Results 121 to 130 of about 32,111,831 (291)

The inhibitory effects of 7ND protein on osteoclast differentiation in apical periodontitis

Frontiers in Cellular and Infection Microbiology
BackgroundApical periodontitis (AP) is a highly prevalent inflammatory condition that affects the tissue surrounding the apex of a tooth root. 7ND protein, a mutant form of monocyte chemoattractant protein-1 (MCP-1), functions as a dominant negative ...
Zhang-Zhang Ji, Xiu-Min Xu, Yu-Lin Lu, Run-Zhen Zhang, Ying Zhang, Zhi-Hui Zou, Qi Xu   +6 more
doaj   +1 more source

Serum monocyte chemoattractant protein-1 and monocyte adhesion molecules in type 1 diabetic patients with nephropathy

, 2006
Background. Monocyte chemoattractant protein (MCP)-1 is suggested to be implicated in the pathogenesis of diabetic nephropathy by activating and recruiting monocytes to the glomerulus via regulation of adhesion molecule expressions. The aim of this study

core   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Salivary Monocyte Chemoattractant Protein-1 Levels in Obese Young Adults: A Cross-sectional Study on Early Inflammatory Profiling

Biomedical and Biotechnology Research Journal
Background: Monocyte chemoattractant protein 1 (MCP-1) is a major inflammatory cytokine in obesity that increases the risk of various systemic diseases. This study explored the association between obesity and salivary MCP-1 levels in healthy young adults
N Aravindha Babu, Anusha Mala Nedunchezhian, Elumalai Rajesh, Ramalingam Mathangi   +3 more
doaj   +1 more source

Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia

, 2006
To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae.
de Vos, Alex F., Dessing, Mark C., van der Poll, Tom, Florquin, Sandrine   +3 more
core   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, EarlyView.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

Regulated expression of monocyte chemoattractant protein-1 in normal human osteoblastic cells

, 1992
An influx of monocytes is observed in many different physiological and pathophysiological states, including bone remodeling and injury. These cells appear at early stages of bone formation and repair and persist throughout the later stages.
G. Dorsam, S. R. Williams, Y. Jiang, D. T. Graves, D. Cochran   +4 more
core   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Monocyte chemoattractant protein-1 [PDF]

Journal of Hypertension, 2004
openaire   +1 more source

Role of defensins in immunothrombosis

Rheumatology &Autoimmunity, EarlyView.
Defensins are important proteins that link the immune system and blood clotting, playing a key role in immunothrombosis. α‐defensins mainly come from neutrophils, while β‐defensins are produced by epithelial cells and platelets. These proteins help form blood clots in several ways: they slow down clot breakdown (fibrinolysis), activate platelets, and ...
Yuebing Wang, Guijuan Guo, Xiangjun Liu, Xiaoyu Chen, Wenqiong Wang, Patapong Towiwat, Ru Li, Chun Li   +7 more
wiley   +1 more source