Results 141 to 150 of about 130,905 (336)

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Monocyte chemoattractant protein-1 and nitric oxide promote adipogenesis in a model that mimics obesity

, 2007
Objective: An increasing body of evidence is emerging linking adipogenesis and inflammation. Obesity, alone or as a part of the metabolic syndrome, is characterized by a state of chronic low-level inflammation as revealed by raised plasma levels of ...
Thompson, Erik W., Thomas, Gregory P. L., Wayne A. Morrison, Keren M. Abberton, Penington, Anthony J., Karsten Hemmrich, Thomas, Gregory P.L., Rophael, John A., John A. Rophael, Anthony J. Penington, Hemmrich, Karsten, Erik W. Thompson, Abberton, Keren M., Morrison, Wayne A., Gregory P.L. Thomas   +14 more
core   +1 more source

The inhibitory effects of 7ND protein on osteoclast differentiation in apical periodontitis

Frontiers in Cellular and Infection Microbiology
BackgroundApical periodontitis (AP) is a highly prevalent inflammatory condition that affects the tissue surrounding the apex of a tooth root. 7ND protein, a mutant form of monocyte chemoattractant protein-1 (MCP-1), functions as a dominant negative ...
Zhang-Zhang Ji, Xiu-Min Xu, Yu-Lin Lu, Run-Zhen Zhang, Ying Zhang, Zhi-Hui Zou, Qi Xu   +6 more
doaj   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Suppressive Role of Endogenous Endothelial Monocyte Chemoattractant Protein–1 on Monocyte Transendothelial Migration In Vitro

, 1995
Monocyte chemoattractant protein–1 (MCP-1, or monocyte chemotactic and activating factor) is thought to play an important role in monocyte infiltration into tissue, but little is known about its effect on monocyte-endothelium interaction. We examined the
Masafumi Takahashi, Uichi Ikeda, Kazuyuki Shimada, Shogo Kano, Jun-Ichi Masuyama, Tadashi Kasahara, Sei-Ichi Kitagawa, Masaki Saito   +7 more
core   +1 more source

Preclinical Evaluation of Berry Extracts as a Nutritional Intervention to Alleviate Myocardial Ischemia–Reperfusion Injury and Atherosclerosis Development

Phytotherapy Research, EarlyView.
Schematic representation of the experimental design and the proposed mechanisms underlying the cardioprotective and anti‐atherosclerotic effects of Greek‐derived berry extracts. C57BL/6 mice with WD–induced MS and ApoE−/− mice with atherosclerosis received chronic supplementation with WMex or BBex.
Lydia Symeonidi, Panagiota‐Efstathia Nikolaou, Panagiotis Stathopoulos, Andriana Christodoulou, Alexandra Svouraki, Panagiotis Efentakis, Christina Chania, Angeliki Choustoulaki, Maria Xenaki, Anna Agapaki, Maria Tsoumani, Nikolaos Kostomitsopoulos, Ioulia Tseti, Gemma Vilahur, Alexios‐Leandros Skaltsounis, Ioanna Andreadou   +15 more
wiley   +1 more source

Salivary Monocyte Chemoattractant Protein-1 Levels in Obese Young Adults: A Cross-sectional Study on Early Inflammatory Profiling

Biomedical and Biotechnology Research Journal
Background: Monocyte chemoattractant protein 1 (MCP-1) is a major inflammatory cytokine in obesity that increases the risk of various systemic diseases. This study explored the association between obesity and salivary MCP-1 levels in healthy young adults
N Aravindha Babu, Anusha Mala Nedunchezhian, Elumalai Rajesh, Ramalingam Mathangi   +3 more
doaj   +1 more source

Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice.

Molecules and Cells, 1998
L. Gu, Y. Okada, S. Clinton, C. Gerard, G. Sukhova, P. Libby, B. Rollins   +6 more
semanticscholar   +1 more source

Resveratrol downregulates TNF-α-induced monocyte chemoattractant protein-1 in primary rat pulmonary artery endothelial cells by P38 mitogen-activated protein kinase signaling

, 2019
Jian-Wei Lin,1 Le-He Yang,2 Zhuo-Chao Ren,3 De-Guang Mu,3 Ya-Qing Li,3 Jian-Ping Yan,3 Liang-Xing Wang,4 Chun Chen31Department of Cardiology, Xiasha Campus, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310018, Zhejiang ...
Ren ZC, Li YQ, Yang LH, Lin JW, Yan JP, Wang LX, Mu DG, Chen C   +7 more
core  

Platelet activating factor and monocyte chemoattractant protein-1 in children with refractory epilepsy

, 2014
Background: Epilepsy is an important common and diverse group of symptom complexes characterized by recurrent spontaneous seizures. It is estimated that about 5-10% of all cases of epilepsy eventually become refractory.
Alm El-Din, Rasha A, Abd El-Aziz, Sahar A   +1 more
core   +1 more source