Results 61 to 70 of about 10,254 (215)

Plasma Elastase Screening in Hematological Disease Reveals Its Potential as a Diagnostic and Prognostic Biomarker in Hematological Malignancies

open access: yesInternational Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Neutrophil‐extracellular traps are net‐like material released by triggered neutrophils and composed of decondensed chromatin linked to nuclear proteins. Elastase, one of the fourth most represented neutrophil‐specific serine proteases stored in azurophil granules of naïve neutrophils, exerts various actions, including degradation ...
Pasqualina Scala   +14 more
wiley   +1 more source

C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report

open access: yesBMC Nephrology, 2018
Background Morbidity associated with monoclonal gammopathy of renal significance is high due to the severe renal lesions and the associated systemic alterations.
Juana Alonso-Titos   +11 more
doaj   +1 more source

Circadian Deregulation in Multiple Myeloma: BMAL1/CLOCK Expression Patterns and Diagnostic Performance

open access: yesInternational Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Circadian clock disruption has emerged as a relevant axis in cancer; however, the expression patterns and diagnostic relevance of BMAL1 and CLOCK in multiple myeloma (MM) remain insufficiently defined. Methods BMAL1 and CLOCK mRNA expression was quantified by RT‐qPCR in bone marrow samples from 46 newly diagnosed MM patients and 13 ...
Hamide Albayrak   +6 more
wiley   +1 more source

Cytogenetic profiles in multiple myeloma and monoclonal gammopathy of undetermined significance: a study in highly purified aberrant plasma cells

open access: yesHaematologica, 2013
Cytogenetic studies in clonal plasma cell disorders have mainly been done in whole bone marrow or CD138+ microbead-enriched plasma cells and suggest that recurrent immunoglobulin heavy chain translocations - e.g.
Martin Schmidt-Hieber   +12 more
doaj   +1 more source

Schnitzler Syndrome as an Autoinflammatory Disease Driven by B‐Cell‐Specific Somatic MYD88 Mutation

open access: yes
Allergy, EarlyView.
Yuyi Zhou   +10 more
wiley   +1 more source

Circulating Tumor Cells in Multiple Myeloma: From Peripheral Clues to Central Insights

open access: yesAmerican Journal of Hematology, Volume 101, Issue 7, Page 1575-1588, July 2026.
CTC offer a minimally invasive widow into systemic myeloma biology, overcoming the sampling bias of bone marrow biopsies. Their prognostic value at diagnosis, potential role in MRD monitoring, and ability to capture clonal evolution highlight them as actionable biomarkers for future precision medicine.
Benjamin Podvin   +3 more
wiley   +1 more source

Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant.

open access: yes, 2012
International audienceMultiple myeloma is the most frequent monoclonal gammopathy to involve the kidney; however, a growing number of kidney diseases associated with other monoclonal gammopathies are being recognized.
Nasr, Samih H   +9 more
core   +1 more source

Quality of Life in Patients With Chronic Inflammatory Demyelinating Polyneuropathy

open access: yesMuscle &Nerve, Volume 74, Issue 1, Page 59-67, July 2026.
ABSTRACT Introduction/Aims Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare disorder of the nervous system that detrimentally influences health‐related quality of life (HRQoL). Evidence regarding factors influencing HRQoL in CIDP is scarce.
Tobias C. Blum   +7 more
wiley   +1 more source

Monoclonal gammopathy of significance [PDF]

open access: yes, 2019
The presence of a monoclonal protein in the serum and/or urine is a common clinical condition that increases in incidence with age. Although the diagnosis is most often monoclonal gammopathy of undetermined significance (MGUS) there are many conditions ...
Dingli, David
core  

What is the significance of monoclonal gammopathy of undetermined significance?

open access: yes, 2018
Monoclonal gammopathy of undetermined significance (MGUS) is characterised by the presence of a monoclonal paraprotein in the blood, without the characteristic end organ damage seen in multiple myeloma.
Catherine Atkin   +5 more
core   +1 more source

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