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Hyperfunctional G proteins in mononuclear leukocytes of patients with mania
Biological Psychiatry, 1991In a recent study, we found that lithium inhibits the function of guanine nucleotide-binding proteins, implicating G proteins as the common site for both the antimanic and antidepressant therapeutic effects of lithium. These findings may also suggest that an altered G protein function is of pathophysiological importance in bipolar affective disorder ...
G, Schreiber +3 more
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The production of growth hormone by subpopulations of rat mononuclear leukocytes
Cellular Immunology, 1991In this study we analyzed the production of GH mRNA and secretion of GH by purified subpopulations of rat lymphoid cells. The data demonstrate that mononuclear leukocytes from various tissues, including spleen, thymus, bone marrow, Peyer's patches, and peripheral blood, all have the ability to produce GH mRNA and secrete GH.
D A, Weigent, J E, Blalock
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Depressed Mononuclear Leukocyte Chemotaxis in Thermally Injured Patients
The Journal of Immunology, 1977Abstract Microbial infection is the leading cause of morbidity and mortality in thermally injured patients. Since normal mononuclear leukocytes (MNL) function is essential in host defense, the chemotactic response of MNL from 25 thermally injured patients was evaluated in vitro.
L C, Altman +2 more
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Corticosteroid receptors and lymphocyte subsets in mononuclear leukocytes in aging
American Journal of Physiology-Endocrinology and Metabolism, 1992Plasma cortisol and aldosterone levels and number of related receptors in mononuclear leukocytes were measured in 49 healthy aged subjects (62-97 yr) and in 21 adult controls (21-50 yr). In all subjects, in addition, lymphocyte subsets were determined as an index of corticosteroid action.
ARMANINI, DECIO +5 more
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Effect of dialysable leukocyte extract on the mononuclear leukocytes in Hodgkin's disease.
Haematologia, 1985Therapy with dialysable leukocyte extract repeated 6 times, had a beneficial effect on the impaired functions of mononuclear leukocytes in Hodgkin's disease. The decreased phagocytosis and chemotaxis of monocytes increased almost to the values of healthy controls.
K, Lukács +5 more
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Interaction of mononuclear leukocytes with malignant melanoma.
Laboratory investigation; a journal of technical methods and pathology, 1981Since it is well established that cellular immunity plays a role in the defense against melanoma, the morphologic aspects of this reaction warranted investigation. Accordingly, peripheral blood mononuclear cells obtained from healthy donors were incubated with human melanoma cells for 1 to 24 hours to examine, on the ultrastructural level, the cellular
N, Fujinami +2 more
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Zinc concentrations in mononuclear and polymorphonuclear leukocytes
Clinica Chimica Acta, 1986S K, Purcell, K M, Hambidge, M A, Jacobs
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Glucocorticoid Receptors of Human Mononuclear Leukocytesin Vitro*
The Journal of Clinical Endocrinology & Metabolism, 1983The present study was performed to analyze glucocorticoid receptor binding in peripheral blood mononuclear leukocytes from normal adult humans. In addition, the potential regulatory effect of excess amounts of glucocorticoids and thyroid hormones on glucocorticoid receptor binding was investigated.
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Separation of mononuclear leukocytes and polymorphonuclear leukocytes from equine blood.
Canadian journal of comparative medicine : Revue canadienne de medecine comparee, 1977The present study describes a two step technique for the separation of mononuclear leukocytes or mononuclear and polymorphonuclear leukocytes from whole equine blood. First, the leukocyte rich plasma was obtained by sedimentation of erythrocytes in the undiluted blood.
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