Results 61 to 70 of about 9,732 (256)

Targeting glutamate metabolism in melanoma [PDF]

arXiv, 2019
The glutamate metabotropic receptor 1 (GRM1) drives oncogenesis when aberrantly activated in melanoma and several other cancers. Metabolomics reveals that patient-derived xenografts with GRM1-positive melanoma tumors exhibit elevated plasma glutamate levels associated with metastatic melanoma in vivo. Stable isotope tracing and GCMS analysis determined
arxiv  

Chemical Toxicants Used for Food Preservation in Africa. Is it a Case of Ignorance or Food Fraud? A Review

Health Science Reports, Volume 8, Issue 4, April 2025.
ABSTRACT Background and Aims This review examined the use of chemical preservatives in food preservation and the food fraud risks associated with its misuse in Africa. In Africa, there is growing reliance on the use of synthetic chemical preservation such as benzoates, nitrates or sorbates to preserve foods to improve the storage life of the foods ...
Nnabueze Darlington Nnaji, Helen Onyeaka, Kingsley Tochukwu Ughamba, Chukwuebuka Maxwell Ononugbo, Chinasa Valerie Olovo, Ifeanyi Michael Mazi   +5 more
wiley   +1 more source

A computational study on synaptic and extrasynaptic effects of astrocyte glutamate uptake on orientation tuning in V1 [PDF]

arXiv, 2017
Astrocytes affect neural transmission by a tight control via glutamate transporters on glutamate concentrations in direct vicinity to the synaptic cleft and by extracellular glutamate. Their relevance for information representation has been supported by in-vivo studies in ferret and mouse primary visual cortex.
arxiv  

A Review of the Alleged Health Hazards of Monosodium Glutamate [PDF]

Comprehensive Reviews in Food Science and Food Safety, 2019
AbstractMonosodium glutamate (MSG) is an umami substance widely used as flavor enhancer. Although it is generally recognized as being safe by food safety regulatory agencies, several studies have questioned its long‐term safety. The purpose of this review was to survey the available literature on preclinical studies and clinical trials regarding the ...
Anca Zanfirescu, Anca Ungurianu, Aristides M. Tsatsakis, George M. Nițulescu, Demetrios Kouretas, Aris Veskoukis, Dimitrios Tsoukalas, Ayse B. Engin, Michael Aschner, Denisa Margină   +9 more
openaire   +4 more sources

European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management

United European Gastroenterology Journal, Volume 13, Issue 3, Page 427-471, April 2025.
ABSTRACT Introduction Chronic nausea and vomiting are symptoms of a wide range of gastrointestinal and non‐gastrointestinal conditions. Diagnosis can be challenging and requires a systematic and well‐structured approach. If the initial investigation for structural, toxic and metabolic disorders is negative, digestive motility and gut‐brain interaction ...
Carolina Malagelada, Jutta Keller, Daniel Sifrim, Jordi Serra, Jan Tack, Agata Mulak, Andreas Stengel, Ariadna Aguilar, Asbjorn Mohr Drewes, Axel Josefsson, Bruno Bonaz, Dan Dumitrascu, Daniel Keszthelyi, Elizabeth Barba, Florencia Carbone, Frank Zerbib, Giovanni Marchegiani, Goran Hauser, Guillaume Gourcerol, Hans Tornblom, Heinz Hammer, Imran Aziz, Jelena Rakic Matic, Juan Mendive, Kornilia Nikaki, Lucas Wauters, Luis Gerardo Alcalá‐González, Marek Waluga, Mariana Jinga, Maura Corsetti, Nathalie Rommel, Ray Shidrawi, Roberto De Giorgio, Sritharan Kadirkamanathan, Teodora Surdea‐Blaga   +34 more
wiley   +1 more source

The Effect of MSG (Monosodium Glutamate) Addition on The Quality of Yoghurt Frozen Culture Starter Viewed Viability, pH Value and Acidity

Jurnal Ilmu dan Teknologi Hasil Ternak, 2012
The objective of this study was to investigate wether the effect of percentage monosodium glutamat addition on the quality of yoghurt frozen culture starter viewed viability, pH value and acidity.The experimental design used in this study was Randomised ...
Aris Sri Widati, Abdul Manab, Teguh Hadi Waluyo   +2 more
doaj  

Epidemiological Studies of Monosodium Glutamate and Health [PDF]

Journal of Nutrition & Food Sciences, 2013
Epidemiology studies regarding to monosodium glutamate and health are limited, since three studies surveyed by questionnaires the relation between monosodium glutamate and Chinese restaurant syndrome; five studies analyzed the association of monosodium glutamate and overweight or obesity; one study related the monosodium glutamate and hypertension; one
Tamami Iwamoto, Shigeru Yamamoto, Saiko Shikanai, Hien VuThiThu, Noriko Wakikawa, Andrea Wakita   +5 more
openaire   +2 more sources

Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential

Advanced Science, Volume 12, Issue 10, March 13, 2025.
The fungal BET protein Bdf1 is a potential antifungal target in pathogenic Candida species requiring the inhibition of both its bromodomains. Humanized Candida strains and NanoBiT complementation assays developed to evaluate on‐target antifungal efficacy expedite the discovery of Bdf1 bromodomain inhibitors with antifungal potential, supporting BET ...
Kaiyao Wei, Marie Arlotto, Justin M. Overhulse, Tuan‐Anh Dinh, Yingsheng Zhou, Nathan J. Dupper, Jiayi Yang, Boris A. Kashemirov, Hasan Dawi, Cécile Garnaud, Gaëlle Bourgine, Flore Mietton, Morgane Champleboux, Amédé Larabi, Yordan Hayat, Rose‐Laure Indorato, Marjolaine Noirclerc‐Savoye, Dimitrios Skoufias, Muriel Cornet, Gwenaël Rabut, Charles E. McKenna, Carlo Petosa, Jérôme Govin   +22 more
wiley   +1 more source

Acetylcholinesterase, Specific Acetylcholinesterase and Total Protein Concentrations in the Brain Regions of Broiler Chickens Fed Dietary Monosodium Glutamate

Turkish Journal of Agriculture: Food Science and Technology, 2019
The study was carried out to examine the effect of varied levels of dietary monosodium glutamate on acetylcholinesterase, specific acetylcholinesterase and total protein concentrations in the brain regions of broiler chickens.
Olumuyiwa Joseph Olarotimi, Imoleayo Sarah Oladeji, Olufemi Adesanya Adu, Francis Ayodeji Gbore   +3 more
doaj   +1 more source

Multiple Routes for Glutamate Receptor Trafficking: Surface Diffusion and Membrane Traffic Cooperate to Bring Receptors to Synapses [PDF]

Science's STKE (electronic resource) : signal transduction knowledge environment 327 (21/03/2006) 13, 2007
Trafficking of glutamate receptors into and out of synapses is critically involved in the plasticity of excitatory synaptic transmission. Endocytosis and exocytosis of receptors have initially been thought to account alone for this trafficking. However, membrane proteins also traffic through surface lateral diffusion in the plasma membrane. We describe
arxiv