Results 81 to 90 of about 5,705 (144)

Metabolic Structure: A Paradigm Revisited in Light of the Fundamental Parameters of Living Systems

BioEssays, Volume 48, Issue 10, October 2026.
Metabolism is redefined as a dynamic thermodynamic field shaped by six fundamental parameters (time, water, entropy, quantum effects, space, and electrostatics) rather than fixed genetic architecture. Case studies from enzyme kinetics to cancer cell differentiation show metabolic states, not structure alone, determine flux and control, and can be ...
Jacques Fantini
wiley   +1 more source

Telomeres: Moonlighting by DNA repair proteins [PDF]

Current Biology, 1998
Chromosome ends, or telomeres, are dynamic DNA structures maintained by a multisubunit telomerase and other proteins. New evidence indicates that proteins previously implicated in the repair of DNA doublestrand breaks also play an important role in the control of telomere organization and length.
openaire   +2 more sources

Targeting Moonlighting Enzymes in Cancer

Molecules
Moonlighting enzymes are multifunctional proteins that perform multiple functions beyond their primary role as catalytic enzymes. Extensive research and clinical practice have demonstrated their pivotal roles in the development and progression of cancer,
Chunxu Lin, Mingyang Yu, Ximei Wu, Hui Wang, Min Wei, Luyong Zhang   +5 more
doaj   +1 more source

Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes

Bioscience Reports, 2013
The concept of one-protein–multiple-function, i.e. moonlighting proteins, is an ever-expanding paradigm. We obtained compelling evidence that an array of ‘cytoplasmic’ metabolic enzymes can enter the nuclei to carry out moonlighting ...
Hongpeng He, Mei‑Chin Lee, Li‑Ling Zheng, Lei Zheng, Yan Luo   +4 more
doaj   +1 more source

NLRC4 Acts as a Non‐Canonical Tumour Suppressor in Lung Adenocarcinoma by Inhibiting PI3K/AKT/mTOR Signalling to Induce Protective Autophagy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.
ABSTRACT Autophagy plays complex, context‐dependent roles in lung adenocarcinoma (LUAD), but the upstream molecular drivers that govern this process remain elusive. NLRC4 is classically defined as a pyroptosis‐inducing inflammasome sensor, yet its non‐canonical, tumour‐intrinsic function in LUAD progression remains largely unexplored.
Yuxin Zhang, Shuangteng Liu, Rui Li, Mengyu Zhang, Guang Yang, Xinmiao Zhu, Yiqing Qu   +6 more
wiley   +1 more source

Synaptic Proteostasis in Health and Disease

Journal of Neurochemistry, Volume 170, Issue 10, October 2026.
The localised creation and degradation of proteins at the pre and postsynaptic terminal are processes that are crucial for neuronal homeostasis. Synaptic proteostasis pathways are frequently reported as dysregulated in neurodevelopmental and neurodegenerative disorders.
Paul G. Donlin‐Asp, Emma L. Clayton
wiley   +1 more source

Prediction of Disordered Regions and Their Roles in the Anti-Pathogenic and Immunomodulatory Functions of Butyrophilins

Molecules, 2018
Butyrophilins (BTNs) are a group of the moonlighting proteins, some members of which are secreted in milk. They constitute a large family of structurally similar type 1 transmembrane proteins from the immunoglobulin superfamily.
Elrashdy M. Redwan, Ahmed M. Al-Hejin, Hussein A. Almehdar, Abdelrahman M. Elsaway, Vladimir N. Uversky   +4 more
doaj   +1 more source

CDO1 as a prognostic biomarker and therapeutic target in gastric cancer: Mechanistic insights into the PI3K/AKT‐THBS1 axis and epigenetic reactivation by decitabine

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CDO1 is a tumour suppressor in gastric cancer that directly binds PI3K p85α, disrupting p85α–p110α dimerization to inhibit the PI3K/AKT–THBS1 axis. Decitabine epigenetically restores CDO1 expression and exerts CDO1‐dependent anti‐tumour activity, synergizing with 5‐FU. Abstract Background As a pivotal metabolic enzyme, cysteine dioxygenase type 1 (CDO1)
Fazhi Wang, Runkai Zhou, Jinfeng Cai, Jiazhe Wen, Abudushalamu Yalikun, Yang Yu, Yugang Wen   +6 more
wiley   +1 more source

The multifunctional or moonlighting protein CD26/DPPIV

European Journal of Cell Biology, 2003
CD26/DPPIV can be considered a moonlighting protein because it is a multifunctional protein that exerts its different functions depending on cell type and intra- or extracellular conditions in which it is expressed. In the present review, we summarize all its known functions in relation to physiological and pathophysiological conditions. The protein is
Emil, Boonacker, Cornelis J F, Van Noorden   +1 more
openaire   +2 more sources

Clathrin mediated endocytosis - Methods and Protocols

European Journal of Histochemistry, 2019
Clathrin is one of the interesting “moonlighting proteins” which perform multiple functions relevant to biochemical or biophysical aspects. It can be considered the master regulator of vesicular trafficking being the main player of the Clathrin-Mediated ...
Manuela Monti
doaj   +1 more source