Results 101 to 110 of about 10,254 (215)

Targeting Ikaros and Aiolos: Next‐Generation Cereblon E3 Ligase Modulators in MM

European Journal of Haematology, Volume 116, Issue 6, Page 697-708, June 2026.
The graphical abstract illustrates the mechanism of action of cereblon E3 ligase modulators (CELMoDs) in multiple myeloma, highlighting cereblon‐mediated degradation of IKZF1 and IKZF3. Compared with classical immunomodulatory drugs (IMiDs), CELMoDs induce deeper IKZF1/3 depletion, leading to more pronounced suppression of the IRF4–MYC survival axis ...
Maria Eugenia Alvaro, Enrica Antonia Martino, Santino Caserta, Mamdouh Skafi, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Insulin Signalling‐Inducible IFITM1 Promotes Multiple Myeloma Progression and Bortezomib Resistance

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Insulin substantially promotes the growth of malignant cells that overexpress the insulin receptor (INSR), and insulin excess has been recognised as a cancer‐promoting factor in patients. Interferon‐induced transmembrane protein 1 (IFITM1) is also overexpressed in various cancers.
Ji‐Young Lim, Yeojin Kim, Sung‐Soo Park, Jungyeon Lee, Chang‐Ki Min   +4 more
wiley   +1 more source

Related Article from Prevention of Progression in Monoclonal Gammopathy of Undetermined Significance

, 2009
Related Article from Prevention of Progression in Monoclonal Gammopathy of Undetermined ...
S. Vincent Rajkumar (7417883)
core   +1 more source

Autonomic Nervous System Phenotyping Across Chronic Demyelinating Peripheral Neuropathies: A Comparative Study

Journal of the Peripheral Nervous System, Volume 31, Issue 2, June 2026.
ABSTRACT Background and Aims This study aimed to systematically phenotype autonomic nervous system (ANS) involvement in patients with chronic inflammatory demyelinating polyneuropathy (CIDP), monoclonal gammopathy of undetermined significance‐associated neuropathy (MGUS‐PNP), Charcot–Marie–Tooth disease Type 1A (CMT1A), and hereditary neuropathy with ...
Bogdan Bjelica, Teodora Todorovic, Ivo Bozovic, Aleksa Palibrk, Vladimir Jankovic, Ivana Basta, Stojan Peric   +6 more
wiley   +1 more source

Survival in monoclonal gammopathy of undetermined significance and Waldenström macroglobulinemia

, 2013
Monoclonal gammopathy of undetermined significance (MGUS) of IgM type is the strongest risk factor for the development of Waldenström macroglobulinemia (WM).
Kristinsson, Sigurdur Y, Björkholm, Magnus, Landgren, Ola, Landgren, Carl   +3 more
core   +1 more source

Late Presentation of de Novo Proliferative Glomerulonephritis With Monoclonal IgG Deposits in a Renal Allograft: A Rare Case With an Unusual Clinical Course

Nephrology, Volume 31, Issue 6, June 2026.
ABSTRACT Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a form of monoclonal gammopathy of renal significance (MGRS) in which monoclonal immunoglobulin deposits are found within the glomerulus, without involvement of other renal compartments.
Hayley J. Duxbury, David A. Brown, Adrian Y. S. Lee, Germaine Wong, Fiona Kwok, Seethalakshmi Viswanathan   +5 more
wiley   +1 more source

Polyneuropathy associated with monoclonal gammopathy of undetermined significance

, 2012
The prevalence of polyneuropathy in patients with monoclonal gammopathy of undetermined significance (MGUS) has been reported to be 10-50%. The majority of patients have a chronic, slowly progressive, distal, symmetric and predominantly sensory ...
Abildgaard, Niels, Sindrup, Søren, Kolmos, Eva Brøsted, Schrøder, Henrik Daa; id_orcid, Moth Henriksen, Marie   +4 more
core   +1 more source

Patient With MGRS/PGNMID Without Detection of a Peripheral Clone: Case Report and Literature Review

Case Reports in Hematology
Monoclonal gammopathy of renal significance (MGRS) is a clonal cell proliferative disorder, characterized by the production of monoclonal immunoglobulins in patients that do not meet hematological criteria for a specific malignancy.
Agatha Larrazábal, Ana Ávila-Rodriguez, Matías Sánchez   +2 more
doaj   +1 more source

Aspergillus fumigatus scleritis associated with monoclonal gammopathy of undetermined significance.

, 2010
A 68-year-old woman presented with pain in her left eye. Necrosis with calcium plaques was observed on the medial part of the sclera. Aspergillus fumigatus was isolated from the culture of the necrotic area.
Wee, W.R., Heo, J.W., Oh, J.Y., Jo, D.H., Kim, M.K., Lee, J.H.   +5 more
core   +1 more source

My Patient with Monoclonal Gammopathy of Undetermined Significance has a Kidney Problem

, 2017
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition signifying the presence of a B-cell lymphoproliferative disorder. By connotation, it should not meet the definition of multiple myeloma, Waldenström macroglobulinemia,
Nelson Leung
core   +1 more source