Results 61 to 70 of about 1,482,643 (350)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress. [PDF]
, 2018 BACKGROUND:Chronic life stress, such as the stress of caregiving, can promote pathophysiology, but the underlying cellular mechanisms are not well understood.
Aschbacher, Kirstin +7 more
core +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Journal of Eating DisordersBackground Higher level of care (HLOC) treatment for eating disorders (EDs) is sometimes necessary, but research is lacking on whether HLOCs are actually more effective than less structured, lower levels of care.
Renee D. Rienecke +7 more
doaj +1 more source
More than Money: Social Class, Income, and the Intergenerational Persistence of Advantage
Sociological Science, 2017 I provide a uniquely comprehensive empirical integration of the sociological and economic approaches to the intergenerational transmission of advantage.
Carina Mood
doaj +1 more source
Coping Strategies and Perceived Support in Adolescents and Young Adults: Predictive Model of Self-Reported Cognitive and Mood Problems [PDF]
, 2016 The aims of this study were: to assess cognitive and mood problems, perceived social support and coping strategies in adolescence and early adulthood; to understand how coping strategies are related to age, gender and years of schooling; to identify ...
Bonichini, Sabrina +2 more
core +1 more source
FEBS Open Bio, EarlyView.This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc +8 more
wiley +1 more source
Hypohydration and Mood State in Free-Living Males and Females [PDF]
, 2015 Previous research has shown that acute dehydration can result in changes in mood. These changes have been reported in less than a 1% loss in total body water. However, the effect of hypohydration (i.e., reflected through high urine concentration) on mood
Vidal, Thomas Edward
core +2 more sources
Perceived Community Cohesion and the Stress Process in Youth [PDF]
, 2011 Using survey data from two youth samples, one rural and one urban, we examine the role and significance of perceived community cohesion in the stress process. In particular, we assess the extent to which community attachment and detachment are related to
Cohn, Ellen S +4 more
core +2 more sources