Results 111 to 120 of about 4,684 (142)
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Current Pharmaceutical Biotechnology, 2018
Drug-induced myopathy is a serious side effect that often requires removal of a medication from a drug regimen. For most drugs, the underlying mechanism of drug-induced myopathy remains unclear. Monocarboxylate transporters (MCTs) mediate L-lactic acid transport, and inhibition of MCTs may potentially lead to perturbation of L-lactic acid accumulation ...
Yat H, Leung +4 more
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Drug-induced myopathy is a serious side effect that often requires removal of a medication from a drug regimen. For most drugs, the underlying mechanism of drug-induced myopathy remains unclear. Monocarboxylate transporters (MCTs) mediate L-lactic acid transport, and inhibition of MCTs may potentially lead to perturbation of L-lactic acid accumulation ...
Yat H, Leung +4 more
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Transport of lactic acid in Kluyveromyces marxianus: Evidence for a monocarboxylate uniport
Yeast, 1991AbstractLactic acid‐grown cells of a strain of Kluyveromyces marxianus transported D‐and L‐lactic acid by a saturable mechanism that was partially inducible and subject to glucose repression, with the following kinetic parameters at pH 5·4: Vmax = 1·00 (±0·13) mmol h−1 per g dry weight and Ks = 0·42 (±0·08) mM.
A, Fonseca +2 more
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Comprehensive Physiology, 2013
Abstract Monocarboxylates such as lactate, pyruvate, and the ketone bodies play major roles in metabolism and must be transported across both the plasma membrane and mitochondrial inner membrane. A family of five proton‐linked MonoCarboxylate Transporters (MCTs) is involved in the former and the mitochondrial ...
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Abstract Monocarboxylates such as lactate, pyruvate, and the ketone bodies play major roles in metabolism and must be transported across both the plasma membrane and mitochondrial inner membrane. A family of five proton‐linked MonoCarboxylate Transporters (MCTs) is involved in the former and the mitochondrial ...
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Drug Metabolism and Disposition, 2007
Monocarboxylate transporter 1 (MCT1) is an important determinant of the renal transport of the drug of abuse, gamma-hydroxybutyric acid (GHB). The objective of this study was to investigate the role of MCT2 and MCT4, present in tissues including intestine, kidney, skeletal muscle, and brain, in the membrane transport of GHB and the MCT substrate l ...
Qi, Wang, Marilyn E, Morris
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Monocarboxylate transporter 1 (MCT1) is an important determinant of the renal transport of the drug of abuse, gamma-hydroxybutyric acid (GHB). The objective of this study was to investigate the role of MCT2 and MCT4, present in tissues including intestine, kidney, skeletal muscle, and brain, in the membrane transport of GHB and the MCT substrate l ...
Qi, Wang, Marilyn E, Morris
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Transport of Hexoses and Monocarboxylic Acids
1983Although the dependence of the mammalian brain, under normal conditions, on a regular supply of glucose from the bloodstream has been acknowledged for 50 years or more, ways by which glucose passes to the brain and how it travels within the brain were ignored until relatively recently.
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Role of monocarboxylic acid transport in intracellular pH regulation of isolated proximal cells
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1988Isolated proximal cells were prepared from rabbit kidney cortex by mechanical dissociation. The intracytoplasmic pH (pHi) was measured in HCO3(-)-free media (external pH (pHe), 7.3) using the fluorescent dye 2,7-biscarboxyethyl-5,6-carboxyfluorescein (BCECF). Cells were acid-loaded by the nigericin technique. Addition of 70 mM Na+ to the cells caused a
Bidet, Michel +3 more
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Monocarboxylate transport inhibition alters retinal function and cellular amino acid levels
European Journal of Neuroscience, 2004AbstractWe assessed the effect of the in vivo application of monocarboxylate transport inhibitors on retinal function and amino acid immunocytochemistry. We wanted to determine the impact that altered aerobic metabolite availability has on retinal function and the characteristics of amino acid shunting into metabolic pools.
Bang V, Bui +3 more
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Pfl�gers Archiv European Journal of Physiology, 2004
The monocarboxylate cotransporter (MCT) family now comprises 14 members, of which only the first four (MCT1-MCT4) have been demonstrated experimentally to catalyse the proton-linked transport of metabolically important monocarboxylates such as lactate, pyruvate and ketone bodies.
Halestrap, AP, Meredith, D
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The monocarboxylate cotransporter (MCT) family now comprises 14 members, of which only the first four (MCT1-MCT4) have been demonstrated experimentally to catalyse the proton-linked transport of metabolically important monocarboxylates such as lactate, pyruvate and ketone bodies.
Halestrap, AP, Meredith, D
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Stereoselective and Carrier-Mediated Transport of Monocarboxylic Acids Across Caco-2 Cells
Pharmaceutical Research, 1996To characterize the transport mechanism of monocarboxylic acids across intestinal epithelial cells by examining the stereoselectivity of the transcellular transport of several chiral monocarboxylic acids.The transport of monocarboxylic acids was examined using monolayers of human adenocarcinoma cell line, Caco-2 cells.The permeability of L-[14C]lactic ...
T, Ogihara +4 more
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Monocarboxylate Transporter Mediates Uptake of Lovastatin Acid in Rat Cultured Mesangial Cells
Journal of Pharmaceutical Sciences, 2002To clarify the uptake mechanism(s) for statins, we examined whether monocarboxylate transporter (MCT) contributed to the uptake of lovastatin acid by rat cultured mesangial cells. Expression of mRNAs for MCT1, 2, and 4 was confirmed in mesangial cells. The uptake of lovastatin acid by mesangial cells increased with decreasing extracellular pH.
Kazuki, Nagasawa +8 more
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