Results 91 to 100 of about 9,063 (256)

Considerations for Initiation and Maintenance of Foslevodopa/Foscarbidopa for Advanced Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background As Parkinson's disease (PD) progresses, motor fluctuations become increasingly difficult to manage with oral medications. Foslevodopa/foscarbidopa (LDp/CDp), delivered as a continuous 24‐h/day subcutaneous infusion, offers continuous levodopa delivery and stable plasma levodopa levels that reduce motor fluctuations. LDp/CDp has been
K. Ray Chaudhuri, Bruno Bergmans, Eric Freire‐Alvarez, Lucie Hopes, Drew S. Kern, Robert S. Kirsner, Giulia Lazzeri, Pedro Mendes‐Bastos, Noriko Nishikawa, Per Odin, Karolina Poplawska‐Domaszewicz, Rajesh Pahwa, Yuval Ramot, Klaus Seppi, Tobias Warnecke, Robert Wiggins, Megha B. Shah, Pavnit Kukreja, Bjoern Fritz, Koray Onuk, Stuart H. Isaacson   +20 more
wiley   +1 more source

Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice [PDF]

, 2013
Background The next big challenge in human genetics is understanding the 98% of the genome that comprises non-coding DNA. Hidden in this DNA are sequences critical for gene regulation, and new experimental strategies are needed to understand the ...
Andrea J Korecki, Daniel Goldowitz, Elizabeth M Simpson, Elodie Portales-Casamar, Gary Wilson, Jean-François Schmouth, Kathleen G Banks, Lisa Borretta, Lisa Dreolini, Mahsa Amirabbasi, Mauro Castellarin, Robert A Holt, Russell J Bonaguro, Simone C McInerny, Steven JM Jones, Stéphanie Laprise, Wyeth W Wasserman   +16 more
core   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent

Antioxidants, 2020
Urolithin A is a metabolite generated from ellagic acid and ellagitannins by the intestinal microbiota after consumption of fruits such as pomegranates or strawberries.
Guillermo Cásedas, Francisco Les, Carmen Choya-Foces, Martín Hugo, Víctor López   +4 more
doaj   +1 more source

Assessment of enzyme inhibition : a review with examples from the development of monoamine oxidase and cholinesterase inhibitory drugs [PDF]

, 2017
Both authors are grateful for the collaborations on multi-target drugs facilitated by COST Action CM1103 (2011-2015).The actions of many drugs involve enzyme inhibition.
Ramsay, Rona R., Tipton, Keith F.
core   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

Monoamine oxidases contribute to endothelial dysfunction of the vascular access in hemodialysis patients [PDF]

Research and Clinical Medicine, 2016
OBJECTIVES Arteriovenous fistulas (AVF) are the 'lifeline' for patients with terminal end-stage renal disease (ESRD) on chronic hemodialysis. AVF maturation failure is a poorly understood process, and is partially caused by endothelial dysfunction ...
Diana Utu, Adrian Sturza, Stelian Pantea , Danina Muntean   +3 more
doaj  

Development of novel fluorine-18 labeled PET radioligands for monoamine oxidase B (MAO-B) [PDF]

, 2013
Monoamine oxidases (MAO-A and MAO-B) are important enzymes regulating the levels of monoaminergic neurotransmitters. Selectiv e and irreversible MAO-B inhibitors such as L -deprenyl and rasagiline are clinically used for the t reatment of ...
Nag, Sangram
core   +2 more sources

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source

The upstream Variable Number Tandem Repeat polymorphism of the monoamine oxidase type A gene influences trigeminal pain-related evoked responses [PDF]

, 2014
Monoamines have an important role in neural plasticity, a key factor in cortical pain processing that promotes changes in neuronal network connectivity.
Barone, Y, Coppola, G, Daverio, A, Di Lorenzo, C, Di Lorenzo, G, Giannoudas, I, Grieco, G, Nicoletti, F, Niolu, C, Pascale, E, Pasqualetti, P, Pierelli, F, Santorelli, F, Seri, S, Siracusano, A   +14 more
core   +1 more source