Results 51 to 60 of about 7,817,516 (255)

Building capacity for integrated health care—nursing education initiatives in a Canadian mental health setting

BMJ Open Quality
Background Individuals with serious mental illness at a Toronto mental health hospital receive interdisciplinary team (IDT) care through a reverse integration model supporting both mental and physical health. Nurses play a central role in this model, yet
Elnathan Mesfin, Cristina de Lasa, Eleanor Lam, Sherida Chambers   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

A prospective real-world analysis of erenumab in refractory chronic migraine

The Journal of Headache and Pain, 2020
Background Clinical trials have shown the safety and clinical superiority of erenumab compared to placebo in chronic migraine (CM). The aim of this analysis is to evaluate the effectiveness and tolerability of erenumab in a real-world setting in patients
Giorgio Lambru, Bethany Hill, Madeleine Murphy, Ivona Tylova, Anna P. Andreou   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

On relation between the power mean and the logarithmic mean

, 2010
碩士假設x及y是不同的正數，則 M = Mp (x , y) 稱冪平均數， L = L (x , y) 稱對數平均數。 Lin.[3]已證明 : 若Mp < L 則p 0 , 以及若L < Mq , 則q 。 我們將證明在某些限制下的x和y，當q 0 ，L > Mp。If x , y are distinct positive numbers, then M = Mp (x , y) is called the ...
張碧菁; Chang, Bi-ching
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Assessment of Ambient Air Pollution in Istanbul during 2003-2013

Iranian Journal of Public Health, 2018
Background: We investigated the air quality changes from 2003-2013 in Istanbul, Turkey. Methods: We studied SO2, CO and PM concentration patterns in 10 districts of Istanbul.
Eray YURTSEVEN, Suphi VEHİD, Merve BOSAT, Selçuk KÖKSAL, Cemile Nihal YURTSEVEN   +4 more
doaj  

Impact of provincial and national implementation strategies on P2Y12 inhibitor utilization for acute coronary syndrome in the elderly: an interrupted time series analysis from 2008 to 2018

Implementation Science, 2021
Background Guidelines recommend both acetylsalicylic acid and ticagrelor following acute coronary syndrome (ACS), but appropriate prescription practices lag.
Saurabh Gupta, Emilie P. Belley-Cote, Adam Eqbal, Charlotte McEwen, Ameen Basha, Nicole Wu, Joshua O. Cerasuolo, Shamir Mehta, Jon-David Schwalm, Richard P. Whitlock   +9 more
doaj   +1 more source

MA23 - Mean monthly flows

, 2018
IHA metric describing mean monthly flow in m3 s-1.
Katie Irving (4517752)
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source