Results 71 to 80 of about 1,325,739 (304)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Monoclonal antibodies against human astrocytomas and their reactivity pattern [PDF]

, 1987
The establishment of hybridomas after fusion of X63-Ag8.653 mouse myeloma cells and splenocytes from mice hyperimmunized against human astrocytomas is presented. The animals were primed with 5 × 106 chemically modified uncultured or cultured glioma cells.
Eisenmenger, Wolfgang, Schmidberger, F., Funke, I., Kurrle, R., Martin, B., Stavrou, D., Bise, K., Stocker, U., Keiditsch, E.   +8 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Generation and characterization of rat and mouse monoclonal antibodies specific for MeCP2 and their use in X-inactivation studies [PDF]

, 2011
Methyl CpG binding protein 2 (MeCP2) binds DNA, and has a preference for methylated CpGs and, hence, in cells, it accumulates in heterochromatin. Even though it is expressed ubiquitously MeCP2 is particularly important during neuronal maturation. This is
Rottach Andrea, Jost, K.L., Becker, Annette, Andrea Rottach, Leonhardt, Heinrich, Becker, A., Manel Esteller, Esteller, Manel, K Laurence Jost, Wolf, P., Jost K. Laurence, Wolf, Patricia, Cardoso, M. Cristina, Leonhardt Heinrich, Paolo Petazzi, Huertas Dori, Annette Becker, Cardoso M. Cristina, Patricia Wolf, Milden Manuela, Wolf Patricia, Esteller Manel, K. Laurence Jost, Bertulat Bianca, Dori Huertas, Milden, M., Huertas, D., Juan Sandoval, Bianca Bertulat, Sandoval, Juan, M. Cristina Cardoso, Bertulat, B., Kremmer Elisabeth, Petazzi Paolo, Milden, Manuela, Huertas, Dori, Becker Annette, Rottach, A., Jost, K. Laurence, Sandoval, J., Esteller, M., Kremmer, E., Manuela Milden, Kremmer, Elisabeth, Cardoso, M.C., Heinrich Leonhardt, Sandoval Juan, Petazzi, Paolo, Petazzi, P., M Cristina Cardoso, Bertulat, Bianca, Rottach, Andrea, Elisabeth Kremmer, Leonhardt, H.   +53 more
core   +2 more sources

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Studies on the production, characterisation and applications of monoclonal antibodies and antibody-based conjugates [PDF]

, 1994
The work described in this thesis involved the production of antibodies to several defined antigens and the chemical synthesis of bispecific antibodies. Monoclonal antibodies against glial fibrillary acidic protein (anti-GFAP), and against a GFAP-like
Cahill, Dolores J.
core   +2 more sources

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Effects of Different Drying Methods on the Quality of Armillaria mellea Based on Physicochemical Properties, Nutritional Components, and Volatile Flavor [PDF]

Shipin Kexue
To systematically evaluate the processing adaptability of Armillaria mellea, this study compared the effects of four drying methods: natural drying (ND), hot air drying (HD), microwave drying (MD), and vacuum freeze drying (VFD) on its physicochemical ...
YUAN Yongxu, LI Na, WANG Yiting, LI Ming, PEI Shichun, CUI Yanyan
doaj   +1 more source