Results 31 to 40 of about 10,254 (215)

Immunoglobulin M Monoclonal Gammopathies of Clinical Significance

Frontiers in Oncology, 2022
Immunoglobulin M monoclonal gammopathy of undetermined significance (MGUS) comprises 15-20% of all cases of MGUS. IgM MGUS is distinct from other forms of MGUS in that the typical primary progression events include Waldenstrom macroglobulinaemia and ...
Louis-Pierre Girard, Cinnie Yentia Soekojo, Melissa Ooi, Wee Joo Chng, Wee Joo Chng, Wee Joo Chng, Sanjay de Mel   +6 more
doaj   +1 more source

Transcriptome analysis reveals molecular profiles associated with evolving steps of monoclonal gammopathies

Haematologica, 2014
A multistep model has been proposed of disease progression starting in monoclonal gammopathy of undetermined significance continuing through multiple myeloma, sometimes with an intermediate entity called smoldering myeloma, and ending in extramedullary ...
Lucía López-Corral, Luis Antonio Corchete, María Eugenia Sarasquete, María Victoria Mateos, Ramón García-Sanz, Encarna Fermiñán, Juan-José Lahuerta, Joan Bladé, Albert Oriol, Ana Isabel Teruel, María Luz Martino, José Hernández, Jesús María Hernández-Rivas, Francisco Javier Burguillo, Jesús F. San Miguel, Norma C. Gutiérrez   +15 more
doaj   +1 more source

Monoclonal gammopathy of clinical significance (MGCS): when monoclonal gammopathy of undetermined significance (MGUS) is no longer undetermined

, 2021
Monoclonal gammopathy of undetermined significance (MGUS) is a condition characterized by the presence of a monoclonal immunoglobulin (mIg) without its organ- or tissue-damaging effect. In recent years, attention has been paid to patients who show a MGUS-
Usnarska-Zubkiewicz, Lidia; Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland
core   +1 more source

Diagnosis of monoclonal gammopathy of renal significance

, 2015
Monoclonal gammopathy of renal significance (MGRS) regroups all renal disorders caused by a monoclonal immunoglobulin (MIg) secreted by a nonmalignant B-cell clone.
Fernando C. Fervenza, Kyle, R. A., Sanjeev Sethi, Angela Dispenzieri, Guillermo A. Herrera, Dispenzieri, A., Nelson Leung, Jean-Paul Fermand, Samih H. Nasr, Fermand, J. P., Picken, M. M., Murielle Roussel, Hutchison, C. A., International, Kidney, Bridoux, F., Efstathios Kastritis, Leung, N., Touchard, G., Sethi, S., Nasr, S. H., Roussel, M., MERLINI, GIAMPAOLO, Monoclonal Gammopathy Research, Group, Giampaolo Merlini, Herrera, G. A., Robert A. Kyle, Fervenza, F. C., Frank Bridoux, Guy Touchard, Kastritis, E., Colin A. Hutchison, Maria M. Picken   +31 more
core   +2 more sources

CD117 expression in gammopathies is associated with an altered maturation of the myeloid and lymphoid hematopoietic cell compartments and favorable disease features

Haematologica, 2011
Aberrant CD117 expression is associated with a favorable outcome in multiple myeloma. We analyzed 106 patients with symptomatic multiple myeloma (n=50), smoldering multiple myeloma (n=38) and monoclonal gammopathy of undetermined significance (n=18) to ...
Martin Schmidt-Hieber, Martin Pérez-Andrés, Bruno Paiva, Juan Flores-Montero, Jose J. Perez, Norma C. Gutierrez, Maria-Belen Vidriales, Sergio Matarraz, Jesus F. San Miguel, Alberto Orfao   +9 more
doaj   +1 more source

Kidney Transplantation and Monoclonal Gammopathy of Undetermined Significance

Transplantation Direct, 2021
Plasma cell disorders are one of the most common hematologic malignancies. Monoclonal gammopathy of undetermined significance (MGUS) is defined by a serum monoclonal protein
Nabeel Aslam, MD, Christopher L. Trautman, MD, Taimur Sher, MD   +2 more
doaj   +1 more source

Waldenstrom's macroglobulinemia in geriatric practice

Российский журнал гериатрической медицины, 2022
Using the clinical case of Waldenstrom's macroglobulinemia in an older patient, a research was carried out to find an algorithm for diagnosing the disease in patients of advance age, whose frequent polymorbid pathology makes it difficult to diagnose and ...
A. K. Ilyushchenko, L. V. Matchekhina
doaj   +1 more source

Upregulation of Dicer is more frequent in monoclonal gammopathies of undetermined significance than in multiple myeloma patients and is associated with longer survival in symptomatic myeloma patients

Haematologica, 2011
Dicer and Drosha are key enzymes in the miRNA-processing pathway which is altered in many human cancers.We analyzed Dicer and Drosha expression levels by quantitative PCR in 151 patients with monoclonal gammopathies: 102 symptomatic myeloma patients, 23 ...
María E. Sarasquete, Norma C. Gutiérrez, Irena Misiewicz-Krzeminska, Bruno Paiva, María C. Chillón, Miguel Alcoceba, Ramón García-Sanz, Jesús M. Hernández, Marcos González, Jesús F. San-Miguel   +9 more
doaj   +1 more source

The clinical implication of monoclonal gammopathies: monoclonal gammopathy of undetermined significance and of renal significance

Nephrology Dialysis Transplantation, 2018
AbstractMonoclonal gammopathy of renal significance (MGRS) has introduced a new perspective to several well-known disease entities impacting nephrology, haematology and pathology. Given the constantly changing disease spectrum of these entities, it is clinically imperative to establish diagnostic and treatment pathways supported by evidence-based ...
Krzysztof, Batko, Jolanta, Malyszko, Artur, Jurczyszyn, David H, Vesole, Morie A, Gertz, Xavier, Leleu, Anna, Suska, Marcin, Krzanowski, Władysław, Sułowicz, Jacek S, Malyszko, Katarzyna, Krzanowska   +10 more
openaire   +3 more sources

Timing of acquisition of deletion 13 in plasma cell dyscrasias is dependent on genetic context

Haematologica, 2009
Background Multiple myeloma, monoclonal gammopathy of undetermined significance and smoldering multiple myeloma harbor common chromosomal abnormalities but the prevalence and relative association of aberrations in these diagnostic groups remains ...
Laura Chiecchio, Gian Paolo Dagrada, Ashraf H. Ibrahim, Elizabet Dachs Cabanas, Rebecca K.M. Protheroe, David M. Stockley, Kim H. Orchard, Nicholas C.P. Cross, Christine J. Harrison, Fiona M. Ross   +9 more
doaj   +1 more source