Results 101 to 110 of about 93,615 (260)

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Ezh2 Inhibits the Differentiation of Short‐Lived Effector CD8+ T Cells and Promotes T Cell‐Dependent Antitumor Immunity

Cancer Science, EarlyView.
The antitumor immune response is attenuated in T cell‐specific Ezh2 knockout mice. ABSTRACT Appropriate regulation of the differentiation balance between effector CD8+ T cells and memory CD8+ T cells is crucial for an appropriate immune response. We previously reported that the tumor suppressor menin suppresses the differentiation of CD8+ T cells into ...
Kenji Takagi, Junpei Suzuki, Yuko Matsuoka, Makoto Kuwahara, Taro Oshikiri, Masakatsu Yamashita   +5 more
wiley   +1 more source

Intersections of Class and Colonisation: Access to Dental Care for Indigenous Peoples in Canada

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives Inequitable access to healthcare is a central driver of the disproportionate burden of disease in Indigenous peoples. The aim of this study is to investigate inequities in access to dental care, accounting for supra‐additive effects at the intersections of educational attainment, household income, and Indigeneity.
Nasir Z. Bashir, Gustavo G. Nascimento
wiley   +1 more source

Oral self-assembly nanoemulsion drives <i>in vivo</i> hepatic stellate cell-targeting drug delivery in liver fibrosis. [PDF]

Drug Deliv
Shen X, Deng J, Jiang A, Cai Q, Tian D, Zhao L, Ye J, Zhang L, Xiang Y, Zhang Q.   +9 more
europepmc   +1 more source

Public Dental Expenditure and Dental Visits in Europe and Japan

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Background Dental care is important for oral health, but access to dental services is subject to social inequalities and varies between countries. Despite this, few cross‐national studies have examined how public dental expenditure relates to dental service use among older adults. This study aimed to investigate the associations between public
Yuko Inoue, Jun Aida, Richard G. Watt, Anja Heilmann   +3 more
wiley   +1 more source

Long-Term Outcomes After Multiorgan Resection of Primary Gastrointestinal Stromal Tumors. [PDF]

Ann Surg Open
Musa J, Willis F, Kochendoerfer SM, Sauerteig C, Rompen IF, Grünewald TGP, Harnoss JC, Al-Saeedi M, Büchler MW, Schneider M.   +9 more
europepmc   +1 more source

Client‐Perpetrated Violence and Intent to Leave Among Child Welfare Workers: A Three‐Wave Cross‐Lagged Prospective Study of Causal Directions and the Role of Work‐Related Worrying

Child &Family Social Work, EarlyView.
ABSTRACT Client‐perpetrated violence and turnover intentions are widespread problems among child‐welfare workers and are associated with both personal and organizational consequences. To elucidate their longitudinal association, the current study built on the cognitive activation theory of stress (CATS) and investigated (H1) whether client‐perpetrated ...
Sana Parveen, Live Bakke Finne, Silje Endresen Reme, Morten Birkeland Nielsen   +3 more
wiley   +1 more source

G-protein regulatory network governs receptor internalization dynamics. [PDF]

Proc Natl Acad Sci U S A
Rowe JB, Pandey S, Mayer RA, Ludlam WG, Drube J, Inoue A, Hoffmann C, Martemyanov KA.   +7 more
europepmc   +1 more source

The Impact of Early Childhood Caries on Asthma Trajectories During the First 15 Years of Life

Allergy, EarlyView.
Claireta Handoko, Ankur Singh, Shyamali C. Dharmage, Yanhong J. Hu, Stuart G. Dashper, Randi J. Bertelsen, Adrian J. Lowe, Diego J. Lopez   +7 more
wiley   +1 more source