Advanced Healthcare Materials, EarlyView.Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner +5 more
wiley +1 more source
Leveraging Large Language Models to Predict Antibody Biological Activity Against Influenza A Hemagglutinin [PDF]
arXivMonoclonal antibodies (mAbs) represent one of the most prevalent FDA-approved modalities for treating autoimmune diseases, infectious diseases, and cancers. However, discovery and development of therapeutic antibodies remains a time-consuming and expensive process. Recent advancements in machine learning (ML) and artificial intelligence (AI) have shown
arxiv
The Case of a 67‐Year‐Old Man With Memory Difficulties and Altered Sleep
Annals of Clinical and Translational Neurology, EarlyView.
Wesley Peng, Borna Bonakdarpour
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Melanoma cell spheroid engraftment is optimized in the chicken chorioallantoic membrane overcoming the complexity of other in vivo models. Using this model, greater penetration of cerium oxide nanoparticles (nanoceria) functionalized with heparin in spheroids is observed via enhancement of vascularization than nanoceria alone.
Lu Fu +5 more
wiley +1 more source
Monoclonal antibodies specific for Shigella flexneri lipopolysaccharides: clones binding to type IV, V, and VI antigens, group 3,4 antigen, and an epitope common to all Shigella flexneri and Shigella dysenteriae type 1 stains [PDF]
, 1987 Nils Carlin, Alf A. Lindberg
openalex +1 more source
Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response
Advanced Healthcare Materials, EarlyView.In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim +11 more
wiley +1 more source
Mutation N856K in spike reduces fusogenicity and infectivity of Omicron BA.1
Signal Transduction and Targeted Therapy, 2023 Chunyun Sun +9 more
doaj +1 more source
Hyperbox Mixture Regression for Process Performance Prediction in Antibody Production [PDF]
arXivThis paper addresses the challenges of predicting bioprocess performance, particularly in monoclonal antibody (mAb) production, where conventional statistical methods often fall short due to time-series data's complexity and high dimensionality.
arxiv
Characterization of a monoclonal antibody to the group antigen ofChlamydiaspp. and its use for antigen detection by reverse passive haemagglutination and indirect immunofluorescence [PDF]
, 1983 Margaret J. Thornley +6 more
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Advanced Healthcare Materials, EarlyView.High glucose‐ and acid‐responsive hydrogel with dynamic covalent bond solubilized with flavonoids (Gel‐Flavonoids) is designed for diabetic wound healing. The Gel‐Flavonoids adapt to irregular wound shapes and release antioxidants in high‐glucose environments, effectively reducing reactive oxygen species.
Qiang Zeng +9 more
wiley +1 more source