Results 71 to 80 of about 1,249,932 (293)

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Ethical Analyses of Smart City Applications

Urban Science, 2018
When it comes to smart cities, one of the most important components is data. To enable smart city applications, data needs to be collected, stored, and processed to accomplish intelligent tasks.
Sawyer Clever, Tyler Crago, Alex Polka, Jameela Al-Jaroodi, Nader Mohamed   +4 more
doaj   +1 more source

Effect of Re-impacting Debris on the Solidification of the Lunar Magma Ocean

, 2018
Anorthosites that comprise the bulk of the lunar crust are believed to have formed during solidification of a Lunar Magma Ocean (LMO) in which these rocks would have floated to the surface.
Abe, Alibert, Andrews-Hanna, Asphaug, Bandermann, Barnes, Barr, Borg, Borg, Borg, Bottinga, Boyce, Boyce, Boyet, Breuer, Cameron, Canup, Canup, Chambers, Chen, Cox, Cuk, Cuk, Daly, Dohnanyi, Elkins-Tanton, Elkins-Tanton, Elkins-Tanton, Eppelbaum, Gaffney, Gast, Hartmann, Ida, Jackson, Jackson, Kato, Kaula, Kirk, Kokubo, Kokubo, Konrad, Leinhardt, Lin, Lin, Longhi, Longhi, Luhmann, Marcus, Mastrobuono-Battisti, Matson, Matsuyama, McCubbin, McLeod, Melosh, Merk, Meyer, Minear, Monteux, Nemchin, Neumann, Niemela, Nyquist, Nyquist, O'Hara, O'Neill, Ogawa, Pahlevan, Pepin, Philpotts, Piskorz, Pritchard, Rankenburg, Ransford, Rathbun, Repetto, Reufer, Riner, Rolf, Rufu, Ryder, Saal, Salmon, Senshu, Sharp, Shirley, Snyder, Solomon, Solomon, Solomon, Spera, Spicuzza, Squyres, Takeda, Tanaka, Taylor, Taylor, Taylor, Taylor, Tian, Touboul, Touboul, Touma, Touma, Turcotte, Vander Kaaden, Wakita, Walker, Walker, Warner, Warren, Warren, Wieczorek, Williams, Wolf, Wood, Wood, Wyatt, Yamamoto, Yamamoto, Zhang, Zhang   +120 more
core   +1 more source

Metabologenomic Hallmark‐Based Discovery of Bacterial Thioamides as a New Lead against Drug‐Resistant Pancreatic Cancer

Advanced Science, EarlyView.
A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du, Eun Seo Bae, Thinh T. M. Bui, Seok Beom Lee, Dahan Kim, Jin‐Gyeong Park, Yongjoo Park, Soo Yeon Park, Sangwook Kang, Beomsu Lee, Daniel Shin, Yun Pyo Kang, In‐Gyun Lee, Dae‐Duk Kim, Seokhee Kim, Suckchang Hong, Kyuho Moon, Sang Kook Lee, Dong‐Chan Oh   +18 more
wiley   +1 more source

Navigating the Fault Lines in Civic Food Networks

Journal of Agriculture, Food Systems, and Community Development, 2016
Civic food networks have emerged as a civil society–driven response to the social, economic, and environmental shortcomings of the industrial food system.
Colin Ray Anderson, Wayne McDonald, Jo-Lene Gardiner, Stéphane M. McLachlan   +3 more
doaj   +1 more source

SIRT1 Prevents Ferroptosis in Corneal Epithelial Cells by Enhancing HIF1α Protein Stability in Dry Eye Disease

Advanced Science, EarlyView.
Hyperosmotic stress drives ferroptosis in corneal epithelium via SIRT1 downregulation. This work demonstrates that SIRT1 activation stabilizes HIF1α, which transcriptionally upregulates GPX4 to inhibit lipid peroxidation and cell death. The identified SIRT1/HIF1α/GPX4 axis reveals a novel defense mechanism and potential therapy for dry eye disease ...
Lili Lian, Zhenmin Le, Xuanqiao Ye, Zimo Wang, Jiuxiao Li, Chenyu Dong, Yetao Shen, Jiazheng Li, Yueping Ren, Xiaoyin Ma, Wei Chen, Qinxiang Zheng   +11 more
wiley   +1 more source

Biocontrol Activity of Myxococcus sp. KYC 1126 against Phytophthora Blight on Hot Pepper

Research in Plant Disease, 2011
Bacteriolytic myxobacteria have been known to secrete various antifungal metabolites against several soilborne phytopathogens including Phytophthora.
Sung Chul Yun , Sung Taek Kim
doaj   +1 more source

The Astrobiology of Alien Worlds: Known and Unknown Forms of Life

Universe, 2020
Most definitions of life assume that, at a minimum, life is a physical form of matter distinct from its environment at a lower state of entropy than its surroundings, using energy from the environment for internal maintenance and activity, and capable of
Louis N. Irwin, Dirk Schulze-Makuch
doaj   +1 more source

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source

GTransCYPs: an improved graph transformer neural network with attention pooling for reliably predicting CYP450 inhibitors

Journal of Cheminformatics
State‑of‑the‑art medical studies proved that predicting CYP450 enzyme inhibitors is beneficial in the early stage of drug discovery. However, accurate machine learning-based (ML) in silico methods for predicting CYP450 inhibitors remains challenging ...
Candra Zonyfar, Soualihou Ngnamsie Njimbouom, Sophia Mosalla, Jeong-Dong Kim   +3 more
doaj   +1 more source