
semanticscholar   +1 more source

Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazoles [PDF]

, 2019
New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B.
Carradori, Simone, Chimenti, Paola, Cirilli, Roberto, Guglielmi, Paolo, Petzer, Anél, Petzer, Jacobus P., Poli, Giulio, Rotondi, Giulia, Secci, Daniela   +8 more
core   +2 more sources

Monoamine Oxidase Inhibitory Constituents of Propolis: Kinetics and Mechanism of Inhibition of Recombinant Human MAO-A and MAO-B

Molecules, 2014
Propolis is the resinous material that bees gather from leaf buds, flowers and vegetables. Propolis extracts contain constituents with a broad spectra of pharmacological properties and are important ingredients of popular dietary supplements.
Narayan D. Chaurasiya, Mohamed A. Ibrahim, Ilias Muhammad, Larry A. Walker, Babu L. Tekwani   +4 more
doaj   +1 more source