Results 101 to 110 of about 400,128 (308)

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

open access: yesAdvanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu   +6 more
wiley   +1 more source

Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents an advanced in vitro model of the vascular hematopoietic stem cell niche using self‐assembled fibrinogen nanofibers, mimicking the basement membrane in bone marrow (BM) sinusoids. The model supports the coculture of microvascular endothelial cells, stromal cells, and hematopoietic stem and progenitor cells, providing insights into ...
Sophia Lena Meermeyer   +4 more
wiley   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

open access: yesAdvanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin   +18 more
wiley   +1 more source

Fiery Connections: Macrophage-Mediated Inflammation, the Journey from Obesity to Type 2 Diabetes Mellitus and Diabetic Kidney Disease

open access: yesBiomedicines
The high prevalence of diabetes mellitus (DM) poses a significant public health challenge, with diabetic kidney disease (DKD) as one of its most serious consequences.
Satyesh K. Sinha   +2 more
doaj   +1 more source

Granulocyte– and monocyte–platelet adhesion index in coronary and peripheral blood after extracorporeal circulation and reperfusion [PDF]

open access: bronze, 2006
Silverio Sbrana   +7 more
openalex   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

open access: yesAdvanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu   +10 more
wiley   +1 more source

Modelling of macrophage responses to biomaterials in vitro: state-of-the-art and the need for the improvement

open access: yesFrontiers in Immunology
The increasing use of medical implants in various areas of medicine, particularly in orthopedic surgery, oncology, cardiology and dentistry, displayed the limitations in long-term integration of available biomaterials.
Svetlana Piatnitskaia   +9 more
doaj   +1 more source

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