Results 121 to 130 of about 5,705 (144)
Bidirectional crosstalk between the catalytic and moonlighting functions of human dipeptidyl peptidase 3: potential physiological implications. [PDF]
RSC AdvMatić A +9 more
europepmc +1 more source
Trends in Biochemical Sciences, 1999 The idea of one gene--one protein--one function has become too simple because increasing numbers of proteins are found to have two or more different functions. The multiple functions of such moonlighting proteins add another dimension to cellular complexity and benefit cells in several ways.
Constance J Jeffery
exaly +4 more sources
Moonlighting Proteins: An Intriguing Mode of Multitasking
Biochimica Et Biophysica Acta - Molecular Cell Research, 2010 Proteins are macromolecules, which perform a large variety of functions. Most of them have only a single function, but an increasing number of proteins are being identified as multifunctional. Moonlighting proteins form a special class of multifunctional proteins. They perform multiple autonomous and often unrelated functions without partitioning these
Ida Johanna van der Klei +1 more
exaly +4 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Annual Review of Genetics, 2020
The single gene, single protein, single function hypothesis is increasingly becoming obsolete. Numerous studies have demonstrated that individual proteins can moonlight, meaning they can have multiple functions based on their cellular or developmental context. In this review, we discuss moonlighting proteins, highlighting the biological pathways where
Needhi Bhalla
exaly +3 more sources
The single gene, single protein, single function hypothesis is increasingly becoming obsolete. Numerous studies have demonstrated that individual proteins can moonlight, meaning they can have multiple functions based on their cellular or developmental context. In this review, we discuss moonlighting proteins, highlighting the biological pathways where
Needhi Bhalla
exaly +3 more sources
Mitochondrial Proteins Moonlighting in the Nucleus
Trends in Biochemical Sciences, 2015Mitochondria function as cellular energy generators, producing the fuel required to drive biological processes. The response of cells to mitochondrial activity or dysfunction regulates their survival, growth, proliferation, and differentiation. Several proteins that contain mitochondrial-targeting sequences (MTS) also reside in the nucleus and there is
Monaghan, Richard, Whitmarsh, Alan
openaire +3 more sources
Ceruloplasmin, a moonlighting protein in fish
Fish & Shellfish Immunology, 2018Ceruloplasmin is an ancient multicopper oxidase evolved to insure a safe handling of oxygen in some metabolic pathways of vertebrates. The current knowledge of its structure provides a glimpse of its plasticity, revealing a multitude of binding sites that point to an elaborate mechanism of multifunctional activity.
Sweta, Das, Pramoda Kumar, Sahoo
openaire +2 more sources
An introduction to protein moonlighting
Biochemical Society Transactions, 2014Moonlighting proteins comprise a class of multifunctional proteins in which a single polypeptide chain performs multiple physiologically relevant biochemical or biophysical functions. Almost 300 proteins have been found to moonlight. The known examples of moonlighting proteins include diverse types of proteins, including receptors, enzymes ...
openaire +2 more sources
Virulence of Acinetobacter baumannii in proteins moonlighting
Archives of Microbiology, 2021The diverse function of the moonlighting proteins in Acinetobacter baumannii is highly associated with its virulence that had spurred renewed attention in recent years. The existing and newly formed hypothetical moonlighting proteins, evolve without jeopardizing the structural constraints of their original roles.
A. S. Smiline Girija +1 more
openaire +2 more sources
Moonlighting proteins—an update
Molecular BioSystems, 1900Abstract A growing number of diverse proteins are being identified that moonlight. Moonlighting proteins comprise an interesting subset of multifunctional proteins in which the two functions are found in a single polypeptide chain.
openaire +2 more sources
Moonlighting proteins in sperm–egg interactions
Biochemical Society Transactions, 2014Sperm–egg interaction is a highly species-specific step during the fertilization process. The first steps consist of recognition between proteins on the sperm head and zona pellucida (ZP) glycoproteins, the acellular coat that protects the oocyte. We aimed to determine which sperm head proteins interact with ZP2, ZP3 and ZP4 in humans.
François M, Petit +2 more
openaire +2 more sources