Results 121 to 130 of about 138,183 (374)

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study [PDF]

, 2016
Aging is associated with alterations in the content and patterns of DNA methylation virtually throughout the entire human lifespan. Reasons for these variations are not well understood.
Bacalini, MARIA GIULIA, Bernhardt, Jürgen, Breusing, Nicolle, Bürkle, Alexander, Caiafa, Paola, Calabrese, Roberta, Capri, Miriam, Ciccarone, Fabio, Dollé, Martijn, Franceschi, Claudio, Gonos, Efstathios S, Grubeck Loebenstein, Beatrix, Grune, Tilman, Guastafierro, Tiziana, Hervonen, Antti, Hurme, Mikko, Jansen, Eugène, Koller, Bernhard, Malavolta, Marco, Moreno Villanueva, María, Reale, Anna, Schӧn, Christiane, Sikora, Ewa, Sindlinger, Thilo, Slagboom, P. Eline, Toussaint, Olivier, Zampieri, Michele   +26 more
core   +2 more sources

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

A Sacrificial 3D Printed Vessel‐on‐Chip Demonstrates a Versatile Approach to Model Granulation Tissue

Advanced Healthcare Materials, EarlyView.
A novel method that combines 3D printing and organ‐on‐chip technology enables the creation of hollow channels lined with endothelial cells through a fibroblast‐populated connective tissue matrix. The model supports stable metabolic culture conditions, angiogenic sprouting, and immune cell migration, thereby demonstrating an easy and versatile method to
Jonas Jäger, Phil Berger, Andrew I. Morrison, Hendrik Erfurth, Maria Thon, Eva‐Maria Dehne, Susan Gibbs, Jasper J. Koning   +7 more
wiley   +1 more source

A Human‐Based Skin‐Lymphoreticular Model‐on‐Chip to Emulate Inflammatory Skin Conditions

Advanced Healthcare Materials, EarlyView.
A human‐based lymphoreticular (LR) model was developed through guided self‐assembly and integrated in a skin‐lymphoreticular co‐culture in a microfluidic organ‐on‐chip to mimic interactions between skin and its draining lymph nodes. The human‐based skin‐lymphoreticular model resembles a minimally functional unit that allows to study interactions ...
Zheng Tan, Partho Protim Adhikary, Dana Wörz, Sarah Hedtrich   +3 more
wiley   +1 more source

Increased Monocyte/Lymphocyte Ratio as Risk Marker for Cardiovascular Events and Infectious Disease Hospitalization in Dialysis Patients [PDF]

, 2021
Reiko Muto, Sawako Kato, Bengt Lindholm, Abdul Rashid Qureshi, Takuji Ishimoto, Tomoki Kosugi, Shoichi Maruyama   +6 more
openalex   +1 more source

Increased Anti‐Psoriatic Effect of Anti‐Inflammatory Dendrimers Using Fluid Catanionic Vesicle‐Based Topical Formulations

Advanced Healthcare Materials, EarlyView.
Next‐Generation Psoriasis Therapy – With advanced dendrimer‐based formulations, this study paves the way for highly effective, skin‐permeable treatments. Encapsulated in fluid catanionic vesicles, IMD‐006 and its analogues show promising anti‐psoriatic effects offering a targeted, non‐invasive approach to managing chronic skin inflammation.
Ranime Jebbawi, Abdelouahd Oukhrib, Emily Clement, Hélène Labie, Stéphanie Cassel, Séverine Fruchon, Anne‐Marie Caminade, Michel Simon, Rémy Poupot, Cédric‐Olivier Turrin, Muriel Blanzat   +10 more
wiley   +1 more source

Predicting Survival of Patients with Nonmetastatic Breast Cancer Based on Fibrinogen-to-Albumin Ratio and Lymphocyte-to-Monocyte Ratio: A Nomogram-Based Assessment [PDF]

, 2023
Xiaoyu Chen, Zhi‐Qing Long, Han-Ying Huang, Wen Wen, Fei Lin, Ling Guo, Huan‐Xin Lin   +6 more
openalex   +1 more source

Low pH immobilizes and kills human leukocytes and prevents transmission of cell-associated HIV in a mouse model [PDF]

, 2005
BACKGROUND: Both cell-associated and cell-free HIV virions are present in semen and cervical secretions of HIV-infected individuals. Thus, topical microbicides may need to inactivate both cell-associated and cell-free HIV to prevent sexual transmission ...
A Meehan, A Tachet, AJ Quayle, AR Neurath, AR Neurath, AR Neurath, B Fischer, B Fischer, B Ibata, B Larsen, BM Jones, C Tevi-Benissan, CD Pilcher, CE Hart, CJ Swallow, CJ Swallow, CJ Swallow, D Rodbard, DJ Anderson, DL Sodora, DM Auerbach, E Amaral, ER Boskey, ER Boskey, Erina M Ng, GJ Dougherty, GR Bright, GW Meisenholder, HL Martin, J van De Wijgert, JA Hill, JA Levy, JA Thomas, JEJ Cummins, JR Chaillet, K Mayer, Kristen V Khanna, KV Khanna, KV Khanna, L Tanasugarn, L Zeitlin, M Girard, ME Chamberland, MJ Burkhard, MP Carreno, OJ D'Cruz, Owen N Johnson, PL Vernazza, RC Burghardt, Richard A Cone, Richard B Markham, S Di Fabio, S Di Fabio, S Di Fabio, S Grinstein, S Grinstein, SL Achilles, SS Olmsted, Steven T Whitten, Stuart S Olmsted, TE Taha, Thomas R Moench, TP Huu, TR Moench, VR Zacharopoulos, WH Masters   +65 more
core   +3 more sources

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source