Results 61 to 70 of about 24,873 (267)
Advanced Science, EarlyView.After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi +16 more
wiley +1 more source
Advanced Science, EarlyView.A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian +14 more
wiley +1 more source
Productivity of corn grown in the crop rotation and as monoculture under long-term fertilizing
Зерновое хозяйство России, 2018 Productivity of corn grown in the crop rotation and as monoculture under long-term fertilizing In 1971-2015 on the Voronezh leached black earth there were conducted the researches of the effect of long-term use of various kinds, doses, combinations of ...
A. F. Stulin
doaj
The Potential of Self‐Maintainable Living Materials
Advanced Science, EarlyView.Self‐maintainable living materials are presented as the next generation of bioadaptive systems, integrating continuous sensing, decision‐making, response, self‐repair, and adaptation in a closed‐loop framework. This review highlights the design principles and emerging technologies that enable autonomous, long‐term functionality for future regenerative ...
Mohammadsadegh Nadimifar +4 more
wiley +1 more source
Production of D- and L-Lactic Acid by Mono- and Mixed Cultures of Lactobacillus sp.
Food Technology and Biotechnology, 2011 Batch cultivation of monoculture of Lactobacillus sp. and two–strain mixed culture of Lactobacillus sp. and Lactobacillus amylovorus DSM 20531T was carried out with the aim of producing L-(+)- and D-(–)/L-(+)-lactic acid to be implemented in poly(lactic ...
Antonija Trontel +5 more
doaj
Advanced Science, EarlyView.The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin +13 more
wiley +1 more source
Advanced Science, EarlyView.FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao +11 more
wiley +1 more source
Advanced Science, EarlyView.The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee +5 more
wiley +1 more source
Mineral nitrogen in the soil and its effect on corn yield
Agronomy Science, 2003 Experiments were conducted in a long-term stationary field experiment estab-lished at the experimental field of the Institute of Field and Vegetable Crops in Novi Sad in 1965.
Ljubinko Starčević +2 more
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Frontiers in Physiology, 2018 Herbivores respond differently to the level of plant diversity encountered. Bemisia tabaci Gennadius (Hemiptera: Aleyrodidae) are highly polyphagous herbivores which cause considerable damage to various crops.
Ning Di +5 more
doaj +1 more source