Results 121 to 130 of about 4,684 (142)
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Carbohydrate Polymers, 2015
The purpose of this study was to study the transport of monocarboxylic acids in chitosan films, since this is important for understanding and predicting the drying kinetics of chitosan from aqueous solutions. Despite the wealth of data on chitosan films prepared from aqueous monocarboxylic acid solutions, this transport has not been reported.
Fei, Chen +4 more
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The purpose of this study was to study the transport of monocarboxylic acids in chitosan films, since this is important for understanding and predicting the drying kinetics of chitosan from aqueous solutions. Despite the wealth of data on chitosan films prepared from aqueous monocarboxylic acid solutions, this transport has not been reported.
Fei, Chen +4 more
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Inhibition of Monocarboxylate Transporter-Mediated Absorption of Valproic Acid by Gegen-Qinlian-Tang
The American Journal of Chinese Medicine, 2013Valproic acid (VPA), an anti-epileptic drug with a narrow therapeutic index, is a substrate of the monocarboxylate transporter (MCT). In this study, we investigated the effect of Gegen-Qinlian-Tang (GQT), a Chinese Medicine prescription containing Puerariae Radix (PR), Scutellariae Radix (SR), Coptidis Rhizoma (CR) and Glycyrrhizae Radix (GR), on the ...
Hsueh-Jung, Liu +4 more
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Drug Metabolism and Disposition, 2002
Neotrofin (AIT-082; leteprinim potassium) is transported out of brain by a saturable mechanism and in this study the mechanisms mediating this efflux were evaluated. Intracerebroventricular coadministration of [(14)C]Neotrofin with verapamil, a P-glycoprotein inhibitor, probenecid, an organic anion transporter inhibitor, 3-[[3-[2-(7-chloroquinolin-2-yl)
Rongzi, Yan, Eve M, Taylor
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Neotrofin (AIT-082; leteprinim potassium) is transported out of brain by a saturable mechanism and in this study the mechanisms mediating this efflux were evaluated. Intracerebroventricular coadministration of [(14)C]Neotrofin with verapamil, a P-glycoprotein inhibitor, probenecid, an organic anion transporter inhibitor, 3-[[3-[2-(7-chloroquinolin-2-yl)
Rongzi, Yan, Eve M, Taylor
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Drug Metabolism and Pharmacokinetics, 2019
Using X. laevis oocyte expression system, we investigated whether human Na+-coupled monocarboxylate transporter 1 (SLC5A8, hSMCT1) is involved in 2,4-dichlorophenoxyacetate (2,4-D) uptake by the renal tubular epithelial cells. 2,4-D is a herbicide that causes nephrotoxicity. Heterologous expression of hSMCT1 in X.
Kazuaki Sugio +7 more
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Using X. laevis oocyte expression system, we investigated whether human Na+-coupled monocarboxylate transporter 1 (SLC5A8, hSMCT1) is involved in 2,4-dichlorophenoxyacetate (2,4-D) uptake by the renal tubular epithelial cells. 2,4-D is a herbicide that causes nephrotoxicity. Heterologous expression of hSMCT1 in X.
Kazuaki Sugio +7 more
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Targeting monocarboxylate transporters to reverse lactic acid-driven immunosuppression
Intra-tumoral lactate accumulation and acidosis impair T cell function and anti-tumor immunity. Interestingly, expression of the lactate transporter monocarboxylate transporter (MCT) 4, but not MCT1, is prognostic for the survival of rectal cancer patients, indicating that single MCT4 blockade might be a promising strategy to overcome glycolysis ...openaire +2 more sources
Volatile fatty acids production in ruminants and the role of monocarboxylate transporters: A review
2013Monocarboxylates commonly referred to as short-chain fatty acids (SCFAs) are metabolized to different extents by the epithelium of the gastrointestinal tract. They are absorbed along different segments of the gastrointestinal tract and constitute a significant amount of energy in ruminants.
Aluwong, T, Kobo, PI, Abdullahi, A
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