Results 51 to 60 of about 23,537 (267)
Advanced Science, EarlyView.RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao +14 more
wiley +1 more source
Advanced Science, EarlyView.An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng +17 more
wiley +1 more source
Advanced Science, EarlyView.Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn +12 more
wiley +1 more source
FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model
Advanced Science, EarlyView.FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble +9 more
wiley +1 more source
Advanced Science, EarlyView.A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li +9 more
wiley +1 more source
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2012 The paper evaluates the onset and duration of spring vegetation phenological stages in a spruce monoculture of the third age class in relation to changing parameters of the environment in the region of the Drahanská vrchovina Upland.
Emilie Bednářová +2 more
doaj +1 more source
Quality Thresholds for Angiogenesis Under Acoustic Manipulation in Engineered Vascular Tissues
Advanced Science, EarlyView.Defined biological and physical quality thresholds achieved through acoustic manipulation regulate cellular alignment and spatial organization, promoting self‐assembling vasculature, extracellular matrix deposition, and angiogenic responses, thereby establishing critical acoustic patterning requirements for engineered vascular tissue development in ...
Oscar O'Dwyer Lancaster‐Jones +5 more
wiley +1 more source
Ribogospodarsʹka Nauka Ukraïni, 2017 Purpose. Examine and analyze the current state of storage fingerlings acipenseriformes cultivation, including sturgeon and paddlefish, in terms of industrial-experimental Dnieper sturgeon fish-growing factory located in the southern Ukraine ...
Ye. Alkhimov, V. Shevchenko
doaj +1 more source
Monoculture Considered Harmful
First Monday, 2002 Monoculture cotton crops and the economy they supported proved susceptible to a small insect in the early twentieth century. There may be parallels in the Internet in the early twenty-first century.
openaire +1 more source
Advanced Science, EarlyView.A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen +15 more
wiley +1 more source