Results 131 to 140 of about 93,615 (260)

Analyzing the Chemical Space of Opioid Receptor Agonists and Antagonists: Insights from Computational Models. [PDF]

ACS Omega
Yu T, Anuwongcharoen N, Wang ZJ, Piacham T.   +3 more
europepmc   +1 more source

Characterization of the Pharmacokinetics and Physiological Effects of Tapentadol in Horses

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Tapentadol is a dual mechanism analgesic utilizing both μ‐opioid receptor (MOR) agonism and norepinephrine reuptake inhibition (NRI). This study evaluated the pharmacokinetics and pharmacodynamics of tapentadol as a potential analgesic with the goal of treating pain in horses.
Annabella D. Lynch, Khursheed R. Mama, Dan S. McKemie, Phillip H. Kass, Heather K. Knych   +4 more
wiley   +1 more source

Multifocal Optical-Resolution Photoacoustic Microscopy With a Masked Single-Element Transducer. [PDF]

IEEE Trans Med Imaging
Luo X, Cao R, Hu P, Luo Y, Zeng Y, Zhang Y, Cui M, Zhou Q, Ku G, Wang LV.   +9 more
europepmc   +1 more source

Word Predictability as a Measure of Second Language Proficiency

Language Learning, EarlyView.
Abstract This study introduces predictabilityBERT, a novel metric for assessing second language (L2) proficiency based on the predictability of word choices in learner language production. Using BERT (Devlin et al., 2019), we calculated the conditional probability of each word in a text given its surrounding context.
Langdon Holmes, Scott Crossley, Wesley Morris, Joon Suh Choi   +3 more
wiley   +1 more source

Structural Modification and Development of <i>N</i>-(1,2,3,4-Tetrahydro-3-isoquinolinylmethyl)benzamide, BPR1M492, as a Potent and Rapid-Onset Opioid Analgesic with Reduced Withdrawal Symptoms. [PDF]

J Med Chem
Chang PW, Chang YC, Tien YW, Chang HF, Chen SR, Chen YP, Huang WC, Hsieh CC, Chang L, Zhuang H, Yeh TK, Tung CW, Yeh SH, Ueng SH.   +13 more
europepmc   +1 more source

A Nutrient‐Responsive LuxR Regulator Orchestrates Effector Gene Expression Across the Legionella Genus

Molecular Microbiology, EarlyView.
LexR1 is a LuxR‐type regulator that links nutrient sensing to effector gene expression in Legionella. Activated by a casamino acid‐derived ligand, LexR1 directly controls multiple effector genes using a conserved regulatory element present in numerous putative effectors across different Legionella species.
Chen Adler, Gil Segal
wiley   +1 more source

Efficacy and safety of radiotherapy combined with chemoimmunotherapy versus chemoimmunotherapy alone as first-line treatment for metachronous oligorecurrent esophageal squamous cell carcinoma. [PDF]

Front Oncol
Lv X, Wang Y, Ai J, Chen S, Tan Y, Li X, Yan X, Wang J.   +7 more
europepmc   +1 more source

Mapping of a New Locus for Powdery Mildew Resistance in the Caucasus Apple Malus orientalis

Plant Breeding, EarlyView.
ABSTRACT Powdery mildew is one of the most significant fungal diseases affecting apple, both the tree and its fruits, causing considerable economic losses to apple growers. Controlling this disease can require the application of multiple fungicides. A more sustainable approach is to grow resistant cultivars.
Buist Muçaj, Janne Lempe, Henryk Flachowsky, Andreas Peil   +3 more
wiley   +1 more source

The Tsetlin Machine: A "Third Way" in QSAR Modeling. [PDF]

J Chem Inf Model
Clarke PFA, Cmelo I, Helin R, Shende MK, Granmo OC, Fayne D.   +5 more
europepmc   +1 more source

Transcript correlation analysis for the identification of novel plant genes involved in iron metabolism and beyond: what next?

Plant Biology, EarlyView.
Transcript correlation analysis allowed the identification of several key nodes in the complex regulatory network of plant iron metabolism. Abstract Arabidopsis thaliana was the first plant genome to be fully sequenced, almost a quarter of a century ago, thanks to The Arabidopsis Genome Initiative, with contributions from scientists worldwide.
I. Murgia, P. Morandini
wiley   +1 more source