Results 231 to 240 of about 623,154 (347)

Granulocyte-derived extracellular vesicles activate monocytes and are associated with mortality in intensive care unit patients [PDF]

, 2018
Adelman, Avril, et al,, Schechtman, Kenneth B, Spinella, Philip C   +3 more
core   +1 more source

Additional file 15: of Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma

, 2019
Pete A. Williams, Catherine Braine, Krishnakumar Kizhatil, Nicole E. Foxworth, Nicholas Tolman, Jeffrey M. Harder, R. Scott, Gregory L. Sousa, Alyssa Panitch, Gareth R. Howell, Simon W. M. John   +10 more
openalex   +1 more source

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Integrating single-cell RNA-seq and bulk RNA-seq to identify hub pathways and diagnostic biomarkers in active pulmonary tuberculosis. [PDF]

BMC Infect Dis
Wei Y, Sun L, Pan H, Zhong Y, Chen H, Wang J.   +5 more
europepmc   +1 more source

Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis

Advanced Science, EarlyView.
The Irgm1‐PDIA3 axis enhances post‐infarction cardiac repair by accelerating neutrophil clearance and facilitating efferocytosis. Irgm1 holds potential as a prognostic biomarker in MI, and LOC14 may represent a therapeutic option to improve cardiac repair, especially in cases of Irgm1 deficiency.
Zeng Wang, Lai Wei, Mingyang Wang, Shanjie Wang, Lili Xiu, Jiaxiang Sun, Rongzhe Lu, Yige Liu, Jiaxin Wang, Fengyi Liu, Weike Liu, Bo Yu, Yong Sun, Xueqin Gao, Shaohong Fang   +14 more
wiley   +1 more source

Percentage of CD56⁺ monocytes at neutrophil engraftment is associated with the incidence of acute graft-versus-host disease. [PDF]

Ann Hematol
Hashimoto K, Sato T, Ishikawa Y, Okuhiro Y, Sugiyama D, Zhang H, Ito S, Inagaki Y, Miyao K, Sawa M, Morishita T, Goto T, Nishida T, Fukushima N, Ozeki K, Hanajiri R, Terakura S, Nishikawa H, Kiyoi H.   +18 more
europepmc   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Systemic lupus erythematosus extends beyond a type I interferonopathy, as demonstrated by NET-activated monocytes. [PDF]

Clin Transl Med
Cao X, van Heusden N, Pieren DKJ, Geertsema-Hoeve BC, Kaan ED, Greve PF, Limper M, Boes M.   +7 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Monocyte clusters suggestive of a chronic inflammatory phenotype are associated with reduced endothelial function in Veterans with respiratory symptoms. [PDF]

PLoS One
Pappas G, Gardner C, Guo C, Black K, Rancourt R, Laskin D, Kipen H, Sotolongo A, Falvo M, Gow A.   +9 more
europepmc   +1 more source