Results 21 to 30 of about 1,828,522 (388)
Proliferative activity of myeloma cells determined by Ki-67 antibody: Biological and clinical significance [PDF]
Vojnosanitetski Pregled, 2005 In this study we analyzed proliferative activity of myeloma cells and a possible correlation with selected clinical data, histological features and survival in 59 patients with newly diagnosed multiple myeloma (27 females and 32 males, mean age 62 years).
Marković Olivera +7 more
doaj +1 more source
Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq. [PDF]
, 2016 BackgroundThe robustness of ChIP-seq datasets is highly dependent upon the antibodies used. Currently, polyclonal antibodies are the standard despite several limitations: They are non-renewable, vary in performance between lots and need to be validated ...
Busby, Michele +11 more
core +1 more source
Immunogenicity Risk Assessment of Spontaneously Occurring Therapeutic Monoclonal Antibody Aggregates
Frontiers in Immunology, 2022 Aggregates of therapeutic proteins have been associated with increased immunogenicity in pre-clinical models as well as in human patients. Recent studies to understand aggregates and their immunogenicity risks use artificial stress methods to induce high
Michael D. Swanson +4 more
doaj +1 more source
Monoclonal Antibodies in Cancer Therapy
Antibodies, 2020 Monoclonal antibody-based immunotherapy is now considered to be a main component of cancer therapy, alongside surgery, radiation, and chemotherapy. Monoclonal antibodies possess a diverse set of clinically relevant mechanisms of action.
D. Zahavi, L. Weiner
semanticscholar +1 more source
Clinical and Translational Medicine, 2022 Background As the field of stem cell therapy advances, it is important to develop reliable methods to overcome host immune responses in animal models. This ensures survival of transplanted human stem cell grafts and enables predictive efficacy testing ...
Lisa M. McGinley +9 more
doaj +1 more source
Long-term prophylaxis of hereditary angioedema [PDF]
Liječnički vjesnik, 2022 Hereditary angioedema (HAE) is a rare inherited disease characterized by recurrent attacks of painful swelling of the subcutaneous and submucosal tissues.
Dijana Perković +8 more
doaj +1 more source
Advances in acute and preventive treatment of migraine
Chinese Journal of Contemporary Neurology and Neurosurgery, 2022 Migraine is a common and often disabling neurologic disease, its high prevalence and disability significantly impact on patients and relatives, contributing to heavy social and economic burden.
LIN Xiaoxue +3 more
doaj +1 more source
Human monoclonal antibodies and monoclonal antibody multispecificity [PDF]
British Journal of Cancer, 1987 The majority of human anti-tumour monoclonal antibodies (Mabs) isolated to date have been disappointing. Firstly, they react or cross react with intracellular cytoskeletal proteins or nuclear antigens and therefore are of limited value as blood borne agents.
AM Campbell, P Whitford, RE Leake
openaire +2 more sources
A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19
New England Journal of Medicine, 2020 Background LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19).
J. Lundgren +45 more
semanticscholar +1 more source
Use of OKT3 with ciclosporin and steroids for reversal of acute kidney and liver allograft rejection [PDF]
, 1987 OKT3 monoclonal antibody therapy was added to preexisting baseline immunosuppressive treatment with ciclosporin and steroids to treat rejection in 52 recipients of cadaveric livers and 10 recipients of cadaveric kidneys.
Demetris, AJ, Fung, JJ, Porter, KA
core +1 more source