Results 41 to 50 of about 580,174 (313)

Relationships of affective temperament ratings to diagnosis and morbidity measures in major affective disorders

European Psychiatry, 2021
Background Ratings of affective temperament types show promise in helping to differentiate diagnostic groups among major affective disorders as well as to predict associations with important aspects of morbidity including suicidal risk.
Alessandro Miola, Ross J. Baldessarini, Marco Pinna, Leonardo Tondo   +3 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Biochemical and Endocrine Parameters for the Discrimination and Calibration of Bipolar Disorder or Major Depressive Disorder

Frontiers in Psychiatry, 2022
ObjectivesConventional biochemical indexes may have predictive values in clinical identification between bipolar disorder (BD) and major depressive disorder (MDD).MethodsThis study included 2,470 (BD/MDD = 1,333/1,137) hospitalized patients in Shanghai ...
Yuncheng Zhu, Yuncheng Zhu, Haifeng Ji, Zhiang Niu, Hongmei Liu, Xiaohui Wu, Lu Yang, Zuowei Wang, Jun Chen, Yiru Fang, Yiru Fang, Yiru Fang   +11 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Establishment and validation a relapse prediction model for bipolar disorder

Frontiers in Psychiatry
BackgroundThe recurrence rate of bipolar disorder (BD) is relatively high. Assessing the risk of relapse in patients with BD can assist in identifying populations at high risk for recurrence, and early feasible interventions can improve patient ...
Xiaoqian Zhang, Xiaoqian Zhang, Xiaoqian Zhang, Xiaoqian Zhang, Minghao Wu, Daojin Wang, Long Wang, Long Wang, Long Wang, Wen Xie, Wen Xie, Wen Xie   +11 more
doaj   +1 more source

Association between cognitive function and performance on effort based decision making in patients with major depressive disorder treated with Vortioxetine

Comprehensive Psychiatry, 2019
Background: It is well established that deficits in motivation, reward, and cognition are common during and in between syndromal episodes of depression as part of Major Depressive Disorder (MDD).
Mehala Subramaniapillai, Rodrigo B. Mansur, Hannah Zuckerman, Caroline Park, Yena Lee, Michelle Iacobucci, Bing Cao, Roger Ho, Kangguang Lin, Lee Phan, Roger S. McIntyre   +10 more
doaj   +1 more source

The THINC-it Tool for Cognitive Assessment and Measurement in Major Depressive Disorder: Sensitivity to Change

Frontiers in Psychiatry, 2020
BackgroundHerein, we sought to determine the sensitivity to change in cognitive function, as measured by the THINC-it tool, in a sample of adults with major depressive disorder (MDD) receiving standardized antidepressant therapy.MethodsAdults meeting the
Roger S. McIntyre, Roger S. McIntyre, Roger S. McIntyre, Roger S. McIntyre, Roger S. McIntyre, Mehala Subramaniapillai, Caroline Park, Caroline Park, Hannah Zuckerman, Bing Cao, Yena Lee, Yena Lee, Michelle Iacobucci, Flora Nasri, Dominika Fus, Christopher R. Bowie, Christopher R. Bowie, Tanya Tran, Joshua D. Rosenblat, Rodrigo B. Mansur, Rodrigo B. Mansur   +20 more
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Probing the clinical and brain structural boundaries of bipolar and major depressive disorder

Translational Psychiatry, 2021
Bipolar disorder (BD) and major depressive disorder (MDD) have both common and distinct clinical features, that pose both conceptual challenges in terms of their diagnostic boundaries and practical difficulties in optimizing treatment.
Tao Yang, Sophia Frangou, Raymond W. Lam, Jia Huang, Yousong Su, Guoqing Zhao, Ruizhi Mao, Na Zhu, Rubai Zhou, Xiao Lin, Weiping Xia, Xing Wang, Yun Wang, Daihui Peng, Zuowei Wang, Lakshmi N. Yatham, Jun Chen, Yiru Fang   +17 more
doaj   +1 more source