World Journal of Otorhinolaryngology-Head and Neck Surgery, 2022 Background PD‐1 and PD‐L1 inhibitors have emerged as promising treatments for patients with head and neck squamous cell carcinoma (HNSCC). Methods Systematic review and meta‐analysis of PD‐1 and PD‐L1 inhibitors in HNSCC.
Dylan A. Levy +9 more
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Recent Progress in the Discovery and Development of Monoclonal Antibodies against Viral Infections
Biomedicines, 2022 Monoclonal antibodies (mAbs), the new revolutionary class of medications, are fast becoming tools against various diseases thanks to a unique structure and function that allow them to bind highly specific targets or receptors.
Pardis Mokhtary +4 more
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X-Linked Hypophosphatemic Rickets: A Pediatric Case Report [PDF]
Revista Portuguesa de Nefrologia e Hipertensão, 2022 X-linked hypophosphatemic rickets is a monogenic disease, characterized by hyperphosphaturia and hypophosphatemia. Due to its rarity and wide phenotypic variability, a diagnostic delay is common in X-linked hypophosphatemic rickets.
Isabel Rodrigues Leal Moitinho de Almeida +3 more
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Differential binding patterns of anti-sulfatide antibodies to glial membranes [PDF]
, 2018 Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may ...
Barrie, Jennifer A. +8 more
core +1 more source
Human monoclonal antibodies and monoclonal antibody multispecificity [PDF]
British Journal of Cancer, 1987 The majority of human anti-tumour monoclonal antibodies (Mabs) isolated to date have been disappointing. Firstly, they react or cross react with intracellular cytoskeletal proteins or nuclear antigens and therefore are of limited value as blood borne agents.
A M, Campbell, P, Whitford, R E, Leake
openaire +2 more sources
Frontiers in Immunology, 2021 Monoclonal antibodies (mAbs) have been a valuable tool to elucidate several biological processes, such as stem cell differentiation and cancer, and contributed to virtually all areas of biomedical sciences.
Marina de Lima Fontes +7 more
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Rat Monoclonal Antibodies Specific for LST1 Proteins [PDF]
, 2009 The LST1 gene is located in the human MHC class III region and encodes transmembrane and soluble isoforms that have been suggested to play a role in the regulation of the immune response and are associated with inflammatory diseases such as rheumatoid ...
Kremmer, Elisabeth +4 more
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Emerging antibody-based products for infectious diseases: Planning for metric ton manufacturing
Human Vaccines & Immunotherapeutics, 2022 This review focuses on the emerging monoclonal antibody market for infectious diseases and the metric ton scale manufacturing requirements to meet global demand.
Kevin J Whaley, Larry Zeitlin
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Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]
, 2005 Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Huss, R. +4 more
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Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis [PDF]
, 1992 Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient
Bassendine +49 more
core +1 more source