Results 81 to 90 of about 145,799,037 (198)

Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease

American Journal of Hematology, Volume 101, Issue 9, Page 2197-2213, September 2026.
ABSTRACT Chronic antigenic stimulation is implicated in the pathogenesis of monoclonal gammopathy and multiple myeloma, yet longitudinal human evidence linking sustained antigen exposure to modifiable clonal plasma cell evolution remains limited. Gaucher disease (GD), caused by biallelic GBA1 pathogenic variants, is characterized by accumulation of ...
Noor Ul Ain, Noffar Bar, Lilu Guo, Katherine Klinger, Punita Gupta, Atta Ur Rahman, Ruhua Yang, Yanhong Deng, Natalia Neparidze, Shiny Nair, Pramod K. Mistry   +10 more
wiley   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, Volume 293, Issue 17, Page 5121-5139, September 2026.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

What is the significance of monoclonal gammopathy of undetermined significance?

, 2018
Monoclonal gammopathy of undetermined significance (MGUS) is characterised by the presence of a monoclonal paraprotein in the blood, without the characteristic end organ damage seen in multiple myeloma.
Catherine Atkin, Atkin, Catherine; id_orcid, Richter, Alex, Sapey, Elizabeth; id_orcid, Alex Richter, Elizabeth Sapey   +5 more
core   +1 more source

Monoclonal gammopathy of undetermined significance and risk of lymphoid and myeloid malignancies: 728 cases followed up to 30 years in Sweden. [PDF]

, 2014
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.In 728 Swedish cases of monoclonal gammopathy of undetermined significance (MGUS), followed up to 30 years (median, 10 years), we estimated ...
Drayson, Mark T., Pfeiffer, RM, Turesson, I, Goldin, Lynn R., Turesson, Ingemar, Kristinsson, Sigurdur Y, Landgren, Ola, Kovalchik, SA, Drayson, MT, Drayson, Mark T, Pfeiffer, Ruth M., Goldin, Lynn R, Pfeiffer, Ruth M, Kovalchik, Stephanie A., Goldin, LR, Kovalchik, Stephanie, Lund University., Kristinsson, Sigurdur Y., Landgren, Carl, Turesson, Ingemar,, Kovalchik, Stephanie A, Kristinsson, SY, Landgren, O   +22 more
core   +2 more sources

Untangling fracture risk in monoclonal gammopathy of undetermined significance: A population‐based cohort study

, 2021
Objective Monoclonal gammopathy of undetermined significance (MGUS) is the asymptomatic precursor of multiple myeloma (MM). Lytic bone lesions and fractures are hallmarks of MM and although there are no lytic lesions in MGUS, it has also been associated ...
Turesson, Ingemar, Aspelund, T, Thor Aspelund, Bjorkholm, Magnus, Thorsteinsdottir, S, Thorsteinsdottir, Sigrun, Turesson, I, Rognvaldsson, Saemundur, Landgren, Ola, Magnus Björkholm, Aspelund, Thor, Kristinsson, Sigurour Yngvi, Ola Landgren, Sigurður Yngvi Kristinsson, Rognvaldsson, S, Bjorkholm, M, Sigrún Thorsteinsdóttir, Sæmundur Rögnvaldsson, Ingemar Turesson, Landgren, Carl, Landgren, O, Kristinsson, SY   +21 more
core   +1 more source

MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival [PDF]

, 2011
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work
Hatton, CSR, Taylor Steve, Taylor, Stephen, Taylor, S, Lawrie Charles H, Saunders, NJ, Steve Taylor, Pezzella Francesco, Saunders Nigel J, Tramonti, D, Lawrie, CH, Wainscoat James S, Kusec, R, Pezzella, F, Tramonti Daniela, Nigel J Saunders, Hatton Christian SR, Chen, XH, Hatton, CS, Charles H Lawrie, Rajko Kušec, Littlewood, T, Erica Ballabio, Deborah Hay, Timothy Littlewood, Chi, J, Jacqueline Boultwood, Boultwood Jacqueline, Kušec Rajko, Jianxiang Chi, Chen Xiao-He, James S Wainscoat, Ballabio, E, Ballabio Erica, Chi Jianxiang, Xiao-He Chen, Littlewood Timothy, Francesco Pezzella, Christian SR Hatton, Wainscoat, JS, Hay Deborah, Pezzella, Francesco, Boultwood, Jacqueline, Hay, D, Boultwood, J, Daniela Tramonti   +45 more
core   +1 more source

Monoclonal gammopathy of significance

, 2018
The presence of a monoclonal protein in the serum and/or urine is a common clinical condition that increases in incidence with age. Although the diagnosis is most often monoclonal gammopathy of undetermined significance (MGUS) there are many conditions ...
Dingli, David
core  

Living kidney donor with monoclonal gammopathy of undetermined significance: Is it a contraindication for kidney donation?

, 2019
Kidney transplantation is the treatment of choice for patients suffering from end-stage renal disease. We report a case of living kidney transplantation in which the donor had monoclonal gammopathy of undetermined significance, a condition having ...
Vinay Rathore, Pankaj Beniwal, Dhananjai Agarwal, Sanjeev Sharma, Vinay Malhotra, Rajesh Jhorawat   +5 more
core   +1 more source

Monoclonal gammopathy of undetermined significance and Waldenström's macroglobulinemia

, 2016
Since the initial identification of patients with monoclonal elevation of gamma globulin and associated clinical symptoms in 1944 by Jan Waldenström, several new insights have been gained using a range of approaches.
Mailankody, Sham, Landgren, Ola, Landgren, Carl   +2 more
core   +1 more source

Related Article from Prevention of Progression in Monoclonal Gammopathy of Undetermined Significance

, 2009
Related Article from Prevention of Progression in Monoclonal Gammopathy of Undetermined ...
S. Vincent Rajkumar (7417883)
core   +1 more source