Results 111 to 120 of about 1,054,609 (336)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur   +6 more
wiley   +1 more source

Truncated Octahedral PtCu Alloy Nanoparticles for Efficient Methanol Electrooxidation

open access: yesMetalMat, EarlyView.
Platinum–copper nano‐truncated octahedra are developed as efficient electrocatalysts for methanol oxidation in alkaline media, exhibiting notably enhanced activity compared to commercial Pt/C. Experimental and theoretical analysis reveals that alloying with copper modifies the electronic structure of platinum, facilitating the key reaction step and ...
Mengfei Liu   +5 more
wiley   +1 more source

Leveraging Public Transit for Robotic Deliveries: A Column Generation Approach

open access: yesNaval Research Logistics (NRL), EarlyView.
ABSTRACT Autonomous mobile robots (AMRs) are small, electric, wheeled vehicles that operate at pedestrian speeds. In the last‐mile delivery service considered in this study, a fleet of AMRs is deployed across multiple recharging depots within a service area, from which they depart to perform point‐to‐point deliveries. We consider an operational setting
Yishay Shapira, Mor Kaspi
wiley   +1 more source

High Temperature Corrosion of Inconel 600 in NaCl-KCl Molten Salts

open access: yesAdvances in Materials Science and Engineering, 2014
In this work the corrosion resistance of a high content nickel alloy, Inconel 600, was investigated in mixed NaCl-KCl salts at 700, 800, and 900°C for 100 hours in static air.
G. Salinas-Solano   +5 more
doaj   +1 more source

Lectotypifications and taxonomic changes in the holoparasitic Orobanchaceae

open access: yesNordic Journal of Botany, EarlyView.
Based on further extensive studies of specimens in various herbaria, lectotypes are designated for many taxa of holoparasitic Orobanchaceae. In particular, 47 names in the genera Boschniakia (incl. Xylanche), Cistanche, Orobanche, Phelipanche and Phelypaea are lectotypified.
Holger Uhlich   +5 more
wiley   +1 more source

Integrating SOMs and a Bayesian Classifier for Segmenting Diseased Plants in Uncontrolled Environments

open access: yesThe Scientific World Journal, 2014
This work presents a methodology that integrates a nonsupervised learning approach (self-organizing map (SOM)) and a supervised one (a Bayesian classifier) for segmenting diseased plants that grow in uncontrolled environments such as greenhouses, wherein
Deny Lizbeth Hernández-Rabadán   +2 more
doaj   +1 more source

CUL3‐Related Neurodevelopmental Disorder: Expanding the Prenatal Phenotype

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Objective Pathogenic variants of the CUL3 gene are known to cause a neurodevelopmental disorder with a partially described prenatal phenotype. This study further characterizes and expands the spectrum of prenatal sonographic findings associated with the disorder to improve prenatal diagnosis and counseling.
Yoel Gofin   +12 more
wiley   +1 more source

Range‐wide sampling reveals cryptic lineages but largely conserved mycorrhizal associations in the Japanese fairy lantern Thismia kobensis

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
The jewel‐like flowers of Thismia are as rare as they are beautiful, often recorded from only a single site per species. Access to 15 populations of T. kobensis has enabled an uncommon, range‐wide assessment of morphology, genetics, and fungal partners. Our analyses showed that T.
Kenji Suetsugu   +4 more
wiley   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai   +6 more
wiley   +1 more source

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